메뉴 건너뛰기




Volumn 12, Issue 5, 2010, Pages 335-348

Molecular testing in lung cancer: The time is now

Author keywords

Biomarkers; EGFR; EML4 ALK translocation; KRAS; Molecular testing; Non small cell lung cancer

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; ANAPLASTIC LYMPHOMA KINASE; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; BIOLOGICAL MARKER; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; GEFITINIB; GEMCITABINE; K RAS PROTEIN; MESENCHYMAL EPITHELIAL TRANSITION FACTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MET; N [4 (3 CHLORO 4 FLUOROANILINO) 7 (TETRAHYDRO 3 FURYLOXY) 6 QUINAZOLINYL] 4 DIMETHYLAMINO 2 BUTENAMIDE; NAVELBINE; PEMETREXED; PLACEBO; PROTEIN EML4; PROTEIN P53; RIBONUCLEOTIDE REDUCTASE SUBUNIT M1; SCATTER FACTOR RECEPTOR; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 184; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; TUMOR MARKER;

EID: 77956266461     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-010-0118-z     Document Type: Review
Times cited : (19)

References (86)
  • 1
    • 0346238665 scopus 로고    scopus 로고
    • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
    • 10.1056/NEJMoa031644 14736927
    • R Arriagada B Bergman A Dunant, et al. 2004 Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer N Engl J Med 350 351 360 10.1056/NEJMoa031644 14736927
    • (2004) N Engl J Med , vol.350 , pp. 351-360
    • Arriagada, R.1    Bergman, B.2    Dunant, A.3
  • 2
    • 20544455590 scopus 로고    scopus 로고
    • Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
    • 10.1056/NEJMoa043623 1:CAS:528:DC%2BD2MXls1Wqurg%3D 15972865
    • T Winton R Livingston D Johnson, et al. 2005 Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer N Engl J Med 352 2589 2597 10.1056/NEJMoa043623 1:CAS:528:DC%2BD2MXls1Wqurg%3D 15972865
    • (2005) N Engl J Med , vol.352 , pp. 2589-2597
    • Winton, T.1    Livingston, R.2    Johnson, D.3
  • 3
    • 0025074419 scopus 로고
    • K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
    • 1:STN:280:DyaK3czktVemsQ%3D%3D 2199829
    • RJ Slebos RE Kibbelaar O Dalesio, et al. 1990 K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung N Engl J Med 323 561 565 1:STN:280:DyaK3czktVemsQ%3D%3D 2199829
    • (1990) N Engl J Med , vol.323 , pp. 561-565
    • Slebos, R.J.1    Kibbelaar, R.E.2    Dalesio, O.3
  • 4
    • 19944430434 scopus 로고    scopus 로고
    • The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis
    • 10.1038/sj.bjc.6602258 1:CAS:528:DC%2BD2MXhtFSjsrs%3D 15597105
    • C Mascaux N Iannino B Martin, et al. 2005 The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis Br J Cancer 92 131 139 10.1038/sj.bjc.6602258 1:CAS:528:DC%2BD2MXhtFSjsrs%3D 15597105
    • (2005) Br J Cancer , vol.92 , pp. 131-139
    • Mascaux, C.1    Iannino, N.2    Martin, B.3
  • 5
    • 73949154000 scopus 로고    scopus 로고
    • Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: Updated survival analysis of JBR-10
    • 10.1200/JCO.2009.24.0333 1:CAS:528:DC%2BC3cXhtF2ku7s%3D 19933915
    • CA Butts K Ding L Seymour, et al. 2010 Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10 J Clin Oncol 28 29 34 10.1200/JCO.2009.24.0333 1:CAS:528:DC%2BC3cXhtF2ku7s%3D 19933915
    • (2010) J Clin Oncol , vol.28 , pp. 29-34
    • Butts, C.A.1    Ding, K.2    Seymour, L.3
  • 6
    • 0027473475 scopus 로고
    • Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer
    • 1:CAS:528:DyaK3sXnvValtg%3D%3D 8380124
    • Y Horio T Takahashi T Kuroishi, et al. 1993 Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer Cancer Res 53 1 4 1:CAS:528:DyaK3sXnvValtg%3D%3D 8380124
    • (1993) Cancer Res , vol.53 , pp. 1-4
    • Horio, Y.1    Takahashi, T.2    Kuroishi, T.3
  • 7
    • 0033854786 scopus 로고    scopus 로고
    • Reduced expression levels of nucleotide excision repair genes in lung cancer: A case-control analysis
    • 10.1093/carcin/21.8.1527 1:CAS:528:DC%2BD3cXlvVeqsbY%3D 10910954
    • L Cheng MR Spitz WK Hong Q Wei 2000 Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis Carcinogenesis 21 1527 1530 10.1093/carcin/21.8.1527 1:CAS:528: DC%2BD3cXlvVeqsbY%3D 10910954
    • (2000) Carcinogenesis , vol.21 , pp. 1527-1530
    • Cheng, L.1    Spitz, M.R.2    Hong, W.K.3    Wei, Q.4
  • 8
    • 15844372318 scopus 로고    scopus 로고
    • ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer
    • 10.1378/chest.127.3.978 15764785
    • GR Simon S Sharma A Cantor, et al. 2005 ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer Chest 127 978 983 10.1378/chest.127.3.978 15764785
    • (2005) Chest , vol.127 , pp. 978-983
    • Simon, G.R.1    Sharma, S.2    Cantor, A.3
  • 9
    • 33748435058 scopus 로고    scopus 로고
    • DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    • 10.1056/NEJMoa060570 1:CAS:528:DC%2BD28XpsFKmtLw%3D 16957145
    • KA Olaussen A Dunant P Fouret, et al. 2006 DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy N Engl J Med 355 983 991 10.1056/NEJMoa060570 1:CAS:528:DC%2BD28XpsFKmtLw%3D 16957145
    • (2006) N Engl J Med , vol.355 , pp. 983-991
    • Olaussen, K.A.1    Dunant, A.2    Fouret, P.3
  • 10
    • 33847107236 scopus 로고    scopus 로고
    • DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer
    • 10.1056/NEJMoa065411 1:CAS:528:DC%2BD2sXhvFKltLs%3D 17314339
    • Z Zheng T Chen X Li, et al. 2007 DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer N Engl J Med 356 800 808 10.1056/NEJMoa065411 1:CAS:528:DC%2BD2sXhvFKltLs%3D 17314339
    • (2007) N Engl J Med , vol.356 , pp. 800-808
    • Zheng, Z.1    Chen, T.2    Li, X.3
  • 11
    • 3042701602 scopus 로고    scopus 로고
    • RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer
    • 10.1200/JCO.2004.12.002 1:CAS:528:DC%2BD2cXptlCksr0%3D 15143080
    • G Bepler S Sharma A Cantor, et al. 2004 RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer J Clin Oncol 22 1878 1885 10.1200/JCO.2004.12.002 1:CAS:528:DC%2BD2cXptlCksr0%3D 15143080
    • (2004) J Clin Oncol , vol.22 , pp. 1878-1885
    • Bepler, G.1    Sharma, S.2    Cantor, A.3
  • 12
    • 65349114099 scopus 로고    scopus 로고
    • Genomics of lung cancer
    • 10.1513/pats.200807-076LC 1:CAS:528:DC%2BD1MXltlOqt7s%3D 19349483
    • AC Borczuk RL Toonkel CA Powell 2009 Genomics of lung cancer Proc Am Thorac Soc 6 152 158 10.1513/pats.200807-076LC 1:CAS:528:DC%2BD1MXltlOqt7s%3D 19349483
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 152-158
    • Borczuk, A.C.1    Toonkel, R.L.2    Powell, C.A.3
  • 13
    • 33746875641 scopus 로고    scopus 로고
    • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    • 10.1056/NEJMoa060467 1:CAS:528:DC%2BD28XotVKnu7g%3D 16899777
    • A Potti S Mukherjee R Petersen, et al. 2006 A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer N Engl J Med 355 570 580 10.1056/NEJMoa060467 1:CAS:528:DC%2BD28XotVKnu7g%3D 16899777
    • (2006) N Engl J Med , vol.355 , pp. 570-580
    • Potti, A.1    Mukherjee, S.2    Petersen, R.3
  • 14
    • 49149129916 scopus 로고    scopus 로고
    • Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
    • 10.1038/nm.1790 1:CAS:528:DC%2BD1cXptlKltr8%3D 18641660
    • K Shedden JM Taylor SA Enkemann, et al. 2008 Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study Nat Med 14 822 827 10.1038/nm.1790 1:CAS:528:DC%2BD1cXptlKltr8%3D 18641660
    • (2008) Nat Med , vol.14 , pp. 822-827
    • Shedden, K.1    Taylor, J.M.2    Enkemann, S.A.3
  • 15
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • 10.1200/JCO.2007.15.0375 1:CAS:528:DC%2BD1cXpvVWmtLg%3D 18506025 This phase 3 study demonstrated that in patients with adenocarcinoma and large cell histology, overall survival was superior for cisplatin/pemetrexed versus cisplatin/gemcitabine compared to patients with squamous cell histology, for whom the opposite results were seen
    • GV Scagliotti P Parikh J von Pawel, et al. 2008 Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer J Clin Oncol 26 3543 3551 10.1200/JCO.2007.15.0375 1:CAS:528:DC%2BD1cXpvVWmtLg%3D 18506025 This phase 3 study demonstrated that in patients with adenocarcinoma and large cell histology, overall survival was superior for cisplatin/pemetrexed versus cisplatin/gemcitabine compared to patients with squamous cell histology, for whom the opposite results were seen
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 16
    • 64049115311 scopus 로고    scopus 로고
    • The differential efficacy of pemetrexed according to NSCLC histology: A review of two phase III studies
    • 10.1634/theoncologist.2008-0232 1:CAS:528:DC%2BD1MXltFektrc%3D 19221167
    • G Scagliotti N Hanna F Fossella, et al. 2009 The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies Oncologist 14 253 263 10.1634/theoncologist.2008-0232 1:CAS:528: DC%2BD1MXltFektrc%3D 19221167
    • (2009) Oncologist , vol.14 , pp. 253-263
    • Scagliotti, G.1    Hanna, N.2    Fossella, F.3
  • 17
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • 10.1016/S0140-6736(09)61497-5 1:CAS:528:DC%2BD1MXhtlSru7jL 19767093
    • T Ciuleanu T Brodowicz C Zielinski, et al. 2009 Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study Lancet 374 1432 1440 10.1016/S0140-6736(09)61497-5 1:CAS:528:DC%2BD1MXhtlSru7jL 19767093
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 18
    • 34547138888 scopus 로고    scopus 로고
    • Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer
    • 10.1002/ijc.22738 1:CAS:528:DC%2BD2sXotlequ7k%3D 17417781
    • T Takenaka I Yoshino H Kouso, et al. 2007 Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer Int J Cancer 121 895 900 10.1002/ijc.22738 1:CAS:528:DC%2BD2sXotlequ7k%3D 17417781
    • (2007) Int J Cancer , vol.121 , pp. 895-900
    • Takenaka, T.1    Yoshino, I.2    Kouso, H.3
  • 19
    • 67349275022 scopus 로고    scopus 로고
    • Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel
    • 10.1016/j.lungcan.2008.09.002 18977553
    • K Azuma T Sasada A Kawahara, et al. 2009 Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel Lung Cancer 64 326 333 10.1016/j.lungcan.2008.09.002 18977553
    • (2009) Lung Cancer , vol.64 , pp. 326-333
    • Azuma, K.1    Sasada, T.2    Kawahara, A.3
  • 20
    • 0035988959 scopus 로고    scopus 로고
    • Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
    • 1:CAS:528:DC%2BD38XmtVWhsLw%3D 12114432
    • RV Lord J Brabender D Gandara, et al. 2002 Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer Clin Cancer Res 8 2286 2291 1:CAS:528: DC%2BD38XmtVWhsLw%3D 12114432
