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Volumn 10, Issue 5, 2010, Pages 370-379

Immune intervention in children with type 1 diabetes

Author keywords

Cell regeneration; AntiCD20; AntiCD3; Autoantigens; Children; GAD65; Immune intervention; Type 1 diabetes; Vitamin D

Indexed keywords

ALPHA INTERFERON; CALCITRIOL; DACLIZUMAB; DIAPEP277; DIAZOXIDE; ETANERCEPT; EXENDIN 4; GLUTAMATE DECARBOXYLASE 65; HEAT SHOCK PROTEIN; INSULIN; INSULIN B CHAIN FRAGMENT; INSULIN DERIVATIVE; ISLET NEOGENESIS ASSOCIATED PROTEIN; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINAMIDE; OTELIXIZUMAB; PANCREAS POLYPEPTIDE; PLACEBO; RITUXIMAB; ROQUINIMEX; TEPLIZUMAB; UNCLASSIFIED DRUG;

EID: 77956263517     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-010-0138-y     Document Type: Review
Times cited : (4)

References (56)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group [no authors listed]
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group [no authors listed]. N Engl J Med 1993, 329:977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 0028118757 scopus 로고
    • Declining incidence of nephropathy in insulin-dependent diabetes mellitus
    • 10.1056/NEJM199401063300103 8259139
    • M Bojestig HJ Arnqvist G Hermansson, et al. 1994 Declining incidence of nephropathy in insulin-dependent diabetes mellitus N Engl J Med 330 15 18 10.1056/NEJM199401063300103 8259139
    • (1994) N Engl J Med , vol.330 , pp. 15-18
    • Bojestig, M.1    Arnqvist, H.J.2    Hermansson, G.3
  • 3
    • 0018642122 scopus 로고
    • Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes
    • 10.1136/bmj.2.6200.1257 117878
    • S Madsbad KG Alberti C Binder, et al. 1979 Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes Br Med J 2 1257 1259 10.1136/bmj.2.6200.1257 117878
    • (1979) Br Med J , vol.2 , pp. 1257-1259
    • Madsbad, S.1    Alberti, K.G.2    Binder, C.3
  • 4
    • 0041666293 scopus 로고    scopus 로고
    • Beta-cell function and the development of diabetes-related complications in the Diabetes Control and Complications Trial
    • 10.2337/diacare.26.3.832 12610045
    • MW Steffes S Sibley M Jackson W Thomas 2003 Beta-cell function and the development of diabetes-related complications in the Diabetes Control and Complications Trial Diabetes Care 26 832 836 10.2337/diacare.26.3.832 12610045
    • (2003) Diabetes Care , vol.26 , pp. 832-836
    • Steffes, M.W.1    Sibley, S.2    Jackson, M.3    Thomas, W.4
  • 6
    • 33745788583 scopus 로고    scopus 로고
    • Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes
    • 10.1007/s00125-006-0308-2 16802132
    • JJ Meier JC Lin AE Butler, et al. 2006 Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes Diabetologia 49 1838 1844 10.1007/s00125-006-0308-2 16802132
    • (2006) Diabetologia , vol.49 , pp. 1838-1844
    • Meier, J.J.1    Lin, J.C.2    Butler, A.E.3
  • 7
    • 35448986170 scopus 로고    scopus 로고
    • The replication of beta cells in normal physiology, in disease and for therapy
    • 10.1038/ncpendmet0647 17955017
    • PC Butler JJ Meier AE Butler A Bhushan 2007 The replication of beta cells in normal physiology, in disease and for therapy Nat Clin Pract Endocrinol Metab 3 758 768 10.1038/ncpendmet0647 17955017
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 758-768
    • Butler, P.C.1    Meier, J.J.2    Butler, A.E.3    Bhushan, A.4
  • 8
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • 10.1016/S0140-6736(01)05415-0 11476858
    • MA Atkinson GS Eisenbarth 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 221 229 10.1016/S0140-6736(01) 05415-0 11476858
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 9
    • 0020683402 scopus 로고
    • Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children
    • 10.1136/bmj.286.6360.176
    • J Ludvigsson L Heding G Lieden, et al. 1983 Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children Br Med J (Clin Res Ed) 286 176 178 10.1136/bmj.286.6360.176
    • (1983) Br Med J (Clin Res Ed) , vol.286 , pp. 176-178
    • Ludvigsson, J.1    Heding, L.2    Lieden, G.3
  • 10
