Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model

Biochemical and Biophysical Research Communications

Volumn 399, Issue 4, 2010, Pages 629-636

  Zhao, Yong ^a   Guo, Chengshan ^a   Hwang, David ^a   Lin, Brian ^a   Dingeldein, Michael ^a   Mihailescu, Dan ^a   Sam, Susan ^a   Sidhwani, Seema ^a   Zhang, Yongkang ^a   Jain, Sumit ^a   Skidgel, Randal A ^a   Prabhakar, Bellur S ^a   Mazzone, Theodore ^a   Holterman, Mark J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Autoimmunity; Beta cell destruction; Humanized mouse model; INKT cells; T lymphocytes; Type 1 diabetes

Indexed keywords

CD1D ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; INTERLEUKIN 2 RECEPTOR GAMMA; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DESTRUCTION; CELL EXPANSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NORMAL HUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; CELL MOTION; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; RADIATION RESPONSE; SPLEEN; TRANSLATIONAL RESEARCH; TRANSPLANTATION;

ANIMALS; CELL MOVEMENT; CHEMOKINE CXCL12; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMANS; INSULIN-SECRETING CELLS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED NOD; MICE, SCID; SPLEEN; T-LYMPHOCYTES; TRANSLATIONAL RESEARCH; TRANSLATIONAL MEDICAL RESEARCH;

MUS;

EID: 77956266386     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.128     Document Type: Article

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