Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution (Review)

Experimental and Therapeutic Medicine

Volumn 1, Issue 2, 2010, Pages 265-269

  Vermorken, A J M ^a   Zhu, J ^a   van de Ven, W J M ^a   Cui, Y ^c   Fryns, J P ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c NORTHWEST UNIVERSITY   (China)

Author keywords

Common variable immunodeficiency; Curcumin; Dendritic cells; Information society; Monoclonal gammopathy of undetermined significance

Indexed keywords

CURCUMIN; FLUOROURACIL; TRANSFER FACTOR;

ADULT; BRONCHITIS; CASE REPORT; COMMON VARIABLE IMMUNODEFICIENCY; CONSTIPATION; COUGHING; DENDRITIC CELL; DIARRHEA; DISEASE COURSE; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPROMISED PATIENT; IRRITABLE COLON; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; PATHOPHYSIOLOGY; PATIENT MONITORING; REVIEW; VERRUCA PLANTARIS; WHEEZING;

EID: 77956222421     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm_00000041     Document Type: Review

References (31)

1. Hatcher H, Planalp R, Cho J, Torti FM and Torti SV: Curcumin: from ancient medicine to current clinical trials. Review. Cell Mol Life Sci 65: 1631-1652, 2008.
2. Golombick T and Diamond TH: The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia. Biologics 2: 161-163, 2008.
3. Golombick T, Diamond TH, Badmaev V, Manoharan A and Ramakrishna R: The potential role of curcumin in patients with monoclonal gammopathy of undefined significance - its effect on paraproteinemia and the urinary N-telopeptide of type Icollagen bone turnover marker. Clin Cancer Res 15: 5917-5922, 2009.
4. Kyle RA: Monoclonal gammopathy of undetermined significance. Review. Blood Rev 8: 135-141, 1994.
5. Rosiñol L, Cibeira MT, Montoto S, Rozman M, Esteve J, Filella X and Bladé J: Monoclonal gammopathy of undetermined significance: predictors of malignant transformation and recognition of an evolving type characterized by a progressive increase in M protein size. Mayo Clin Proc 82: 428-434, 2007.
6. Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Offord JR, Dispenzieri A, Katzmann J Aand Melton LJ III: Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 354: 1362-1369, 2006.
7. Kyle RA, Rajkumar SV, Therneau TM, Larson DR, Plevak MF and Melton LJ III: Prognostic factors and predictors of outcome of immunoglobulin Mmonoclonal gammopathy of undetermined significance. Clin Lymphoma 5: 257-260, 2005.
8. Gregersen H, Ibsen J, Mellemkjoer L, Dahlerup J, Olsen J and Sørensen HT: Mortality and causes of death in patients with monoclonal gammopathy of undetermined significance. Br J Haematol 112: 353-357, 2001.
9. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC and Hsieh CY: Phase Iclinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21: 2895-2900, 2001.
10. Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ and Steward WP: Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 10: 6847-6854, 2004.
11. Rajkumar SV: Prevention of progression in monoclonal gammopathy of undetermined significance. Clin Cancer Res 15: 5606-5608, 2009.
12. Holt PR, Katz S and Kirshoff R: Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 50: 2191-2193, 2005.
13. Conteas CN, Panossian AM, Tran TT and Singh HM: Treatment of HIV-associated diarrhea with curcumin. Dig Dis Sci 54: 2188-2191, 2009.
14. Ammon HP and Wahl MA: Pharmacology of Curcuma longa. Planta Med 57: 1-7, 1991.
15. Lacombe C, Aucouturier P and Preud'homme JL: Selective IgG1 deficiency. Clin Immunol Immunopathol 84: 194-201, 1997.