    • (2002) Clin Cancer Res , vol.8 , pp. 2286-2291
    • Lord, R.V.1    Brabender, J.2    Gandara, D.3
  • 21
    • 34447573875 scopus 로고    scopus 로고
    • Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: A phase III trial in non-small-cell lung cancer
    • 10.1200/JCO.2006.09.7915 1:CAS:528:DC%2BD2sXosValtLk%3D 17602080
    • M Cobo D Isla B Massuti, et al. 2007 Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: a phase III trial in non-small-cell lung cancer J Clin Oncol 25 2747 2754 10.1200/JCO.2006.09.7915 1:CAS:528:DC%2BD2sXosValtLk%3D 17602080
    • (2007) J Clin Oncol , vol.25 , pp. 2747-2754
    • Cobo, M.1    Isla, D.2    Massuti, B.3
  • 22
    • 33750579074 scopus 로고    scopus 로고
    • RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer
    • 10.1200/JCO.2006.06.1101 1:CAS:528:DC%2BD28XhtFynsr3K 16966686
    • G Bepler I Kusmartseva S Sharma, et al. 2006 RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer J Clin Oncol 24 4731 4737 10.1200/JCO.2006.06.1101 1:CAS:528:DC%2BD28XhtFynsr3K 16966686
    • (2006) J Clin Oncol , vol.24 , pp. 4731-4737
    • Bepler, G.1    Kusmartseva, I.2    Sharma, S.3
  • 23
    • 12144285914 scopus 로고    scopus 로고
    • Ribonucleotide reductase messenger RNA expression and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients
    • 10.1158/1078-0432.CCR-03-0156 1:CAS:528:DC%2BD2cXhsVCqu7o%3D 14977831
    • R Rosell KD Danenberg V Alberola, et al. 2004 Ribonucleotide reductase messenger RNA expression and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients Clin Cancer Res 10 1318 1325 10.1158/1078-0432.CCR-03-0156 1:CAS:528:DC%2BD2cXhsVCqu7o%3D 14977831
    • (2004) Clin Cancer Res , vol.10 , pp. 1318-1325
    • Rosell, R.1    Danenberg, K.D.2    Alberola, V.3
  • 24
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
    • 1:CAS:528:DC%2BD2MXlvVSqtbc%3D 15795320
    • E Giovannetti V Mey S Nannizzi, et al. 2005 Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells Mol Pharmacol 68 110 118 1:CAS:528: DC%2BD2MXlvVSqtbc%3D 15795320
    • (2005) Mol Pharmacol , vol.68 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3
  • 25
    • 58949097480 scopus 로고    scopus 로고
    • Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer
    • 10.1097/JTO.0b013e3181874936 18827606
    • G Bepler KE Sommers A Cantor, et al. 2008 Clinical efficacy and predictive molecular markers of neoadjuvant gemcitabine and pemetrexed in resectable non-small cell lung cancer J Thorac Oncol 3 1112 1118 10.1097/JTO.0b013e3181874936 18827606
    • (2008) J Thorac Oncol , vol.3 , pp. 1112-1118
    • Bepler, G.1    Sommers, K.E.2    Cantor, A.3
  • 26
    • 34447567414 scopus 로고    scopus 로고
    • Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer
    • 10.1200/JCO.2006.08.2099 1:CAS:528:DC%2BD2sXosValtLg%3D 17602079
    • G Simon A Sharma X Li, et al. 2007 Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer J Clin Oncol 25 2741 2746 10.1200/JCO.2006.08.2099 1:CAS:528: DC%2BD2sXosValtLg%3D 17602079
    • (2007) J Clin Oncol , vol.25 , pp. 2741-2746
    • Simon, G.1    Sharma, A.2    Li, X.3
  • 27
    • 68949213744 scopus 로고    scopus 로고
    • Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
    • 10.1038/onc.2009.199 1:CAS:528:DC%2BD1MXpvFCrsrc%3D 19680294
    • FR Hirsch M Varella-Garcia F Cappuzzo 2009 Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer Oncogene 28 Suppl 1 S32 S37 10.1038/onc.2009.199 1:CAS:528:DC%2BD1MXpvFCrsrc%3D 19680294
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • Hirsch, F.R.1    Varella-Garcia, M.2    Cappuzzo, F.3
  • 28
    • 68949209102 scopus 로고    scopus 로고
    • Overview of molecular testing in non-small-cell lung cancer: Mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors
    • 10.1038/onc.2009.197 1:CAS:528:DC%2BD1MXpvFCktb4%3D 19680292
    • T John G Liu MS Tsao 2009 Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors Oncogene 28 Suppl 1 S14 S23 10.1038/onc.2009.197 1:CAS:528: DC%2BD1MXpvFCktb4%3D 19680292
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • John, T.1    Liu, G.2    Tsao, M.S.3
  • 29
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
    • 10.1200/JCO.2004.08.158 1:CAS:528:DC%2BD2cXptlCku7g%3D 15020612
    • VA Miller MG Kris N Shah, et al. 2004 Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer J Clin Oncol 22 1103 1109 10.1200/JCO.2004.08.158 1:CAS:528:DC%2BD2cXptlCku7g%3D 15020612
    • (2004) J Clin Oncol , vol.22 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 30
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • 10.1056/NEJMoa040938 1:CAS:528:DC%2BD2cXktF2js7c%3D 15118073
    • TJ Lynch DW Bell R Sordella, et al. 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2129 2139 10.1056/NEJMoa040938 1:CAS:528:DC%2BD2cXktF2js7c%3D 15118073
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 31
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D 15118125
    • JG Paez PA Janne JC Lee, et al. 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500 10.1126/science.1099314 1:CAS:528:DC%2BD2cXksVGmsbs%3D 15118125
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 32