    • 0021359025 scopus 로고
    • Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset
    • 10.1126/science.6367043 6367043
    • CR Stiller J Dupré M Gent, et al. 1984 Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset Science 223 1362 1367 10.1126/science.6367043 6367043
    • (1984) Science , vol.223 , pp. 1362-1367
    • Stiller, C.R.1    Dupré, J.2    Gent, M.3
  • 11
    • 0022348847 scopus 로고
    • Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus
    • 3878262
    • GS Eisenbarth S Srikanta R Jackson, et al. 1985 Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus Diabetes Res 2 271 276 3878262
    • (1985) Diabetes Res , vol.2 , pp. 271-276
    • Eisenbarth, G.S.1    Srikanta, S.2    Jackson, R.3
  • 12
    • 0025294001 scopus 로고
    • A trial of nicotinamide in newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus
    • 10.1007/BF00404097 2144835
    • HP Chase N Butler-Simon S Garg, et al. 1990 A trial of nicotinamide in newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus Diabetologia 33 444 446 10.1007/BF00404097 2144835
    • (1990) Diabetologia , vol.33 , pp. 444-446
    • Chase, H.P.1    Butler-Simon, N.2    Garg, S.3
  • 13
    • 0029078738 scopus 로고
    • Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study)
    • 10.1007/s001250050362 7556988
    • P Pozzilli N Visalli A Signore, et al. 1995 Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study) Diabetologia 38 848 852 10.1007/s001250050362 7556988
    • (1995) Diabetologia , vol.38 , pp. 848-852
    • Pozzilli, P.1    Visalli, N.2    Signore, A.3
  • 14
    • 15444353015 scopus 로고    scopus 로고
    • Low dose linomide in type i juvenile diabetes of recent onset: A randomised placebo-controlled double blind trial
    • 10.1007/s001250051028 9754822
    • R Coutant P Landais M Rosilio, et al. 1998 Low dose linomide in type I juvenile diabetes of recent onset: a randomised placebo-controlled double blind trial Diabetologia 41 1040 1046 10.1007/s001250051028 9754822
    • (1998) Diabetologia , vol.41 , pp. 1040-1046
    • Coutant, R.1    Landais, P.2    Rosilio, M.3
  • 15
    • 0035019505 scopus 로고    scopus 로고
    • Treatment with antioxidants at onset of type 1 diabetes in children: A randomized, double-blind placebo-controlled study
    • 10.1002/dmrr.176 11307178
    • J Ludvigsson U Samuelsson C Johansson L Stenhammar 2001 Treatment with antioxidants at onset of type 1 diabetes in children: a randomized, double-blind placebo-controlled study Diabetes Metab Res Rev 17 131 136 10.1002/dmrr.176 11307178
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 131-136
    • Ludvigsson, J.1    Samuelsson, U.2    Johansson, C.3    Stenhammar, L.4
  • 16
    • 0034924964 scopus 로고    scopus 로고
    • Photopheresis at onset of type 1 diabetes: A randomised, double blind, placebo controlled trial
    • 10.1136/adc.85.2.149 11466190
    • J Ludvigsson U Samuelsson J Ernerudh, et al. 2001 Photopheresis at onset of type 1 diabetes: a randomised, double blind, placebo controlled trial Arch Dis Child 85 149 154 10.1136/adc.85.2.149 11466190
    • (2001) Arch Dis Child , vol.85 , pp. 149-154
    • Ludvigsson, J.1    Samuelsson, U.2    Ernerudh, J.3
  • 17
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • 10.1016/S0140-6736(01)06801-5 11734230
    • I Raz D Elias A Avron, et al. 2001 Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial Lancet 358 1749 1753 10.1016/S0140-6736(01)06801-5 11734230
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3
  • 18
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • 10.2337/diabetes.54.6.1763 15919798
    • KC Herold SE Gitelman U Masharani, et al. 2005 A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes Diabetes 54 1763 1769 10.2337/diabetes.54.6.1763 15919798
    • (2005) Diabetes , vol.54 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3
  • 19
    • 20544443927 scopus 로고    scopus 로고
    • Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
    • 10.1056/NEJMoa043980 15972866
