Diagnosis and management of right-sided heart failure in subjects supported with left ventricular assist devices

Current Treatment Options in Cardiovascular Medicine

Volumn 12, Issue 5, 2010, Pages 420-430

  Romano, Matthew A ^a   Cowger, Jennifer ^b   Aaronson, Keith D ^b   Pagani, Francis D ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; DIURETIC AGENT; HYDRALAZINE; ILOPROST; MILRINONE; NITRATE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; SILDENAFIL;

AIR EMBOLISM; CARDIOVASCULAR RISK; CORONARY ARTERY RECANALIZATION; DRUG HALF LIFE; DRUG MECHANISM; HEART ASSIST DEVICE; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE FAILURE; HUMAN; LEFT VENTRICULAR ASSIST DEVICE; PERIOPERATIVE PERIOD; PEROPERATIVE CARE; POSTOPERATIVE CARE; PROGNOSIS; PULMONARY HYPERTENSION; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRICUSPID ANNULOPLASTY; TRICUSPID VALVE REGURGITATION;

EID: 77956262393     PISSN: 10928464     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11936-010-0091-8     Document Type: Review

References (48)

1. KD Aaronson, et al. 2002 Left ventricular assist device therapy improves utilization of donor hearts J Am Coll Cardiol 39 1247 1254 10.1016/S0735- 1097(02)01751-5 11955839
2. LW Miller, et al. 2007 Use of a continuous-flow device in patients awaiting heart transplantation N Engl J Med 357 885 896 10.1056/NEJMoa067758 1:CAS:528:DC%2BD2sXpvVyltb0%3D 17761592
3. EA Rose, et al. 2001 Long-term mechanical left ventricular assistance for end-stage heart failure N Engl J Med 345 1435 1443 10.1056/NEJMoa012175 1:STN:280:DC%2BD38%2FmsFGnsQ%3D%3D 11794191
4. MS Slaughter, et al. 2009 Advanced heart failure treated with continuous-flow left ventricular assist device N Engl J Med 361 2241 2251 10.1056/NEJMoa0909938 1:CAS:528:DC%2BD1MXhsFWgs7%2FE 19920051 This landmark multicenter controlled study of HeartMate II versus XVE (both manufactured by Thoratec, Pleasanton, CA) LVAD support examined outcomes in patients ineligible for transplantation. This article demonstrates better outcomes in HeartMate II-supported patients than in the XVE cohort.
5. NC Dang VK Topkara M Mercando, et al. 2006 Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure J Heart Lung Transplant 25 1 6 10.1016/j.healun.2005.07.008 16399523
6. MC Deng, et al. 2005 Mechanical Circulatory Support Device Database of the International Society for Heart and Lung Transplantation: Third Annual Report-2005 J Heart Lung Transplant 24 1182 1187 10.1016/j.healun.2005.07.002 16143231
7. K Fukamachi PM McCarthy NG Smedira, et al. 1999 Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion Ann Thorac Surg 68 2181 2184 10.1016/S0003-4975(99)00753-5 1:STN:280:DC%2BD3c%2Fotlaruw%3D%3D 10616999
8. Y Ochiai, et al. 2002 Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients Circulation 106 Suppl 1 198 202
9. JC Matthews TM Koelling FD Pagani KD Aaronson 2008 The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates J Am Coll Cardiol 51 2163 2172 10.1016/j.jacc.2008.03.009 18510965 This large single-center cohort study of RVF risk in LVAD candidates generated a risk score to predict RVF and survival post LVAD.
10. NF Voelkel RA Quaife LA Leinwand, et al. 2006 National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure: Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 1883 1891 10.1161/ CIRCULATIONAHA.106.632208 17060398
11. A Mebazaa, et al. 2004 Acute right ventricular failure-from pathophysiology to new treatments Intensive Care Med 30 185 196 10.1007/s00134-003-2025-3 14618229
12. RP Kondo 2006 Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform J Physiol 571 131 10.1113/jphysiol.2005.101428 1:CAS:528:DC%2BD28XislKmsr4%3D 16357014
13. GY Wang DT McCloskey S Turcato, et al. 2006 Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium Am J Physiol Heart Circ Physiol 291 2013 2017 10.1152/ajpheart.00167.2006
14. MN Kavarana, et al. 2002 Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem Ann Thorac Surg 73 745 750 10.1016/S0003-4975(01)03406-3 11899176
15. DJ Farrar JD Hill DG Pennington, et al. 1997 Preoperative and postoperative comparison of patients with univentricular and biventricular support with the thoratec ventricular assist device as a bridge to cardiac transplantation J Thorac Cardiovasc Surg 113 202 209 10.1016/S0022-5223(97) 70416-1 1:STN:280:DyaK2s7kvVylsg%3D%3D 9011691