    • 19944433797 scopus 로고    scopus 로고
    • The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers
    • 1:CAS:528:DC%2BD2MXht1ynt7c%3D 15709185
    • M Tokumo S Toyooka K Kiura, et al. 2005 The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers Clin Cancer Res 11 1167 1173 1:CAS:528: DC%2BD2MXht1ynt7c%3D 15709185
    • (2005) Clin Cancer Res , vol.11 , pp. 1167-1173
    • Tokumo, M.1    Toyooka, S.2    Kiura, K.3
  • 33
    • 73949154122 scopus 로고    scopus 로고
    • Genetic abnormalities of the EGFR pathway in African American patients with non-small-cell lung cancer
    • 10.1200/JCO.2009.23.1431 1:CAS:528:DC%2BC3cXhtVWit7k%3D 19786660
    • RS Leidner P Fu B Clifford, et al. 2009 Genetic abnormalities of the EGFR pathway in African American patients with non-small-cell lung cancer J Clin Oncol 27 5620 5626 10.1200/JCO.2009.23.1431 1:CAS:528:DC%2BC3cXhtVWit7k%3D 19786660
    • (2009) J Clin Oncol , vol.27 , pp. 5620-5626
    • Leidner, R.S.1    Fu, P.2    Clifford, B.3
  • 34
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • 10.1038/nrc2088 1:CAS:528:DC%2BD2sXitVGrsbo%3D 17318210
    • SV Sharma DW Bell J Settleman DA Haber 2007 Epidermal growth factor receptor mutations in lung cancer Nat Rev Cancer 7 169 181 10.1038/nrc2088 1:CAS:528:DC%2BD2sXitVGrsbo%3D 17318210
    • (2007) Nat Rev Cancer , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 35
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • 10.1200/JCO.2005.02.857 1:CAS:528:DC%2BD2MXhtVKgtbzO 16043828
    • DA Eberhard BE Johnson LC Amler, et al. 2005 Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib J Clin Oncol 23 5900 5909 10.1200/JCO.2005.02.857 1:CAS:528:DC%2BD2MXhtVKgtbzO 16043828
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 36
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • 10.1200/JCO.2007.14.8924 1:CAS:528:DC%2BD1cXhtF2it7bF 18626007
    • CQ Zhu G da Cunha Santos K Ding, et al. 2008 Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 J Clin Oncol 26 4268 4275 10.1200/JCO.2007.14. 8924 1:CAS:528:DC%2BD1cXhtF2it7bF 18626007
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 37
    • 74949117339 scopus 로고    scopus 로고
    • Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer
    • 10.1158/1078-0432.CCR-09-1660 1:CAS:528:DC%2BC3cXot1Sh 20028749
    • IJ Dahabreh H Linardou F Siannis, et al. 2010 Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer Clin Cancer Res 16 291 303 10.1158/1078-0432.CCR-09-1660 1:CAS:528:DC%2BC3cXot1Sh 20028749
    • (2010) Clin Cancer Res , vol.16 , pp. 291-303
    • Dahabreh, I.J.1    Linardou, H.2    Siannis, F.3
  • 38
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK 19692680 The I-PASS study showed that gefitinib is superior to carboplatin-paclitaxel as first-line treatment in Asian patients with advanced lung adenocarcinoma and no/limited smoking history. PFS was significantly longer for EGFR-mutant tumors when treated with gefitinib versus chemotherapy, while the opposite held true for EGFR wild-type tumors
    • TS Mok YL Wu S Thongprasert, et al. 2009 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 947 957 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK 19692680 The I-PASS study showed that gefitinib is superior to carboplatin-paclitaxel as first-line treatment in Asian patients with advanced lung adenocarcinoma and no/limited smoking history. PFS was significantly longer for EGFR-mutant tumors when treated with gefitinib versus chemotherapy, while the opposite held true for EGFR wild-type tumors
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 39
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • 10.1016/S1470-2045(09)70364-X 1:CAS:528:DC%2BC3cXhtlGgtbo%3D 20022809
    • T Mitsudomi S Morita Y Yatabe, et al. 2010 Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial Lancet Oncol 11 121 128 10.1016/S1470-2045(09)70364-X 1:CAS:528:DC%2BC3cXhtlGgtbo%3D 20022809
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 40
    • 77649222572 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: Data from the randomized phase III INTEREST trial
    • 10.1200/JCO.2009.24.3030 1:CAS:528:DC%2BC3cXksVyrsbY%3D 20038723 The INTEREST trial showed that patients with EGFR-mutated tumors had longer PFS with gefitinib versus docetaxel in the second-line setting
    • JY Douillard FA Shepherd V Hirsh, et al. 2010 Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial J Clin Oncol 28 744 752 10.1200/JCO.2009.24.3030 1:CAS:528:DC%2BC3cXksVyrsbY%3D 20038723 The INTEREST trial showed that patients with EGFR-mutated tumors had longer PFS with gefitinib versus docetaxel in the second-line setting
    • (2010) J Clin Oncol , vol.28 , pp. 744-752
    • Douillard, J.Y.1    Shepherd, F.A.2    Hirsh, V.3
  • 41
    • 70349475409 scopus 로고    scopus 로고
    • SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC
    • abstract 8001. In the phase 3 SATURN trial, erlotinib was shown to produce prolonged PFS and overall survival when compared with placebo in the maintenance setting after first-line chemotherapy. The benefit was modest overall but very striking in patients with EGFR-mutant tumors.
