The androgen derivative 5α-androstane-3β,17β-diol inhibits tumor necrosis factor α and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta

Atherosclerosis

Volumn 212, Issue 1, 2010, Pages 100-106

  Norata, Giuseppe Danilo ^a,b   Cattaneo, Paola ^a,c   Poletti, Angelo ^a   Catapano, Alberico Luigi ^a,b,c  

^a UNIVERSITY OF MILAN   (Italy)

^b Ospedale Bassini   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

3 Adiol; Atherosclerosis; DHT; Endothelial dysfunction

Indexed keywords

5 ALPHA ANDROSTANE 3BETA,17BETA DIOL; ANDROGEN; BICALUTAMIDE; CD31 ANTIGEN; COMPLEMENTARY DNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FULVESTRANT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ANDROSTANEDIOL; ANTIANDROGEN; ANTIESTROGEN; ANTIINFLAMMATORY AGENT; AUTACOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CASTRATED MALE; CATABOLISM; CELL ACTIVATION; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; EX VIVO STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN MICROARRAY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; C57BL MOUSE; CELL STRAIN U937; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; METHODOLOGY; ORCHIECTOMY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANDROGEN ANTAGONISTS; ANDROSTANE-3,17-DIOL; ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA; ENDOTHELIAL CELLS; ESTROGEN ANTAGONISTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORCHIECTOMY; PROTEIN ARRAY ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 77956225327     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.05.015     Document Type: Article

References (23)

1. Wu F.C., von Eckardstein A. Androgens and coronary artery disease. Endocrinol Rev 2003, 24:183-217.
2. Littleton-Kearney M., Hurn P.D. Testosterone as a modulator of vascular behavior. Biol Res Nurs 2004, 5:276-285.
3. Nathan L., Shi W., Dinh H., et al. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci USA 2001, 98:3589-3593.
4. Malkin C.J., Pugh P.J., Jones R.D., Jones T.H., Channer K.S. Testosterone as a protective factor against atherosclerosis-immunomodulation and influence upon plaque development and stability. J Endocrinol 2003, 178:373-380.
5. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
6. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115-126.
7. Norata G.D., Tibolla G., Seccomandi P.M., Poletti A., Catapano A.L. Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells. J Clin Endocrinol Metab 2006, 91:546-554.
8. Arnal J.F., Scarabin P.Y., Tremollieres F., Laurell H., Gourdy P. Estrogens in vascular biology and disease: where do we stand today?. Curr Opin Lipidol 2007, 18:554-560.
9. Weihua Z., Lathe R., Warner M., Gustafsson J.A. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci USA 2002, 99:13589-13594.
10. Guerini V., Sau D., Scaccianoce E., et al. The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Cancer Res 2005, 65:5445-5453.
11. Norata G.D., Pirillo A., Callegari E., Hamsten A., Catapano A.L., Eriksson P. Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDL. Cardiovasc Res 2003, 59:169-180.
12. Pak T.R., Chung W.C., Hinds L.R., Handa R.J. Estrogen receptor-beta mediates dihydrotestosterone-induced stimulation of the arginine vasopressin promoter in neuronal cells. Endocrinology 2007, 148:3371-3382.
13. Mishra R.G., Stanczyk F.Z., Burry K.A., et al. Metabolite ligands of estrogen receptor-beta reduce primate coronary hyperreactivity. Am J Physiol Heart Circ Physiol 2006, 290:H295-303.
14. Norata G.D., Marchesi P., Pirillo A., et al. Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells. Arterioscler Thromb Vasc Biol 2008, 28:925-931.
15. Norata G.D., Callegari E., Marchesi M., Chiesa G., Eriksson P., Catapano A.L. High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells. Circulation 2005, 111:2805-2811.
16. Pirillo A., Norata G.D., Zanelli T., Catapano A.L. Overexpression of inducible heat shock protein 70 in Cos-1 cells fails to protect from cytotoxicity of oxidized LDLs. Arterioscler Thromb Vasc Biol 2001, 21:348-354.
17. Leon C.G., Locke J.A., Adomat H.H., et al. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate 2010, 70:390-400.
18. Laaksonen D.E., Niskanen L., Punnonen K., et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004, 27:1036-1041.
19. Muller M., van den Beld A.W., Bots M.L., Grobbee D.E., Lamberts S.W., van der Schouw Y.T. Endogenous sex hormones and progression of carotid atherosclerosis in elderly men. Circulation 2004, 109:2074-2079.
20. Yeap B.B., Hyde Z., Almeida O.P., et al. Lower testosterone levels predict incident stroke and transient ischemic attack in older men. J Clin Endocrinol Metab 2009, 161:591-598.
21. Jones T.H., Saad F. The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process. Atherosclerosis 2009, 207:318-327.
22. Traish A.M., Saad F., Feeley R.J., Guay A. The dark side of testosterone deficiency: III. Cardiovascular disease. J Androl 2009, 30:477-494.
23. Hatakeyama H., Nishizawa M., Nakagawa A., Nakano S., Kigoshi T., Uchida K. Testosterone inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. FEBS Lett 2002, 530:129-132.