Polypill: Lights and shadows

Current Hypertension Reports

Volumn 12, Issue 4, 2010, Pages 276-281

  Teo, Koon K ^a   Liang, Yan ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Cardiovascular disease; Polycap; Polypill; Secondary and primary prevention; The Indian Polycap Study (TIPS)

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ATENOLOL; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROCHLOROTHIAZIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; RAMIPRIL; SIMVASTATIN; THIAZIDE DIURETIC AGENT;

BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; HUMAN; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; LOW DRUG DOSE; POLYPHARMACY; PRIMARY PREVENTION; REVIEW; RISK REDUCTION; SECONDARY PREVENTION; STROKE; THROMBOCYTE AGGREGATION INHIBITION;

BLOOD PRESSURE; CARDIOVASCULAR DISEASES; HUMANS; POLYPHARMACY; PRIMARY PREVENTION; RISK FACTORS; SECONDARY PREVENTION;

EID: 77956264573     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-010-0127-1     Document Type: Review

References (32)

1. KA Fox PG Steg KA Eagle, et al. 2007 Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006 JAMA 297 1892 1900 10.1001/jama.297.17.1892 1:CAS:528:DC%2BD2sXkvFKru7s%3D 17473299
2. CP Cannon 2009 Can the polypill save the world from heart disease? Lancet 373 1313 1314 10.1016/S0140-6736(09)60652-8 19339044
3. TA Gaziano LH Opie MC Weinstein 2006 Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis Lancet 368 679 686 10.1016/S0140-6736(06)69252-0 1:CAS:528:DC%2BD28XotlWmtLk%3D 16920473
4. J Hippisley-Cox C Coupland 2005 Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis BMJ 330 1059 1063 10.1136/bmj.330.7499.1059 1:CAS:528: DC%2BD2MXkvFyrs7s%3D 15879390
5. JD Spence 2008 Polypill: for Pollyanna Int J Stroke 3 92 97 10.1111/j.1747-4949.2008.00169.x 18706002
6. E Lonn S Yusuf 2009 Polypill: the evidence and the promise Curr Opin Lipidol 20 453 459 10.1097/MOL.0b013e32833305a3 1:CAS:528:DC%2BD1MXhsVKls7%2FJ 19884824 This is a recent review on the polypill
7. S Yusuf S Hawken S Ounpuu INTERHEARY Study Investigators, et al. 2004 Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART Study): case-control study Lancet 364 937 952 10.1016/S0140-6736(04)17018-9 15364185
8. Antithrombotic Trialists' Collaboration 2002 Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients BMJ 324 71 86 10.1136/bmj.324.7329. 71
9. S Yusuf R Peto J Lewis, et al. 1985 Beta-blockade during and after myocardial infarction: an overview of the randomized trials Prog Cardiovasc Dis 27 335 371 10.1016/S0033-0620(85)80003-7 1:STN:280:DyaL2M7ktFSitw%3D%3D 2858114
10. S Yusuf P Sleight J Pogue, et al. 2000 Effects of an angiotensin- converting enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators N Engl J Med 342 145 153 10.1056/NEJM200001203420301 1:STN:280:DC%2BD3c%2Fpt1emug%3D%3D 10639539
11. Cholesterol Treatment Trialists' (CTT) Collaborators 2005 Efficacy and safety of cholesterol lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomized trials of statins Lancet 366 1267 1278 10.1016/S0140-6736(05)67394-1
12. ES Ford UA Ajani JB Croft, et al. 2007 Explaining the decrease in U.S. deaths from coronary disease, 1980-2000 N Engl J Med 356 2388 2398 10.1056/NEJMsa053935 1:CAS:528:DC%2BD2sXmt1Wnsbs%3D 17554120
13. World Health Statistics 2009. Table 2. Cause-specific mortality and morbidity. http://www.who.int/whosis/whostat/EN-WHS09-Table2.pdf. Accessed 5 August 2009.
14. S Yusuf 2002 Two decades of progress in preventing vascular disease Lancet 360 2 3 10.1016/S0140-6736(02)09358-3 12114031