    • • Cappuzzo TC, Stelmakh L, Cicenas S, et al.: SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC. J Clin Oncol 2009, 27(15s): abstract 8001. In the phase 3 SATURN trial, erlotinib was shown to produce prolonged PFS and overall survival when compared with placebo in the maintenance setting after first-line chemotherapy. The benefit was modest overall but very striking in patients with EGFR-mutant tumors.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Cappuzzo, T.C.1    Stelmakh, L.2    Cicenas, S.3
  • 42
    • 77949886293 scopus 로고    scopus 로고
    • Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
    • 10.1200/JCO.2009.25.2890 1:CAS:528:DC%2BC3cXktF2lsbY%3D 20100958
    • S Khambata-Ford CT Harbison LL Hart, et al. 2010 Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer J Clin Oncol 28 918 927 10.1200/JCO.2009.25.2890 1:CAS:528: DC%2BC3cXktF2lsbY%3D 20100958
    • (2010) J Clin Oncol , vol.28 , pp. 918-927
    • Khambata-Ford, S.1    Harbison, C.T.2    Hart, L.L.3
  • 43
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • 10.1056/NEJMoa044238 1:CAS:528:DC%2BD2MXhsFCiurk%3D 15728811
    • S Kobayashi TJ Boggon T Dayaram, et al. 2005 EGFR mutation and resistance of non-small-cell lung cancer to gefitinib N Engl J Med 352 786 792 10.1056/NEJMoa044238 1:CAS:528:DC%2BD2MXhsFCiurk%3D 15728811
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 44
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • 10.1371/journal.pmed.0020073 15737014
    • W Pao VA Miller KA Politi, et al. 2005 Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med 2 e73 10.1371/journal.pmed.0020073 15737014
    • (2005) PLoS Med , vol.2 , pp. 73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 45
    • 73349096261 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • 10.1158/1078-0432.CCR-09-0189 1:CAS:528:DC%2BD1MXhsFGgurrN 20008850
    • PS Hammerman PA Janne BE Johnson 2009 Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer Clin Cancer Res 15 7502 7509 10.1158/1078-0432.CCR-09-0189 1:CAS:528: DC%2BD1MXhsFGgurrN 20008850
    • (2009) Clin Cancer Res , vol.15 , pp. 7502-7509
    • Hammerman, P.S.1    Janne, P.A.2    Johnson, B.E.3
  • 46
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • 10.1038/nature08622 1:CAS:528:DC%2BD1MXhs1SktbvI 20033049
    • W Zhou D Ercan L Chen, et al. 2009 Novel mutant-selective EGFR kinase inhibitors against EGFR T790M Nature 462 1070 1074 10.1038/nature08622 1:CAS:528:DC%2BD1MXhs1SktbvI 20033049
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3
  • 47
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • 10.1056/NEJMoa0800668 1:CAS:528:DC%2BD1cXovFSqtbc%3D 18596266
    • S Maheswaran LV Sequist S Nagrath, et al. 2008 Detection of mutations in EGFR in circulating lung-cancer cells N Engl J Med 359 366 377 10.1056/NEJMoa0800668 1:CAS:528:DC%2BD1cXovFSqtbc%3D 18596266
    • (2008) N Engl J Med , vol.359 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 48
    • 70349376330 scopus 로고    scopus 로고
    • Molecular predictive and prognostic markers in non-small-cell lung cancer
    • 10.1016/S1470-2045(09)70155-X 1:CAS:528:DC%2BD1MXhtFOqurjE 19796752
    • LE Coate T John MS Tsao FA Shepherd 2009 Molecular predictive and prognostic markers in non-small-cell lung cancer Lancet Oncol 10 1001 1010 10.1016/S1470-2045(09)70155-X 1:CAS:528:DC%2BD1MXhtFOqurjE 19796752
    • (2009) Lancet Oncol , vol.10 , pp. 1001-1010
    • Coate, L.E.1    John, T.2    Tsao, M.S.3    Shepherd, F.A.4
  • 49
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • 10.1093/jnci/dji112 1:CAS:528:DC%2BD2MXjvFymt70%3D 15870435
    • F Cappuzzo FR Hirsch E Rossi, et al. 2005 Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer J Natl Cancer Inst 97 643 655 10.1093/jnci/dji112 1:CAS:528: DC%2BD2MXjvFymt70%3D 15870435
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 50
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • 10.1016/S0140-6736(09)60569-9 1:CAS:528:DC%2BD1MXltlaqurs%3D 19410716
    • R Pirker JR Pereira A Szczesna, et al. 2009 Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial Lancet 373 1525 1531 10.1016/S0140-6736(09)60569-9 1:CAS:528:DC%2BD1MXltlaqurs%3D 19410716
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 51
    • 33750962024 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
    • 10.1200/JCO.2006.06.3958 1:CAS:528:DC%2BD28Xht1GnurzF 17075123
    • FR Hirsch M Varella-Garcia PA Bunn Jr, et al. 2006 Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer J Clin Oncol 24 5034 5042 10.1200/JCO.2006.06.3958 1:CAS:528:DC%2BD28Xht1GnurzF 17075123
    • (2006) J Clin Oncol , vol.24 , pp. 5034-5042
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3
  • 52
    • 39749144726 scopus 로고    scopus 로고
    • Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-Cell Lung Cancer Working Group: Standardization for use in the clinical trial setting
    • 10.1200/JCO.2007.12.9858 18281673
    • DA Eberhard G Giaccone BE Johnson 2008 Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-Cell Lung Cancer Working Group: standardization for use in the clinical trial setting J Clin Oncol 26 983 994 10.1200/JCO.2007.12.9858 18281673
    • (2008) J Clin Oncol , vol.26 , pp. 983-994
    • Eberhard, D.A.1    Giaccone, G.2    Johnson, B.E.3
  • 53
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • 10.1056/NEJMra0707704 1:CAS:528:DC%2BD1cXjt1ahsL4%3D 18337605
    • F Ciardiello G Tortora 2008 EGFR antagonists in cancer treatment N Engl J Med 358 1160 1174 10.1056/NEJMra0707704 1:CAS:528:DC%2BD1cXjt1ahsL4%3D 18337605
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 54
    • 34347393745 scopus 로고    scopus 로고
    • Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: A multicohort cross-institutional study
    • 10.1093/jnci/djk195 1:CAS:528:DC%2BD2sXns1als7o%3D 17551144
    • F Taguchi B Solomon V Gregorc, et al. 2007 Mass spectrometry to classify non-small-cell lung cancer patients for clinical outcome after treatment with epidermal growth factor receptor tyrosine kinase inhibitors: a multicohort cross-institutional study J Natl Cancer Inst 99 838 846 10.1093/jnci/djk195 1:CAS:528:DC%2BD2sXns1als7o%3D 17551144
    • (2007) J Natl Cancer Inst , vol.99 , pp. 838-846
    • Taguchi, F.1    Solomon, B.2    Gregorc, V.3
  • 55
    • 77649114574 scopus 로고    scopus 로고
    • Genetic and proteomic features associated with survival after treatment with erlotinib in first-line therapy of non-small cell lung cancer in Eastern Cooperative Oncology Group 3503
    • 10.1097/JTO.0b013e3181c8cbd9 20035238
    • JM Amann JW Lee H Roder, et al. 2010 Genetic and proteomic features associated with survival after treatment with erlotinib in first-line therapy of non-small cell lung cancer in Eastern Cooperative Oncology Group 3503 J Thorac Oncol 5 169 178 10.1097/JTO.0b013e3181c8cbd9 20035238
    • (2010) J Thorac Oncol , vol.5 , pp. 169-178
    • Amann, J.M.1    Lee, J.W.2    Roder, H.3
  • 56
    • 77955474478 scopus 로고    scopus 로고
    • VeriStrat® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab
    • Dec 24 (Epub ahead of print)
    • Carbone DP, Salmon JS, Billheimer D, et al.: VeriStrat® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab. Lung Cancer 2009 Dec 24 (Epub ahead of print).
    • (2009) Lung Cancer
    • Carbone, D.P.1    Salmon, J.S.2    Billheimer, D.3
  • 57
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • 10.1371/journal.pmed.0020017 15696205
    • W Pao TY Wang GJ Riely, et al. 2005 KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib PLoS Med 2 e17 10.1371/journal.pmed.0020017 15696205
    • (2005) PLoS Med , vol.2 , pp. 17
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 58
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • 10.1016/S1470-2045(08)70206-7 1:CAS:528:DC%2BD1cXhtFOmurvJ 18804418
    • H Linardou IJ Dahabreh D Kanaloupiti, et al. 2008 Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer Lancet Oncol 9 962 972 10.1016/S1470-2045(08)70206-7 1:CAS:528:DC%2BD1cXhtFOmurvJ 18804418
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3
  • 59
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • 10.1038/nature05945 1:CAS:528:DC%2BD2sXosVSrtrs%3D 17625570 This study identified the most recent oncogene found in NSCLC, EML4-ALK fusion gene
    • M Soda YL Choi M Enomoto, et al. 2007 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer Nature 448 561 566 10.1038/nature05945 1:CAS:528:DC%2BD2sXosVSrtrs%3D 17625570 This study identified the most recent oncogene found in NSCLC, EML4-ALK fusion gene
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 60
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • 10.1016/j.cell.2007.11.025 1:CAS:528:DC%2BD1cXksFGnsQ%3D%3D 18083107
    • K Rikova A Guo Q Zeng, et al. 2007 Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer Cell 131 1190 1203 10.1016/j.cell.2007.11.025 1:CAS:528:DC%2BD1cXksFGnsQ%3D%3D 18083107
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 61
    • 63949086127 scopus 로고    scopus 로고
    • KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    • 10.1158/1078-0432.CCR-08-3248 1:CAS:528:DC%2BD1MXltFOrtbY%3D 19383809
    • K Takeuchi YL Choi Y Togashi, et al. 2009 KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer Clin Cancer Res 15 3143 3149 10.1158/1078-0432.CCR-08- 3248 1:CAS:528:DC%2BD1MXltFOrtbY%3D 19383809
    • (2009) Clin Cancer Res , vol.15 , pp. 3143-3149
    • Takeuchi, K.1    Choi, Y.L.2    Togashi, Y.3
  • 62
    • 48549098388 scopus 로고    scopus 로고
    • Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    • 10.1158/0008-5472.CAN-07-6158 1:CAS:528:DC%2BD1cXnvFOqsbY%3D 18593892
    • YL Choi K Takeuchi M Soda, et al. 2008 Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer Cancer Res 68 4971 4976 10.1158/0008-5472.CAN-07-6158 1:CAS:528:DC%2BD1cXnvFOqsbY%3D 18593892
    • (2008) Cancer Res , vol.68 , pp. 4971-4976
    • Choi, Y.L.1    Takeuchi, K.2    Soda, M.3
  • 63
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • 10.1073/pnas.0805381105 1:CAS:528:DC%2BD1cXhsFCmtb7F 19064915
    • M Soda S Takada K Takeuchi, et al. 2008 A mouse model for EML4-ALK-positive lung cancer Proc Natl Acad Sci U S A 105 19893 19897 10.1073/pnas.0805381105 1:CAS:528:DC%2BD1cXhsFCmtb7F 19064915
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 64
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-small-cell lung cancer
    • 10.1200/JCO.2009.23.6661 1:CAS:528:DC%2BD1MXht1WisbvE 19667260
    • L Horn W Pao 2009 EML4-ALK: honing in on a new target in non-small-cell lung cancer J Clin Oncol 27 4232 4235 10.1200/JCO.2009.23.6661 1:CAS:528:DC%2BD1MXht1WisbvE 19667260
    • (2009) J Clin Oncol , vol.27 , pp. 4232-4235
    • Horn, L.1    Pao, W.2
  • 65
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    • 10.1097/JTO.0b013e31815e8b60 18166835
    • K Inamura K Takeuchi Y Togashi, et al. 2008 EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers J Thorac Oncol 3 13 17 10.1097/JTO.0b013e31815e8b60 18166835
    • (2008) J Thorac Oncol , vol.3 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 66
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    • 10.1158/1078-0432.CCR-09-0802 1:CAS:528:DC%2BD1MXpvFeitrY%3D 19671850
    • SJ Rodig M Mino-Kenudson S Dacic, et al. 2009 Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population Clin Cancer Res 15 5216 5223 10.1158/1078-0432.CCR-09-0802 1:CAS:528:DC%2BD1MXpvFeitrY%3D 19671850
    • (2009) Clin Cancer Res , vol.15 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 67
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • 10.1200/JCO.2009.22.6993 1:CAS:528:DC%2BD1MXht1WisbvF 19667264
    • AT Shaw BY Yeap M Mino-Kenudson, et al. 2009 Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK J Clin Oncol 27 4247 4253 10.1200/JCO.2009.22.6993 1:CAS:528:DC%2BD1MXht1WisbvF 19667264
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 68
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    • 10.1158/1078-0432.CCR-08-0168 1:CAS:528:DC%2BD1cXnvFyks7s%3D 18594010
    • JP Koivunen C Mermel K Zejnullahu, et al. 2008 EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer Clin Cancer Res 14 4275 4283 10.1158/1078-0432.CCR-08-0168 1:CAS:528:DC%2BD1cXnvFyks7s%3D 18594010
    • (2008) Clin Cancer Res , vol.14 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3
  • 69
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • 10.1158/0008-5472.CAN-07-6186 1:CAS:528:DC%2BD1cXltlSlsbg%3D 18451166
    • U McDermott AJ Iafrate NS Gray, et al. 2008 Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors Cancer Res 68 3389 3395 10.1158/0008-5472.CAN-07-6186 1:CAS:528:DC%2BD1cXltlSlsbg%3D 18451166
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3
  • 70
    • 75749088881 scopus 로고    scopus 로고
    • Clinical activity of the oral ALK and MET inhibitor PF-02341066 in non-small lung cancer (NSCLC) with EML4-ALK translocations
    • CD Shaw AT AJ Iafrate BJ Dezube, et al. 2009 Clinical activity of the oral ALK and MET inhibitor PF-02341066 in non-small lung cancer (NSCLC) with EML4-ALK translocations J Thorac Oncol 4 S305 S306
    • (2009) J Thorac Oncol , vol.4
    • Shaw, A.T.C.D.1    Iafrate, A.J.2    Dezube, B.J.3
  • 71
    • 58149147368 scopus 로고    scopus 로고
    • Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer
    • 10.1158/1078-0432.CCR-08-0071 1:CAS:528:DC%2BD1cXhtF2nur3E 18829470
    • L Toschi PA Janne 2008 Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer Clin Cancer Res 14 5941 5946 10.1158/1078-0432.CCR-08-0071 1:CAS:528: DC%2BD1cXhtF2nur3E 18829470
    • (2008) Clin Cancer Res , vol.14 , pp. 5941-5946
    • Toschi, L.1    Janne, P.A.2
  • 72
    • 73549118124 scopus 로고    scopus 로고
    • MET receptor tyrosine kinase
    • 10.1097/01.JTO.0000361752.86918.09 19861919
    • L Faoro GM Cervantes E El-Hashani R Salgia 2009 MET receptor tyrosine kinase J Thorac Oncol 4 S1064 S1065 10.1097/01.JTO.0000361752.86918.09 19861919
    • (2009) J Thorac Oncol , vol.4
    • Faoro, L.1    Cervantes, G.M.2    El-Hashani, E.3    Salgia, R.4
  • 73
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • 10.1200/JCO.2008.19.1635 19255323
    • F Cappuzzo A Marchetti M Skokan, et al. 2009 Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients J Clin Oncol 27 1667 1674 10.1200/JCO.2008.19.1635 19255323
