Treatment with antioxidants at onset of type 1 diabetes in children: A randomized, double-blind placebo-controlled study

Diabetes/Metabolism Research and Reviews

Volumn 17, Issue 2, 2001, Pages 131-136

  Ludvigsson, J ^a   Samuelsson, U ^a   Johansson, C ^a   Stenhammar, L ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Antioxidants; C peptide; Children; Immune intervention; Type 1 diabetes

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; C PEPTIDE; FREE RADICAL; HEMOGLOBIN A1C; IMMUNOLOGIC AGENT; INSULIN; NICOTINAMIDE; PLACEBO; SELENIUM;

ADOLESCENT; ARTICLE; CELL FUNCTION; CELL PROTECTION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG COST; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLIC BALANCE; NORMAL VALUE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TABLET FORMULATION;

ADOLESCENT; AGE OF ONSET; ANTIOXIDANTS; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFANT; INSULIN; MALE; PLACEBOS; TIME FACTORS;

EID: 0035019505     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.176     Document Type: Article

References (48)

1. Pathological anatomy of the pancreas in juvenile diabetes mellitus
2. C-peptide in juvenile diabetes beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control
3. The effect of strict metabolic control on residual beta-cell function, a controlled study
4. Socio-psychological factors and metabolic control in juvenile diabetes
5. Prevalence of residual beta cell function and its metabolic consequences in type 1 (insulin-dependent) diabetes
6. Diabetic control and microvascular complications: The near-normoglycaemic experience
7. C-peptide revisited - New physiological effects and therapeutic implications
8. C-peptide improves autonomic nerve function in IDDM patients
9. Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus
10. Effects of cyclosporin immuno-suppression in insulin-dependent diabetes of recent onset
11. Increase of remission rate in newly diagnosed type 1 diabetes subjects treated with azathioprine
12. Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes
13. Cyclosporin in diabetes mellitus
14. Low dose linomide in type 1 juvenile diabetes of recent onset: A randomized placebo-controlled double blind trial
15. Nicotinamide treatment in the prevention of Insulin-Dependent Diabetes Mellitus
16. Free radicals and diabetes
17. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications
18. Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis
19. Differentiation of beta cells from ductal cells and acceleration of this process by nicotinamide: Ultrastructural study on the non-obese diabetic (BOD) mouse with overt diabetes
20. Nicotinamide increases C-peptide secretion in patients with recent onset type 1 diabetes
21. Effect of nicotinamide treatment on the residual insulin secretion in type 1 (insulin-dependent) diabetic patients
22. Effect of dietary vitamin E on the vitamin E status in the BB rat during development and after the onset of diabetes
23. Vitamin E delays diabetes onset in the non-obese diabetic mouse
24. Delayed onset and decreased incidence of diabetes in BB rats fed free radical scavengers
25. Vitamin E supplementation reduces the incidence of diabetes but not insulitis in NODS mice
26. Will the 'good fairies' please prove to us that vitamin E lessens human degenerative disease?
27. Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes (the IMDIAB IV study)
28. Effect of Vitamin C supplementation on hepatic cytochrome P450 mixed function oxidase activity in streptozotocin-diabetic rats
29. C-peptide in children with juvenile diabetes. A preliminary report
30. Insulin treatment: A non-stop revolution
31. Radioimmunological determination of human C-peptide in serum
32. Methodological aspects on C-peptide measurements
33. Beta cell function in children with diabetes
34. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
35. Insulin antibodies in insulin-dependent diabetes before insulin treatment
36. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM
37. Establishing the significance and optimal intake of dietary antioxidants: The biomarker concept
38. Can protein kinase C and vitamin E prevent the development of diabetic vascular complications?
39. Molecular mechanisms of beta-cell destruction in IDDM. The role of nicotinamide
40. A population based strategy to prevent insulin-dependent diabetes using Nicotinamide
41. Theory and practice of Nicotinamide trials in pre-type 1 diabetes
42. Nitric oxide: Cytotoxicity versus cytoprotection - How, why, when and where
43. Determinants of the selective toxicity of alloxan to the pancreatic B cell
44. Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM
45. C-peptide in diabetic children after stimulation with glucagon compared with fasting C-peptide levels in non-diabetic children
46. Recent progress in the treatment of diabetes mellitus
47. Diabetes mellitus: 1. Improving control in type 1 diabetes