Novel phosphatase PHLPP-1 regulates mitochondrial AKT activity and cardiac cell survival

Circulation Research

Volumn 107, Issue 4, 2010, Pages 448-450

  Aviv, Yaron ^a   Kirshenbaum, Lorrie A ^a,b  

^a ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Akt; cell survival; mitochondria; PHLPP 1

Indexed keywords

PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

CELL SURVIVAL; EDITORIAL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; HEART MITOCHONDRION; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; ONCOGENE PROTEIN V-AKT; PHOSPHOPROTEIN PHOSPHATASES;

EID: 77956218759     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.225896     Document Type: Editorial

References (15)

1. Walsh K. Akt signaling and growth of the heart. Circulation. 2006;113: 2032-2034.
2. Matsui T, Nagoshi T, Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle. 2003;2:220-223.
3. Matsui T, Li L, del M, Fukui Y, Franke TF, Hajjar RJ, Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 1999;100:2373-2379.
4. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem. 2002;277:37670-37677.
5. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002;110:737-749.
6. Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 2004;37:449-471.
7. Haq S, Choukroun G, Kang ZB, Ranu H, Matsui T, Rosenzweig A, Molkentin JD, Alessandrini A, Woodgett J, Hajjar R, Michael A, Force T. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol. 2000;151:117-130.
8. Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev. 1998;12:502-513.
9. Sopjani M, Kunert A, Czarkowski K, Klaus F, Laufer J, Foller M, Lang F. Regulation of the Ca(2 +) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve. J Membr Biol. 2010;233:35-41.
10. Asnaghi L, Bruno P, Priulla M, Nicolin A. mTOR: a protein kinase switching between life and death. Pharmacol Res. 2004;50:545-549.
11. Shaw J, Kirshenbaum LA. Prime time for JNK-mediated Akt reactivation in hypoxia-reoxygenation. Circ Res. 2006;98:7-9.
12. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Heller Brown J. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010;107:476-484.
13. Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008;283:6300-6311.
14. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg GK, Zhao H. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J Neurochem. 2008;105:943-955.
15. Force T, Woodgett JR. Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem. 2009;284:9643-9647.