16. RL Kormos, et al. 1996 Transplant candidate's clinical status rather than right ventricular function defines need for univentricular versus biventricular support J Thorac Cardiovasc Surg 111 773 782 10.1016/S0022-5223(96)70337-9 1:STN:280:DyaK287osVemsg%3D%3D 8614137
17. JC Matthews, et al. 2010 Model for end-stage liver disease score predicts left ventricular assist device operative transfusion requirements, morbidity, and mortality Circulation 121 214 220 10.1161/CIRCULATIONAHA.108.838656 20048215 This study examined the use of the preoperative Model for End-State Liver Disease (MELD) score to predict perioperative bleeding risk and subsequent postoperative outcomes in LVAD candidates. This was a single-center study with InterMACS validation of predicted outcomes.
18. The International Society of Heart and Lung Transplantation Annual Meeting and Scientific Sessions. Second INTERMACS Annual Report. Available at http://www.uab.edu/ctsresearch/intermacs/presentations.htm. Accessed March 31, 2010.
19. SG Drakos, et al. 2010 Risk factors predictive of right ventricular failure after left ventricular assist device implantation Am J Cardiol 105 1030 1035 10.1016/j.amjcard.2009.11.026 20346326 This large single-center cohort study of RVF risk in LVAD candidates generated a risk score to predict RVF and survival post LVAD.
20. JA Morgan R John BJ Lee, et al. 2004 Is severe right ventricular failure in left ventricular assist device recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality Ann Thorac Surg 77 859 863 10.1016/j.athoracsur.2003.09.048 14992887
21. NR Sodha RT Clements FW Sellke 2009 Vascular changes after cardiac surgery: role of NOS, COX, kinases, and growth factors Front Biosci 14 689 698 10.2741/3273 1:CAS:528:DC%2BD1MXltFejtrY%3D 19273095
22. DJ Goldstein RB Beauford 2003 Left ventricular assist devices and bleeding: adding insult to injury Ann Thorac Surg 75 6 Suppl S42 S47 10.1016/S0003-4975(03)00478-8 12820734
23. L Santambrogio T Bianchi M Fuardo, et al. 2006 Right ventricular failure after left ventricular assist device insertion: preoperative risk factors Interact Cardiovasc Thorac Surg 5 379 382 10.1510/icvts.2006.128322 17670597
24. JR Fitzpatrick 3rd, et al. 2008 Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support J Heart Lung Transplant 27 1286 1292 10.1016/j.healun.2008.09.006 19059108 This large single-center cohort study of RVF risk in LVAD candidates generated a risk score to predict RVF and survival post LVAD.
25. S Schenk, et al. 2006 Duration of inotropic support after left ventricular assist device implantation: risk factors and impact on outcome J Thorac Cardiovasc Surg 131 447 454 10.1016/j.jtcvs.2005.09.031 16434277
26. ND Patel, et al. 2008 Right heart dysfunction after left ventricular assist device implantation: a comparison of the pulsatile HeartMate I and axial-flow HeartMate II devices Ann Thorac Surg 86 832 840 10.1016/j.athoracsur. 2008.05.016 18721570
27. EV Potapov, et al. 2008 Tricuspid incompetence and geometry of the right ventricle as predictors of right ventricular function after implantation of a left ventricular assist device J Heart Lung Transplant 27 1275 1281 10.1016/j.healun.2008.08.012 19059106 This single-center cohort study examined preoperative RV echocardiographic predictors of post-LVAD RVF. Greater preoperative RV short/long axis ratio and tricuspid regurgitation were associated with more postoperative RVF.
28. S Puwanant, et al. 2008 Tricuspid annular motion as a predictor of severe right ventricular failure after left ventricular assist device implantation J Heart Lung Transplant 27 1102 1107 10.1016/j.healun.2008.07.022 18926401 This single-center cohort study examined preoperative RV echocardiographic predictors of post-LVAD RVF. Preoperative tricuspid annular motion less than 7.5 mm was found to have a 91% specificity for predicting postoperative RVF.
29. MT Maeder, et al. 2009 Changes in right ventricular function during continuous-low left ventricular assist device support J Heart Lung Transplant 28 360 366 10.1016/j.healun.2009.01.007 19332263
