Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase i trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 5, 2010, Pages 927-933

  Morgan, Robert J ^a   Synold, Timothy ^a   Mamelak, Adam ^a,b   Lim, Dean ^a   Al Kadhimi, Zaid ^a,c   Twardowski, Przemyslaw ^a   Leong, Lucille ^a   Chow, Warren ^a   Margolin, Kim ^a,d   Shibata, Stephen ^a   Somlo, George ^a   Yen, Yun ^a   Frankel, Paul ^a   Doroshow, James H ^a,e  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Brain tumors; Carboplatin; Chemotherapy; Tamoxifen; Topotecan

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; TAMOXIFEN; TOPOTECAN;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; BREAST CARCINOMA; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; COLON CARCINOMA; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG PENETRATION; DRUG RESPONSE; DRUG WITHDRAWAL; EPENDYMOMA; FEMALE; GLIOBLASTOMA; HUMAN; KARNOFSKY PERFORMANCE STATUS; LUNG EMBOLISM; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALE; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; MEDULLOBLASTOMA; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; THROMBOCYTOPENIA; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CARBOPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SPINAL CORD NEOPLASMS; TAMOXIFEN; TOPOTECAN; YOUNG ADULT;

EID: 77956230255     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1242-z     Document Type: Article

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