15. NJ Wald MR Law 2003 A strategy to reduce cardiovascular disease by more than 80% BMJ 326 1419 1424 10.1136/bmj.326.7404.1419 1:STN:280: DC%2BD3szgtFSgsw%3D%3D 12829553
16. MR Law NJ Wald AR Rudnicka 2003 Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis BMJ 326 1423 1429 10.1136/bmj.326.7404.1423 1:CAS:528:DC%2BD3sXlvFCjsLY%3D 12829554
17. MR Law NJ Wald JK Morris, et al. 2003 Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials BMJ 326 1427 1434 10.1136/bmj.326.7404.1427 1:CAS:528:DC%2BD3sXlvFCjsLc%3D 12829555
18. DS Wald M Law JK Morris 2002 Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis BMJ 325 1202 1208 10.1136/bmj.325.7374.1202 12446535
19. E Lonn S Yusuf MJ Arnold Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators, et al. 2006 Homocysteine lowering with folic acid and B vitamins in vascular disease N Engl J Med 354 1567 1577 10.1056/NEJMoa060900 1:CAS:528:DC%2BD28XjsVKgs7s%3D 16531613
20. DG Hackam LA Leiter AT Yan, et al. 2007 Missed opportunities for the secondary prevention of cardiovascular disease in Canada Can J Cardiol 23 1124 1130 18060097
21. DT Ko HM Krumholz Y Wang, et al. 2007 Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada Circulation 115 196 203 10.1161/CIRCULATIONAHA.106. 657601 17190861
22. K Kotseva D Wood G De Backer, et al. 2009 Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries Lancet 373 929 940 10.1016/S0140-6736(09)60330-5 19286092
23. SG Goodman W Huang AT Yan, et al. 2009 The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes Am Heart J 158 193 201 10.1016/j.ahj.2009.06.003 19619694
24. S Mendis D Abegunde S Yusuf, et al. 2005 WHO study on Prevention of REcurrences of Myocardial Infarction and StrokE (WHO-PREMISE) Bull World Health Organ 83 820 829 16302038
25. S Mendis K Fukino A Cameron, et al. 2007 The availability and affordability of selected essential medicines for chronic diseases in six low- and middle-income countries Bull World Health Organ 85 279 288 10.2471/BLT.06.033647 17546309
26. CA Jackevicius M Mamdani JV Tu 2002 Adherence with statin therapy in elderly patients with and without acute coronary syndromes JAMA 288 462 467 10.1001/jama.288.4.462 12132976
27. JS Benner RJ Glynn H Mogun, et al. 2002 Long-term persistence in use of statin therapy in elderly patients JAMA 288 455 461 10.1001/jama.288.4.455 12132975
28. GC Fonarow WJ French PD Frederick 2009 Trends in the use of lipid-lowering medications at discharge in patients with acute myocardial infarction: 1998 to 2006 Am Heart J 157 185 194 10.1016/j.ahj.2008.09.001 19081417
29. GB Oliveira A Avezum FA Anderson Jr, et al. 2007 Use of proven therapies in non-ST-elevation acute coronary syndromes according to evidence-based risk stratification Am Heart J 153 493 499 10.1016/j.ahj.2007.01.001 1:CAS:528:DC%2BD2sXjsVWit70%3D 17383284
30. SH Simpson DT Eurich SR Majumdar, et al. 2006 A meta-analysis of the association between adherence to drug therapy and mortality BMJ 333 15 20 10.1136/bmj.38875.675486.55 16790458
31. CA Jackevicius P Li JV Tu 2008 Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction Circulation 117 1028 1036 10.1161/CIRCULATIONAHA.107.706820 18299512
32. Indian Polycap Study (TIPS) S Yusuf P Pais, et al. 2009 Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial Lancet 373 1341 1351 10.1016/S0140-6736(09)60611-5 1:CAS:528:DC%2BD1MXkslKmt7s%3D 19339045 This was the first clinical trial establishing the clinical application of the polypill