    • B Keymeulen E Vandemeulebroucke AG Ziegler, et al. 2005 Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes N Engl J Med 352 2598 2608 10.1056/NEJMoa043980 15972866
    • (2005) N Engl J Med , vol.352 , pp. 2598-2608
    • Keymeulen, B.1    Vandemeulebroucke, E.2    Ziegler, A.G.3
  • 20
    • 21344461521 scopus 로고    scopus 로고
    • Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
    • 10.1016/j.jdiacomp.2004.12.003 15993359
    • CD Agardh CM Cilio A Lethagen, et al. 2005 Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes J Diabetes Complications 19 238 246 10.1016/j.jdiacomp.2004.12.003 15993359
    • (2005) J Diabetes Complications , vol.19 , pp. 238-246
    • Agardh, C.D.1    Cilio, C.M.2    Lethagen, A.3
  • 21
    • 34247170807 scopus 로고    scopus 로고
    • Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    • 10.1056/NEJMoa065213 17429083
    • CM Larsen M Faulenbach A Vaag, et al. 2007 Interleukin-1-receptor antagonist in type 2 diabetes mellitus N Engl J Med 356 1517 1526 10.1056/NEJMoa065213 17429083
    • (2007) N Engl J Med , vol.356 , pp. 1517-1526
    • Larsen, C.M.1    Faulenbach, M.2    Vaag, A.3
  • 22
    • 55249110198 scopus 로고    scopus 로고
    • GAD treatment and insulin secretion in recent-onset type 1 diabetes
    • 10.1056/NEJMoa0804328 18843118
    • J Ludvigsson M Faresjö M Hjorth, et al. 2008 GAD treatment and insulin secretion in recent-onset type 1 diabetes N Engl J Med 359 1909 1920 10.1056/NEJMoa0804328 18843118
    • (2008) N Engl J Med , vol.359 , pp. 1909-1920
    • Ludvigsson, J.1    Faresjö, M.2    Hjorth, M.3
  • 23
    • 77949266510 scopus 로고    scopus 로고
    • Four-year metabolic outcome of a randomised controlled CD-3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
    • 10.1007/s00125-009-1644-9 20225393
    • B Keymeulen M Walter C Mathieu, et al. 2010 Four-year metabolic outcome of a randomised controlled CD-3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass Diabetologia 53 614 623 10.1007/s00125-009-1644-9 20225393
    • (2010) Diabetologia , vol.53 , pp. 614-623
    • Keymeulen, B.1    Walter, M.2    Mathieu, C.3
  • 24
    • 67649933375 scopus 로고    scopus 로고
    • Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years
    • 10.1016/j.clim.2009.04.007 19443276
    • KC Herold S Gitelman C Greenbaum, et al. 2009 Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years Clin Immunol 132 166 173 10.1016/j.clim.2009.04.007 19443276
    • (2009) Clin Immunol , vol.132 , pp. 166-173
    • Herold, K.C.1    Gitelman, S.2    Greenbaum, C.3
  • 25
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial
    • The Diabetes Control and Complications Trial Research Group [no authors listed]
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group [no authors listed]. Ann Intern Med 1998, 128:517-523.
    • (1998) Ann Intern Med , vol.128 , pp. 517-523
  • 26
    • 70449480577 scopus 로고    scopus 로고
    • Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
    • 10.1056/NEJMoa0904452 19940299
    • MD Pescovitz CJ Greenbaum H Krause-Steinrauf, et al. 2009 Rituximab, B-lymphocyte depletion, and preservation of beta-cell function N Engl J Med 361 2143 2152 10.1056/NEJMoa0904452 19940299
    • (2009) N Engl J Med , vol.361 , pp. 2143-2152
    • Pescovitz, M.D.1    Greenbaum, C.J.2    Krause-Steinrauf, H.3
  • 27
    • 77949450368 scopus 로고    scopus 로고
    • The use of ustekinumab in autoimmune disease
    • 10.1517/14712591003724670 20218921
    • C Ryan B Thrash RB Warren A Menter 2010 The use of ustekinumab in autoimmune disease Expert Opin Biol Ther 10 587 604 10.1517/14712591003724670 20218921
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 587-604
    • Ryan, C.1    Thrash, B.2    Warren, R.B.3    Menter, A.4
  • 28
    • 77950636402 scopus 로고    scopus 로고
    • Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes
    • 10.2337/dc09-1349 20067954
    • PA Gottlieb S Quinlan H Krause-Steinrauf, et al. 2010 Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new- onset type 1 diabetes Diabetes Care 33 826 832 10.2337/dc09-1349 20067954
    • (2010) Diabetes Care , vol.33 , pp. 826-832