16. Bierwirth J, Ulbricht KU, Schmidt RE and Witte T: Association of common variable immunodeficiency with vitamin B6 deficiency. Eur J Clin Nutr 62: 332-335, 2008.
17. Van der Steen P, van de Kerkhof P, der Kinderen D, van Vlijmen I and Happle R: Clinical and immunohistochemical responses of plantar warts to topical immunotherapy with diphenylcyclopropenone. J Dermatol 18: 330-333, 1991.
18. Lynn J, Knight AK, Kamoun M and Levinson AI: A55-year-old man with hypogammaglobulinemia, lymphopenia and unrelenting cutaneous warts. J Allergy Clin Immunol 114: 409-414, 2004.
19. Varalakshmi CH, Ali AM, Pardhasaradhi BV, Srivastava RM, Singh S and Khar A: Immunomodulatory effects of curcumin: in vivo. Int Immunopharmacol 8: 688-700, 2008.
20. Gill MA, Palucka AK, Barton T, Ghaffar F, Jafri H, Banchereau J and Ramilo O: Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections. J Infect Dis 191: 1105-1115, 2005.
21. Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Galicier L, Lepelletier Y, Webster D, Lévy Y, Eibl MM, Oksenhendler E, Hermine O and Kaveri SV: Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood 104: 2441-2443, 2004.
22. Scott-Taylor TH, Green MR, Raeiszadeh M, Workman S and Webster AD: Defective maturation of dendritic cells in common variable immunodeficiency. Clin Exp Immunol 145: 420-427, 2006.
23. Cunningham-Rundles C and Radigan L: Deficient IL-12 and dendritic cell function in common variable immune deficiency. Clin Immunol 115: 147-153, 2005.
24. Ravanbakhsh M, Sarafnejad A, Aghamohammadi A, Kardar GA, Asgarian Omran H, Atarod L, Rezaei N, Shahrestani T, Hosseini M and Moin M: CD40 ligand expression on stimulated T-helper lymphocytes in patients with common variable immunodeficiency. Iran J Allergy Asthma Immunol 6: 129-135, 2007.
25. Yong PF, Workman S, Wahid F, Exley A, Webster AD and Ibrahim MA: Selective deficits in blood dendritic cell subsets in common variable immunodeficiency and X-linked agammaglo-bulinaemia but not specific polysaccharide antibody deficiency. Clin Immunol 127: 34-42, 2008.
26. Kim GY, Kim KH, Lee SH, Yoon MS, Lee HJ, Moon DO, Lee CM, Ahn SC, Park YC and Park YM: Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 174: 8116-8124, 2005.
27. Shirley SA, Montpetit AJ, Lockey RF and Mohapatra SS: Curcumin prevents human dendritic cell response to immune stimulants. Biochem Biophys Res Commun 374: 431-436, 2008.
28. Martín-Ayuso M, Almeida J, Pérez-Andrés M, Cuello R, Galende J, González-Fraile MI, Martín-Nuñez G, Ortega F, Rodríguez MJ, San Miguel JF and Orfao A: Peripheral blood dendritic cell subsets from patients with monoclonal gammopathies show an abnormal distribution and are functionally impaired. Oncologist 13: 82-92, 2008.
29. McMaster ML, Kristinsson SY, Turesson I, Björkholm M and Landgren O: Novel aspects pertaining to the relationship of Waldenström's macroglobulinemia, IgMmonoclonal gammopathy of undetermined significance, polyclonal gammopathy and hypoglobulinemia. Clin Lymphoma Myeloma 9: 19-22, 2009.
30. Gregersen H, Mellemkjaer L, Ibsen JS, Dahlerup JF, Thomassen L and Sørensen HT: The impact of M-component type and immunoglobulin concentration on the risk of malignant transformation in patients with monoclonal gammopathy of undetermined significance. Haematologica 86: 1172-1179, 2001.
31. Lee SW, Nah SS, Byon JS, Ko HJ, Park SH, Lee SJ, Shin WY and Jin DK: Transient complete atrioventricular block associated with curcumin intake. Int J Cardiol: Nov. 3, 2009 (Epub ahead of print).