    • (2009) J Clin Oncol , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3
  • 74
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • 10.1093/annonc/mdn635 1:STN:280:DC%2BD1M7jtlWlsg%3D%3D 18836087
    • F Cappuzzo PA Janne M Skokan, et al. 2009 MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients Ann Oncol 20 298 304 10.1093/annonc/mdn635 1:STN:280: DC%2BD1M7jtlWlsg%3D%3D 18836087
    • (2009) Ann Oncol , vol.20 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3
  • 75
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • 10.1126/science.1141478 1:CAS:528:DC%2BD2sXltlOjt7g%3D 17463250
    • JA Engelman K Zejnullahu T Mitsudomi, et al. 2007 MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling Science 316 1039 1043 10.1126/science.1141478 1:CAS:528:DC%2BD2sXltlOjt7g%3D 17463250
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 76
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • 10.1016/j.ccr.2009.11.022 1:CAS:528:DC%2BC3cXkvFKgs7Y%3D 20129249
    • AB Turke K Zejnullahu YL Wu, et al. 2010 Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC Cancer Cell 17 77 88 10.1016/j.ccr.2009.11.022 1:CAS:528:DC%2BC3cXkvFKgs7Y%3D 20129249
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.L.3
  • 77
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • 10.3816/CLC.2009.n.039 1:CAS:528:DC%2BD1MXhtVSms7bO 19632948
    • KS Nguyen S Kobayashi DB Costa 2009 Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway Clin Lung Cancer 10 281 289 10.3816/CLC.2009.n.039 1:CAS:528:DC%2BD1MXhtVSms7bO 19632948
    • (2009) Clin Lung Cancer , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3
  • 78
    • 84870003706 scopus 로고    scopus 로고
    • Arqule Joins the Phase III Club. http://seekingalpha.com/article/198568- arqule-joins-the-phase-iii-club. Accessed April 13, 2010.
    • Arqule Joins the Phase III Club
  • 79
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI 17167137
    • A Sandler R Gray MC Perry, et al. 2006 Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2542 2550 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI 17167137
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 80
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
    • Feb 11 (Epub ahead of print)
    • Reck M, von Pawel J, Zatloukal P, et al.: Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010 Feb 11 (Epub ahead of print).
    • (2010) Ann Oncol
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 81
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study
    • 10.1158/1078-0432.CCR-07-1154 1:CAS:528:DC%2BD1cXislSrs7c%3D 18316562
    • A Dowlati R Gray AB Sandler, et al. 2008 Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study Clin Cancer Res 14 1407 1412 10.1158/1078-0432.CCR-07-1154 1:CAS:528:DC%2BD1cXislSrs7c%3D 18316562
    • (2008) Clin Cancer Res , vol.14 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3
  • 82
    • 74249092481 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
    • 10.1038/sj.bjc.6605483 1:CAS:528:DC%2BC3cXhtFOltA%3D%3D 20010945
    • N Murukesh C Dive GC Jayson 2010 Biomarkers of angiogenesis and their role in the development of VEGF inhibitors Br J Cancer 102 8 18 10.1038/sj.bjc.6605483 1:CAS:528:DC%2BC3cXhtFOltA%3D%3D 20010945
    • (2010) Br J Cancer , vol.102 , pp. 8-18
    • Murukesh, N.1    Dive, C.2    Jayson, G.C.3
  • 83
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
    • 10.1200/JCO.2009.25.4482 1:CAS:528:DC%2BC3cXktF2ltr8%3D 20085937
    • SE Dahlberg AB Sandler JR Brahmer, et al. 2010 Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599 J Clin Oncol 28 949 954 10.1200/JCO.2009.25.4482 1:CAS:528: DC%2BC3cXktF2ltr8%3D 20085937
    • (2010) J Clin Oncol , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3
  • 85
    • 77950999338 scopus 로고    scopus 로고
    • Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology: A paradigm shift
    • 10.1097/JTO.0b013e3181d57f6e 20357614
    • WD Travis N Rekhtman GJ Riley, et al. 2010 Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology: a paradigm shift J Thorac Oncol 5 411 414 10.1097/JTO.0b013e3181d57f6e 20357614
    • (2010) J Thorac Oncol , vol.5 , pp. 411-414
    • Travis, W.D.1    Rekhtman, N.2    Riley, G.J.3
  • 86
    • 70149110218 scopus 로고    scopus 로고
    • Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: An important role for mutations in minor clones
    • 1:CAS:528:DC%2BD1MXhtFKrsb7I 19794967
    • A Marchetti M Milella L Felicioni, et al. 2009 Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones Neoplasia 11 1084 1092 1:CAS:528:DC%2BD1MXhtFKrsb7I 19794967
    • (2009) Neoplasia , vol.11 , pp. 1084-1092
    • Marchetti, A.1    Milella, M.2    Felicioni, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.