    • Gottlieb, P.A.1    Quinlan, S.2    Krause-Steinrauf, H.3
  • 29
    • 67650079482 scopus 로고    scopus 로고
    • Etanercept treatment in children with new-onset type 1 diabetes: Pilot randomized, placebo-controlled, double-blind study
    • 10.2337/dc09-0054 19366957
    • L Mastrandrea J Yu T Behrens, et al. 2009 Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study Diabetes Care 32 1244 1249 10.2337/dc09-0054 19366957
    • (2009) Diabetes Care , vol.32 , pp. 1244-1249
    • Mastrandrea, L.1    Yu, J.2    Behrens, T.3
  • 30
    • 77649108168 scopus 로고    scopus 로고
    • Blockade of interleukin 1 in type 1 diabetes mellitus
    • 10.1038/nrendo.2009.271 20173777
    • T Mandrup-Poulsen L Pickersgill M Donath 2010 Blockade of interleukin 1 in type 1 diabetes mellitus Nat Rev Endocrinol 6 158 166 10.1038/nrendo.2009.271 20173777
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 158-166
    • Mandrup-Poulsen, T.1    Pickersgill, L.2    Donath, M.3
  • 31
    • 64749084427 scopus 로고    scopus 로고
    • C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    • 10.1001/jama.2009.470 19366777
    • CE Couri MC Oliveira AB Stracieri, et al. 2009 C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus JAMA 301 1573 1579 10.1001/jama.2009.470 19366777
    • (2009) JAMA , vol.301 , pp. 1573-1579
    • Couri, C.E.1    Oliveira, M.C.2    Stracieri, A.B.3
  • 32
    • 34548265826 scopus 로고    scopus 로고
    • Immune intervention at diagnosis-should we treat children to preserve beta-cell function?
    • 10.1111/j.1399-5448.2007.00299.x 17727383
    • J Ludvigsson 2007 Immune intervention at diagnosis-should we treat children to preserve beta-cell function? Pediatr Diabetes 8 Suppl 6 34 39 10.1111/j.1399-5448.2007.00299.x 17727383
    • (2007) Pediatr Diabetes , vol.8 , Issue.SUPPL. 6 , pp. 34-39
    • Ludvigsson, J.1
  • 33
    • 15444353015 scopus 로고    scopus 로고
    • Low dose linomide in type i juvenile diabetes of recent onset: A randomised placebo-controlled double blind trial
    • 10.1007/s001250051028 9754822
    • R Coutant P Landais M Rosilio, et al. 1998 Low dose linomide in type I juvenile diabetes of recent onset: a randomised placebo-controlled double blind trial Diabetologia 41 1040 1046 10.1007/s001250051028 9754822
    • (1998) Diabetologia , vol.41 , pp. 1040-1046
    • Coutant, R.1    Landais, P.2    Rosilio, M.3
  • 34
    • 67650072951 scopus 로고    scopus 로고
    • Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes
    • 10.2337/dc08-2029 19564474
    • KI Rother RJ Brown MM Morales, et al. 2009 Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes Diabetes Care 32 1250 1255 10.2337/dc08-2029 19564474
    • (2009) Diabetes Care , vol.32 , pp. 1250-1255
    • Rother, K.I.1    Brown, R.J.2    Morales, M.M.3
  • 35
    • 70449415668 scopus 로고    scopus 로고
    • Autologous umbilical cord blood transfusion in very young children with type 1 diabetes
    • 10.2337/dc09-0967 19875605
    • MJ Haller CH Wasserfall KM McGrail, et al. 2009 Autologous umbilical cord blood transfusion in very young children with type 1 diabetes Diabetes Care 32 2041 2046 10.2337/dc09-0967 19875605
    • (2009) Diabetes Care , vol.32 , pp. 2041-2046
    • Haller, M.J.1    Wasserfall, C.H.2    McGrail, K.M.3
  • 36
    • 0025058568 scopus 로고
    • Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
    • 10.1073/pnas.87.4.1576 2406723
    • D Elias D Markovits T Reshef, et al. 1990 Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein Proc Natl Acad Sci U S A 87 1576 1580 10.1073/pnas.87.4.1576 2406723
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1576-1580
    • Elias, D.1    Markovits, D.2    Reshef, T.3
  • 37
    • 34249786263 scopus 로고    scopus 로고
    • Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: Two prospective, randomized, double-blind phase II trials
    • 10.1002/dmrr.707 17103487
    • NC Schloot G Meierhoff C Lengyel, et al. 2007 Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials Diabetes Metab Res Rev 23 276 285 10.1002/dmrr.707 17103487
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 276-285
