Outer membrane vesicles of Vibrio vulnificus deliver cytolysin-hemolysin VvhA into epithelial cells to induce cytotoxicity

Biochemical and Biophysical Research Communications

Volumn 399, Issue 4, 2010, Pages 607-612

  Kim, Young Ran ^a,c   Kim, Bang Ul ^a   Kim, Soo Young ^a   Kim, Choon Mee ^a,d   Na, Hee Sam ^a   Koh, Jeong Tae ^b   Choy, Hyon E ^a   Rhee, Joon Haeng ^a   Lee, Shee Eun ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

^c Dongshin University   (South Korea)

^d Chosun University College of Medicine   (South Korea)

Author keywords

Apoptosis; Cytolysin hemolysin (VvhA); Leukocidin domain; Outer membrane vesicle; Vibrio vulnificus

Indexed keywords

CHOLESTEROL; CYTOLYSIN; HEMOLYSIN; LEUKOCIDIN; BACTERIAL PROTEIN; CYTOTOXIN; VIRULENCE FACTOR; VVHA PROTEIN, VIBRIO VULNIFICUS;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL DEATH; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; HOST CELL; HUMAN; HUMAN CELL; MEMBRANE VESICLE; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; VIBRIO VULNIFICUS; ANIMAL; APOPTOSIS; CELL MEMBRANE; HELA CELL LINE; METABOLISM; MOUSE; PATHOGENICITY; PROTEIN TRANSPORT; TRANSPORT VESICLE;

ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; CELL MEMBRANE; CHOLESTEROL; CYTOTOXINS; EPITHELIAL CELLS; HELA CELLS; HUMANS; MICE; PROTEIN TRANSPORT; TRANSPORT VESICLES; VIBRIO VULNIFICUS; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); MUS; NEGIBACTERIA; OAT MOSAIC VIRUS; VIBRIO VULNIFICUS;

EID: 77956267156     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.122     Document Type: Article

References (37)