30. S Rich, et al. 1998 The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension Chest 114 787 792 10.1378/chest.114.3.787 1:CAS:528:DyaK1cXmsVClsLs%3D 9743167
31. A Costard-Jackle MB Fowler 1992 Influence of preoperative pulmonary artery pressure on mortality after heart-transplantation: testing of potential reversibility of pulmonary hypertension with nitroprusside is useful in defining a high-risk group J Am Coll Cardiol 19 48 54 10.1016/0735-1097(92)90050-W 1:STN:280:DyaK387gsFKjuw%3D%3D 1729345
32. S Nakatani, et al. 1996 Prediction of right ventricular dysfunction after left ventricular assist device implantation Circulation 94 Suppl 216 221
33. M Skhiri, et al. 2010 Evidence-based management of right heart failure: a systematic review of an empiric field Rev Esp Cardiol 63 451 471 10.1016/S1885-5857(10)70094-3 20334811
34. W Mullens, et al. 2009 Usefulness of isosorbide dinitrate and hydralazine as add-on therapy in patients discharged for advanced decompensated heart failure Am J Cardiol 103 1113 1119 10.1016/j.amjcard.2008.12.028 1:CAS:528:DC%2BD1MXktl2jsbY%3D 19361599
35. RJ Tedford, et al. 2008 PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support Circ Heart Fail 1 213 219 10.1161/CIRCHEARTFAILURE.108.796789 1:CAS:528:DC%2BD1cXhtlGmtbjI 19808294 This open-label trial of sildenafil using a historical control in LVAD-supported patients with pulmonary hypertension demonstrated improvements in cardiopulmonary hemodynamics in the sildenafil group.
36. M Argenziano, et al. 1998 Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension Ann Thorac Surg 65 340 345 10.1016/S0003-4975(97)01307-6 1:STN:280:DyaK1c7ktlOlug%3D%3D 9485226
37. CJ De Wet, et al. 2004 Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right heart dysfunction, and refractory hypoxemia after cardiothoracic surgery J Thorac Cardiovasc Surg 127 1058 1067 10.1016/j.jtcvs.2003.11.035 15052203
38. F Wagner, et al. 1997 Nitric oxide inhalation in the treatment of right ventricular dysfunction following left ventricular assist device implantation Circulation 96 Suppl 291 296 1:CAS:528:DyaK2sXnvFajt7k%3D
39. JC Chang, et al. 1997 Hemodynamic effect of inhaled nitric oxide in dilated cardiomyopathy patients on LVAD support ASAIO J 43 5 418 421 10.1097/00002480-199709000-00012
40. PM Mertes, et al. 1995 Impact of nitric oxide inhalation on right ventricular failure after implantation of Novacor left ventricular assist system J Thorac Cardiovasc Surg 109 1251 10.1016/S0022-5223(95)70213-X 1:STN:280:DyaK2M3psFentg%3D%3D 7776693
41. JM Hare, et al. 1997 Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance Circulation 95 2250 2253 1:CAS:528:DyaK2sXjtlOnt7o%3D 9142001
42. TA Khan, et al. 2009 A prospective, randomized, crossover pilot study of inhaled nitric oxide versus inhaled prostacyclin in heart transplant and lung transplant recipients J Thorac Cardiovasc Surg 138 1417 1424 10.1016/j.jtcvs.2009.04.063 1:CAS:528:DC%2BD1MXhsVGlsrbJ 19931670
43. MV Mogollón Jiménez, et al. 2008 Comparison between two drugs on the hemodynamic evaluation of pulmonary hypertension prior to heart transplantation Transplant Proc 40 3009 3011 10.1016/j.transproceed.2008.08.123 19010174
44. A Arcangeli B Rocca G Salvatori, et al. 2010 Heparin versus prostacyclin in continuous hemodiafiltration for acute renal failure: effects on platelet function in the systemic circulation and across the filter Thromb Res 126 24 31 10.1016/j.thromres.2010.01.048 1:CAS:528:DC%2BC3cXnsVaktLY%3D 20185164
45. E Catena F Milazzo 2007 Echocardiography and cardiac assist devices Minerva Cardioangiol 55 247 265 1:STN:280:DC%2BD2s7kt1aqtg%3D%3D 17342042
46. S Chumnavej MJ Wood TE MacGillivary MF Melo 2007 Perioperative echocardiographic examination for ventricular assist device implantation Anesth Analg 105 583 601 10.1213/01.ane.0000278088.22952.82
47. JG Agoustides 2008 Perioperative echocardiographic assessment of left ventricular assist device implantation: additional causes of inflow cannula obstruction Anesth Analg 106 673 674 10.1213/ane.0b013e318160fdde
48. AJ Tector DC Kress FX Downey, et al. 1998 Transition from cardiopulmonary bypass to the HeartMate left ventricular assist device Ann Thorac Surg 65 643 646 10.1016/S0003-4975(97)01353-2 1:STN:280:DyaK1c7os1Ciug%3D%3D 9527188