Distinct class of DNA-binding domains is exemplified by a master regulator of phenotypic switching in Candida albicans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 32, 2010, Pages 14105-14110

  Lohse, Matthew B ^a   Zordan, Rebecca E ^a,b   Cain, Christopher W ^a   Johnson, Alexander D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA motif; DNA protein interaction; Gene expression; Heritable states of transcription; Transcription factor

Indexed keywords

DNA BINDING PROTEIN; FUNGAL DNA; FUNGAL PROTEIN; PROTEIN WOR1; UNCLASSIFIED DRUG; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CANDIDA ALBICANS; DNA BINDING; DNA SEQUENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; NUCLEOTIDE SEQUENCE;

CANDIDA ALBICANS; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; PHENOTYPE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

CANDIDA ALBICANS;

EID: 77956271587     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1005911107     Document Type: Article

References (34)

1. MacPherson S, Larochelle M, Turcotte B (2006) A fungal family of transcriptional regulators: The zinc cluster proteins. Microbiol Mol Biol R 70:583-604. (Pubitemid 44484686)
2. Wilson D, Charoensawan V, Kummerfeld SK, Teichmann SA (2008) DBD - taxonomically broad transcription factor predictions: New content and functionality. Nucleic Acids Res 36:D88-D92. (Pubitemid 351149701)
3. Shelest E (2008) Transcription factors in fungi. FEMS Microbiol Lett 286:145-151.
4. Lohse MB, Johnson AD (2009) White-opaque switching in Candida albicans. Curr Opin Microbiol 12:650-654.
5. Huang G, et al. (2006) Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci USA 103:12813-12818.
6. Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD (2007) Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans. PLoS Biol 5:e256.
7. Srikantha T, et al. (2006) TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell 5:1674-1687.
8. Miller MG, Johnson AD (2002) White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110:293-302.
9. Kvaal CA, Srikantha T, Soll DR (1997) Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicansaffects switching and virulence. Infect Immun 65:4468-4475. (Pubitemid 27463213)
10. Kvaal C, et al. (1999) Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicansconfers increased virulence in a mouse model of cutaneous infection. Infect Immun 67:6652-6662.
11. Geiger J, Wessels D, Lockhart SR, Soll DR (2004) Release of a potent polymorphonuclear leukocyte chemoattractant is regulated by white-opaque switching in Candida albicans. Infect Immun 72:667-677.
12. Lohse MB, Johnson AD (2008) Differential phagocytosis of white versus opaque Candida albicansby Drosophilaand mouse phagocytes. PLoS One 3:e1473.
13. Lan CY, et al. (2002) Metabolic specialization associated with phenotypic switching in Candida albicans. Proc Natl Acad Sci USA 99:14907-14912.
14. Altschul SF, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
15. Altschul SF, et al. (2005) Protein database searches using compositionally adjusted substitution matrices. FEBS J 272:5101-5109.
16. Kelley LA, Sternberge MJE (2009) Protein structure prediction on the web: A case study using the Phyre server. Nat Protoc 4:363-371.
17. Nguyen VQ, Sil A (2008) Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatumrequires Ryp1, a conserved transcriptional regulator. Proc Natl Acad Sci USA 105:4880-4885.
18. Caspari T (1997) Onset of gluconate-H+ symport in Schizosaccharomyces pombeis regulated by the kinases Wis1 and Pka1, and requires the gti1 + gene product. J Cell Sci 110:2599-2608.
19. Michielse CM, et al. (2009) The nuclear protein Sge1 of Fusarium oxysporumis required for parasitic growth. PLoS Pathog 5:e1000637.
20. Kunitomo H, Sugimoto A, Wilkinson CR, Yamamoto M (1995) Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade. Curr Genet 28:32-38.
21. Webster RH, Sil A (2008) Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum. Proc Natl Acad Sci USA 105:14573-14578.
22. Santos MA, Tuite MF (1995) The CUG codon is decoded in vivoas serine and not leucine in Candida albicans. Nucleic Acids Res 29:1481-1486.
23. Reece RJ, Ptashne M (1993) Determinants of binding-site specificity among yeast C6 zinc cluster proteins. Science 261:909-911.
24. Bailey TL, Elkan C (1994) Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology (AAAI Press, Menlo Park, CA), pp 28-36.
25. Hope IA, Struhl K (1987) GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J 6:2781-2784.
26. Puntervoll P, et al. (2003) ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res 31:3625-3630.
27. Linding R, Russell RB, Neduva V, Gibson TJ (2003) GlobPlot: Exploring protein sequences for globularity and disorder. Nucleic Acids Res 31:3701-3708. (Pubitemid 37442227)
28. Homann OR, Johnson AD (2010) MochiView: versatile software for genome browsing and DNA motif analysis. BMC Biol 8:49.
29. Rupp S, Summers E, Lo H, Madhani H, Fink G (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18:1257-1269.
30. Guarente L, Ptashne M (1981) Fusion of Escherichia coli lacZto the cytochrome cgene of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 78:2199-2203. (Pubitemid 11119888)
31. Mumberg D, Müller R, Funk M (1995) Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156:119-122.
32. Johnston M, Riles L, Hegemann JH (2002) Gene disruption. Method Enzymol 350:290-315.
33. Chodosh L (1988) Mobility shift DNA-binding assay using gel electrophoresis. Current Protocols in Molecular Biology, (Wiley, Hoboken, NJ), Vol 2, pp 12.12.11-12.12.10.
34. Rupp S (2002) LacZ assays in yeast. Method Enzymol 350:112-131.