    • Schloot, N.C.1    Meierhoff, G.2    Lengyel, C.3
  • 38
    • 75349111902 scopus 로고    scopus 로고
    • Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients
    • 10.1016/j.jaut.2009.08.004 19744828
    • C Pfleger G Meierhoff H Kolb NC Schloot 2010 Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients J Autoimmun 34 127 135 10.1016/j.jaut.2009.08.004 19744828
    • (2010) J Autoimmun , vol.34 , pp. 127-135
    • Pfleger, C.1    Meierhoff, G.2    Kolb, H.3    Schloot, N.C.4
  • 39
    • 69249212422 scopus 로고    scopus 로고
    • Immune modulation in type 1 diabetes mellitus using DiaPep277: A short review and update of recent clinical trial results
    • 10.1002/dmrr.942 19267355
    • R Eldor S Kassem I Raz 2009 Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results Diabetes Metab Res Rev 25 316 320 10.1002/dmrr.942 19267355
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 316-320
    • Eldor, R.1    Kassem, S.2    Raz, I.3
  • 40
    • 57249096985 scopus 로고    scopus 로고
    • Adequate doses of autoantigen administered using the appropriate route may create tolerance and stop autoimmunity
    • 10.1007/s00125-008-1211-9 19005640
    • J Ludvigsson 2009 Adequate doses of autoantigen administered using the appropriate route may create tolerance and stop autoimmunity Diabetologia 52 175 176 10.1007/s00125-008-1211-9 19005640
    • (2009) Diabetologia , vol.52 , pp. 175-176
    • Ludvigsson, J.1
  • 41
    • 69549089992 scopus 로고    scopus 로고
    • Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1
    • 10.2337/dc08-2140 19487644
    • JM Sosenko JP Palmer L Rafkin-Mervis, et al. 2009 Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1 Diabetes Care 32 1603 1607 10.2337/dc08-2140 19487644
    • (2009) Diabetes Care , vol.32 , pp. 1603-1607
    • Sosenko, J.M.1    Palmer, J.P.2    Rafkin-Mervis, L.3
  • 42
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1
    • 10.2337/diacare.28.7.1630 15855569
    • JS Skyler JP Krischer J Wolfsdorf, et al. 2005 Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1 Diabetes Care 28 1068 1076 10.2337/diacare.28.7.1630 15855569
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3
  • 43
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial
    • 10.1016/S0140-6736(08)61309-4 18814906
    • K Näntö-Salonen A Kupila S Simell, et al. 2008 Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial Lancet 372 1746 1755 10.1016/S0140-6736(08)61309-4 18814906
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Näntö-Salonen, K.1    Kupila, A.2    Simell, S.3
  • 44
    • 77952243765 scopus 로고    scopus 로고
    • Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
    • 10.1016/j.jaut.2009.10.005 19931408
    • T Orban K Farkas H Jalahej, et al. 2010 Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy J Autoimmun 34 408 415 10.1016/j.jaut.2009.10.005 19931408
    • (2010) J Autoimmun , vol.34 , pp. 408-415
    • Orban, T.1    Farkas, K.2    Jalahej, H.3
  • 45
    • 67349116493 scopus 로고    scopus 로고
    • GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes
    • 10.1007/s00125-009-1371-2 19404608
    • CD Agardh KF Lynch M Palmér, et al. 2009 GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes Diabetologia 52 1363 1368 10.1007/s00125-009-1371-2 19404608
    • (2009) Diabetologia , vol.52 , pp. 1363-1368
    • Agardh, C.D.1    Lynch, K.F.2    Palmér, M.3
  • 46
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
    • 10.1016/S0140-6736(04)15786-3 15043959
    • EA Gale PJ Bingley CL Emmett T Collier 2004 European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes Lancet 363 925 931 10.1016/S0140-6736(04)15786-3 15043959
    • (2004) Lancet , vol.363 , pp. 925-931
    • Gale, E.A.1    Bingley, P.J.2    Emmett, C.L.3    Collier, T.4
  • 47
    • 4444322687 scopus 로고    scopus 로고
    • Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes
    • 10.2337/diacare.27.9.2191 15333483
    • E Ortqvist E Björk M Wallensteen, et al. 2004 Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes Diabetes Care 27 2191 2197 10.2337/diacare.27.9.2191 15333483
