Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura

Cephalalgia

Volumn 30, Issue 3, 2010, Pages 337-345

  Schytz, H W ^a   Wienecke, T ^a   Olesen, J ^a   Ashina, M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acetylcholine; Cerebral vessels; Human migraine models; Migraine without aura; Nitric oxide; Transcranial doppler

Indexed keywords

CARBACHOL;

ADULT; ARTERY DIAMETER; ARTICLE; BLOOD PRESSURE MEASUREMENT; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEADACHE; HEART RATE; HEAT SENSATION; HUMAN; HUMAN EXPERIMENT; LACRIMATION; MALE; MEAN ARTERIAL PRESSURE; MICTURITION; MIDDLE CEREBRAL ARTERY; MIGRAINE WITHOUT AURA; PAIN ASSESSMENT; RATING SCALE; SALIVATION; SIDE EFFECT; SUPERFICIAL TEMPORAL ARTERY; SWEATING; TREATMENT OUTCOME; VELOCITY;

ACETYLCHOLINE; ADULT; BLOOD PRESSURE; CARBACHOL; CEREBROVASCULAR CIRCULATION; CHOLINERGIC AGONISTS; CROSS-OVER STUDIES; FEMALE; HEADACHE; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MIDDLE CEREBRAL ARTERY; MIGRAINE WITHOUT AURA; NITRIC OXIDE; YOUNG ADULT;

EID: 77956238820     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2009.01929.x     Document Type: Article

References (36)

1. Edvinsson L, Uddman R. Adrenergic, cholinergic and peptidergic nerve fibres in dura mater-involvement in headache? Cephalalgia 1981;1:175-9.
2. Edvinsson L, Gulbenkian S, Barroso CP, Cunha e Sa M, Polak JM, Mortensen A, et al. Innervation of the human middle meningeal artery: immunohistochemistry, ultrastructure, and role of endothelium for vasomotility. Peptides 1998;19:1213-25.
3. Yu JG, Kimura T, Chang XF, Lee TJ. Segregation of VIPergic-nitric oxidergic and cholinergic-nitric oxidergic innervation in porcine middle cerebral arteries. Brain Res 1998;801:78-87.
4. Faraci FM. Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol 1990;259: H1216-21.
5. Faraci FM. Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. Am J Physiol 1991;261: H1038-42.
6. Elhusseiny A, Hamel E. Muscarinic-but not nicotinic-acetylcholine receptors mediate a nitric oxide-dependent dilation in brain cortical arterioles: a possible role for the M5 receptor subtype. J Cereb Blood Flow Metab 2000;20:298-305.
7. Kowacs F, Williamson DJ, Goadsby PJ. Neurogenic vasodilation of dural blood vessels is not mediated by cholinergic transmission in the anaesthetised rat. Eur J Pharmacol 2004;493:133-7.
8. Imaizumi T, Hirooka Y, Masaki H, Harada S, Momohara M, Tagawa T, Takeshita A. Effects of L-arginine on forearm vessels and responses to acetylcholine. Hypertension 1992;20:511-17.
9. Jansen I, Uddman R, Ekman R, Olesen J, Ottosson A, Edvinsson L. Distribution and effects of neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide in human middle meningeal arteries: comparison with cerebral and temporal arteries. Peptides 1992;13:527-36.
10. Rozniecki JJ, Dimitriadou V, Lambracht-Hall M, Pang X, Theoharides TC. Morphological and functional demonstration of rat dura mater mast cell-neuron interactions in vitro and in vivo. Brain Res 1999;849:1-15.
11. Delepine L, Aubineau P. Plasma protein extravasation induced in the rat dura mater by stimulation of the parasympathetic sphenopalatine ganglion. Exp Neurol 1997;147:389-400.
12. Tanelian DL. Cholinergic activation of a population of corneal afferent nerves. Exp Brain Res 1991;86:414-20.
13. Steen KH, Reeh PW. Actions of cholinergic agonists and antagonists on sensory nerve endings in rat skin, in vitro. J Neurophysiol 1993;70:397-405.
14. Armstrong D, Dry RM, Keele CA, Markham JW. Observations on chemical excitants of cutaneous pain in man. J Physiol 1953;120:326-51.
15. Wilson A S H. The effect of the injection of acetylcholine into the brachial artery of normal subjects and patients with myasthenia gravis. Q J Med 1947;16:237-43.
16. Schytz HW, Wienecke T, Oturai PS, Olesen J, Ashina M. The cholinomimetic agent carbachol induces headache in healthy subjects. Cephalalgia 2009;29:258-68.
17. Hamilton CA, Williams R, Pathi V, Berg G, McArthur K, McPhaden AR, et al. Pharmacological characterization of endothelium-dependent relaxation in human radial artery: comparison with internal thoracic artery. Cardiovasc Res 1999;42:214-23.
18. Hardman JG, Limbird LE, Gilman AG. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th edn. New York: McGraw-Hill, 2001.
19. IHS. The International Classification of Headache Disorders, 2nd edn. Cephalalgia 2004;24(Suppl. 1):9-160.
20. Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics. Pain 1989;38:17-24.
21. Iversen L L K C, Thomsen HK, Olesen J. A nitric oxide donor triggers genuine migraine attacks. Eur J Neurol 1994;1:73-80.
22. Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J. CGRP may play a causative role in migraine. Cephalalgia 2002;22:54-61.
23. Olesen J, Bousser MG, Diener HC, Dodick D, First M, Goadsby PJ, et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 2006;26:742-6.
24. Iversen LLAM, Thomsen HK, Olesen J (eds) Middle cerebral artery blood flow velocity increases during experimental pressure pain in the head. Philadelphia, PA: Lippincott-Raven Publishers, 1995.
25. Thomsen LL, Iversen HK. Experimental and biological variation of three-dimensional transcranial Doppler measurements. J Appl Physiol 1993;75:2805-10.
26. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K. Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT. Stroke 1989;20:1733-6.
27. Markwalder TM, Grolimund P, Seiler RW, Roth F, Aaslid R. Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure-a transcranial ultrasound Doppler study. J Cereb Blood Flow Metab 1984;4:368-72.
28. Kruuse C, Thomsen LL, Birk S, Olesen J. Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain 2003;126:241-7.
29. Iversen HK, Nielsen TH, Olesen J, Tfelt-Hansen P. Arterial responses during migraine headache. Lancet 1990;336:837-9.
30. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ 1990;300:230-5.
31. Tvedskov JF, Thomsen LL, Iversen HK, Williams P, Gibson A, Jenkins K, et al. The effect of propranolol on glyceryltrinitrate-induced headache and arterial response. Cephalalgia 2004;24:1076-87.
32. McCulloch AI, Bottrill FE, Randall MD, Hiley CR. Characterization and modulation of EDHF-mediated relaxations in the rat isolated superior mesenteric arterial bed. Br J Pharmacol 1997;120:1431-8.
33. Rahmann A, Wienecke T, Hansen JM, Fahrenkrug J, Olesen J, Ashina M. Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine. Cephalalgia 2008;28:226-36.
34. Schytz HW, Birk S, Wienecke T, Kruuse C, Olesen J, Ashina M. PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 2008.
35. Dong H, Waldron GJ, Cole WC, Triggle CR. Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery. Br J Pharmacol 1998;123:821-32.
36. Wienecke T, Olesen J, Oturai PS, Ashina M. Prostacyclin (epoprostenol) induces headache in healthy subjects. Pain 2008;139:106-16.