1. Jones M.K., Oliver J.D. Vibrio vulnificus: disease and pathogenesis. Infect. Immun. 2009, 77:1723-1733.
2. Strom M.S., Paranjpye R.N. Epidemiology and pathogenesis of Vibrio vulnificus. Microbes Infect. 2000, 2:177-188.
3. Tacket C.O., Brenner F., Blake P.A. Clinical features and an epidemiological study of Vibrio vulnificus infections. J. Infect. Dis. 1984, 149:558-561.
4. Kim Y.R., Lee S.E., Kook H., Yeom J.A., Na H.S., Kim S.Y., Chung S.S., Choy H.E., Rhee J.H. Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells. Cell. Microbiol. 2008, 10:848-862.
5. Gray L.D., Kreger A.S. Purification and characterization of an extracellular cytolysin produced by Vibrio vulnificus. Infect. Immun. 1985, 48:62-72.
6. Lee S.E., Ryu P.Y., Kim S.Y., Kim Y.R., Koh J.T., Kim O.J., Chung S.S., Choy H.E., Rhee J.H. Production of Vibrio vulnificus hemolysin in vivo and its pathogenic significance. Biochem. Biophys. Res. Commun. 2004, 324:86-91.
7. Kim H.R., Rho H.W., Jeong M.H., Park J.W., Kim J.S., Park B.H., Kim U.H., Park S.D. Hemolytic mechanism of cytolysin produced from V. vulnificus. Life Sci. 1993, 53:571-577.
8. Kwon K.B., Yang J.Y., Ryu D.G., Rho H.W., Kim J.S., Park J.W., Kim H.R., Park B.H. Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells. J. Biol. Chem. 2001, 276:47518-47523.
9. Park J.W., Ma S.N., Song E.S., Song C.H., Chae M.R., Park B.H., Rho R.W., Park S.D., Kim H.R. Pulmonary damage by Vibrio vulnificus cytolysin. Infect. Immun. 1996, 64:2873-2876.
10. Gray L.D., Kreger A.S. Mouse skin damage caused by cytolysin from Vibrio vulnificus and by V. vulnificus infection. J. Infect. Dis. 1987, 155:236-241.
11. Kook H., Lee S.E., Baik Y.H., Chung S.S., Rhee J.H. Vibrio vulnificus hemolysin dilates rat thoracic aorta by activating guanylate cyclase. Life Sci. 1996, 59:PL41-PL47.
12. Kook H., Rhee J.H., Lee S.E., Kang S.Y., Chung S.S., Cho K.W., Baik Y.H. Activation of particulate guanylyl cyclase by Vibrio vulnificus hemolysin. Eur. J. Pharmacol. 1999, 365:267-272.
13. Wright A.C., Morris J.G. The extracellular cytolysin of Vibrio vulnificus: inactivation and relationship to virulence in mice. Infect. Immun. 1991, 59:192-197.
14. Fan J.J., Shao C.P., Ho Y.C., Yu C.K., Hor L.I. Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin. Infect. Immun. 2001, 69:5943-5948.
15. Ritchie J.M., Waldor M.K. Vibrio cholerae interactions with the gastrointestinal tract: lessons from animal studies. Curr. Top. Microbiol. Immunol. 2009, 337:37-59.
16. Kim Y.R., Lee S.E., Kim C.M., Kim S.Y., Shin E.K., Shin D.H., Chung S.S., Choy H.E., Progulske-Fox A., Hillman J.D., Handfield M., Rhee J.H. Characterization and pathogenic significance of Vibrio vulnificus antigens preferentially expressed in septicemic patients. Infect. Immun. 2003, 71:5461-5471.
17. Conner C.P., Heithoff D.M., Mahan M.J. In vivo gene expression: contributions to infection, virulence, and pathogenesis. Curr. Top. Microbiol. Immunol. 1998, 225:1-12.
18. Christie P.J., Atmakuri K., Krishnamoorthy V., Jakubowski S., Cascales E. Biogenesis, architecture, and function of bacterial type IV secretion systems. Annu. Rev. Microbiol. 2005, 59:451-485.
19. Cianciotto N.P. Type II secretion: a protein secretion system for all seasons. Trends Microbiol. 2005, 13:581-588.
20. Galan J.E., Collmer A. Type III secretion machines: bacterial devices for protein delivery into host cells. Science 1999, 284:1322-1328.
21. Henderson I.R., Navarro-Garcia F., Desvaux M., Fernandez R.C., Ala'Aldeen D. Type V protein secretion pathway: the autotransporter story. Microbiol. Mol. Biol. Rev. 2004, 68:692-744.
22. Kuehn M.J., Kesty N.C. Bacterial outer membrane vesicles and the host-pathogen interaction. Genes Dev. 2005, 19:2645-2655.
23. Ellis T.N., Kuehn M.J. Virulence and immunomodulatory roles of bacterial outer membrane vesicles. Microbiol. Mol. Biol. Rev. 2010, 74:81-94.
24. Wai S.N., Lindmark B., Soderblom T., Takade A., Westermark M., Oscarsson J., Jass J., Richter-Dahlfors A., Mizunoe Y., Uhlin B.E. Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin. Cell 2003, 115:25-35.
25. Kato S., Kowashi Y., Demuth D.R. Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. Microb. Pathog. 2002, 32:1-13.
26. Kesty N.C., Mason K.M., Reedy M., Miller S.E., Kuehn M.J. Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. EMBO J. 2004, 23:4538-4549.
27. Furuta N., Takeuchi H., Amano A. Entry of Porphyromonas gingivalis outer membrane vesicles into epithelial cells causes cellular functional impairment. Infect. Immun. 2009, 77:4761-4770.
28. Lindmark B., Rompikuntal P.K., Vaitkevicius K., Song T., Mizunoe Y., Uhlin B.E., Guerry P., Wai S.N. Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni. BMC Microbiol. 2009, 9:220.
29. Schild S., Nelson E.J., Bishop A.L., Camilli A. Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera. Infect. Immun. 2009, 77:472-484.
30. Schild S., Nelson E.J., Camilli A. Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice. Infect. Immun. 2008, 76:4554-4563.
31. Sambrook J., Russell D.W. Molecular Cloning a Laboratory Manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. third ed.
32. Shinoda S., Miyoshi S., Yamanaka H., Miyoshi-Nakahara N. Some properties of Vibrio vulnificus hemolysin. Microbiol. Immunol. 1985, 29:583-590.
33. Lee S.E., Kim S.Y., Jeong B.C., Kim Y.R., Bae S.J., Ahn O.S., Lee J.J., Song H.C., Kim J.M., Choy H.E., Chung S.S., Kweon M.N., Rhee J.H. A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity. Infect. Immun. 2006, 74:694-702.
34. Kim B.S., Kim J.S. Cholesterol induce oligomerization of Vibrio vulnificus cytolysin specifically. Exp. Mol. Med. 2002, 34:239-242.
35. Yu H.N., Lee Y.R., Park K.H., Rah S.Y., Noh E.M., Song E.K., Han M.K., Kim B.S., Lee S.H., Kim J.S. Membrane cholesterol is required for activity of Vibrio vulnificus cytolysin. Arch. Microbiol. 2007, 187:467-473.
36. Heczko U., Smith V.C., Mark Meloche R., Buchan A.M., Finlay B.B. Characteristics of Helicobacter pylori attachment to human primary antral epithelial cells. Microbes Infect. 2000, 2:1669-1676.
37. Tan T.T., Morgelin M., Forsgren A., Riesbeck K. Haemophilus influenzae survival during complement-mediated attacks is promoted by Moraxella catarrhalis outer membrane vesicles. J. Infect. Dis. 2007, 195:1661-1670.