    • (2004) Diabetes Care , vol.27 , pp. 2191-2197
    • Ortqvist, E.1    Björk, E.2    Wallensteen, M.3
  • 48
    • 77649267697 scopus 로고    scopus 로고
    • Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control
    • 10.2337/dc09-1436 20028939
    • MA Radtke I Nermoen M Kollind, et al. 2010 Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control Diabetes Care 33 589 594 10.2337/dc09-1436 20028939
    • (2010) Diabetes Care , vol.33 , pp. 589-594
    • Radtke, M.A.1    Nermoen, I.2    Kollind, M.3
  • 49
    • 23044436849 scopus 로고    scopus 로고
    • Vitamin D and type 1 diabetes mellitus: State of the art
    • 10.1016/j.tem.2005.06.004 15996876
    • C Mathieu K Badenhoop 2005 Vitamin D and type 1 diabetes mellitus: state of the art Trends Endocrinol Metab 16 261 266 10.1016/j.tem.2005.06.004 15996876
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 261-266
    • Mathieu, C.1    Badenhoop, K.2
  • 50
    • 77956263961 scopus 로고    scopus 로고
    • No effect of the 1alpha, 25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes
    • 10.2337/dc09-2297 20357369
    • M Walter T Kaupper K Adler, et al. 2010 No effect of the 1alpha, 25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes Diabetes Care 33 1443 1448 10.2337/dc09-2297 20357369
    • (2010) Diabetes Care , vol.33 , pp. 1443-1448
    • Walter, M.1    Kaupper, T.2    Adler, K.3
  • 51
    • 0035122304 scopus 로고    scopus 로고
    • Regulation of beta-cell mass by hormones and growth factors
    • 10.2337/diabetes.50.2007.S25 11272193
    • JH Nielsen ED Galsgaard A Møldrup, et al. 2001 Regulation of beta-cell mass by hormones and growth factors Diabetes 50 Suppl 1 S25 S29 10.2337/diabetes.50.2007.S25 11272193
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Nielsen, J.H.1    Galsgaard, E.D.2    Møldrup, A.3
  • 52
    • 72249103423 scopus 로고    scopus 로고
    • Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes
    • 10.2337/dc09-0773 19808924
    • KI Rother LM Spain RA Wesley, et al. 2009 Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes Diabetes Care 32 2251 2257 10.2337/dc09-0773 19808924
    • (2009) Diabetes Care , vol.32 , pp. 2251-2257
    • Rother, K.I.1    Spain, L.M.2    Wesley, R.A.3
  • 53
    • 70350570465 scopus 로고    scopus 로고
    • Effects of therapy in type 1 and type 2 diabetes mellitus with a peptide derived from islet neogenesis associated protein (INGAP)
    • 10.1002/dmrr.999 19626663
    • KM Dungan JB Buse RE Ratner 2009 Effects of therapy in type 1 and type 2 diabetes mellitus with a peptide derived from islet neogenesis associated protein (INGAP) Diabetes Metab Res Rev 25 558 565 10.1002/dmrr.999 19626663
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 558-565
    • Dungan, K.M.1    Buse, J.B.2    Ratner, R.E.3
  • 54
    • 53349174600 scopus 로고    scopus 로고
    • Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years
    • 10.1002/dmrr.871 18613248
    • M Nordwall J Ludvigsson 2008 Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years Diabetes Metab Res Rev 24 472 479 10.1002/dmrr.871 18613248
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 472-479
    • Nordwall, M.1    Ludvigsson, J.2
  • 55
    • 0017740757 scopus 로고
    • C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control
    • 10.1111/j.1651-2227.1977.tb07830.x 402787
    • J Ludvigsson LG Heding Y Larsson E Leander 1977 C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control Acta Paediatr Scand 66 177 184 10.1111/j.1651-2227.1977.tb07830.x 402787
    • (1977) Acta Paediatr Scand , vol.66 , pp. 177-184
    • Ludvigsson, J.1    Heding, L.G.2    Larsson, Y.3    Leander, E.4
  • 56
    • 73349090572 scopus 로고    scopus 로고
    • C-peptide an adequate endpoint in type 1 diabetes
    • 10.1002/dmrr.1035 19877135
    • J Ludvigsson 2009 C-peptide an adequate endpoint in type 1 diabetes Diabetes Metab Res Rev 25 691 693 10.1002/dmrr.1035 19877135
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 691-693
    • Ludvigsson, J.1


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