Molecular imaging of cardiac sympathetic innervation by 11C-mHED and PET: From man to mouse?

Journal of Nuclear Medicine

Volumn 51, Issue 8, 2010, Pages 1269-1276

  Law, Marilyn P ^a   Schäfers, Klaus ^a   Kopka, Klaus ^a   Wagner, Stefan ^a   Schober, Otmar ^a   Schäfers, Michael ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

11C meta hydroxyephedrine; Cardiac imaging; Norepinephrine reuptake; Small animal PET; Sympathetic innervation

Indexed keywords

(N METHYL) 3 HYDROXYEPHEDRINE C 11; FLUORODEOXYGLUCOSE F 18; METARAMINOL; NORADRENALIN; RADIOISOTOPE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; 3 HYDROXYEPHEDRINE; 3-HYDROXYEPHEDRINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DIAGNOSTIC AGENT; DRUG DERIVATIVE; EPHEDRINE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; ADRENERGIC SYSTEM; ALGORITHM; ANIMAL; BINDING COMPETITION; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; HEART; HEART MUSCLE; HUMAN; IMAGE PROCESSING; INNERVATION; METABOLISM; SCINTISCANNING; SPECIES DIFFERENCE; STATISTICAL ANALYSIS; SYNTHESIS;

ADRENERGIC ALPHA-AGONISTS; ALGORITHMS; ANIMALS; AREA UNDER CURVE; BINDING, COMPETITIVE; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPHEDRINE; HEART; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; METARAMINOL; MICE; MICE, INBRED C57BL; MYOCARDIUM; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SPECIES SPECIFICITY; SYMPATHETIC NERVOUS SYSTEM;

EID: 77956213244     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.074997     Document Type: Article

References (20)

1. Brodde OE, Leinewever K. Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur J Pharmacol. 2004;500:167-176.
2. Lautamäki R, Tipre D, Bengel FM. Cardiac sympathetic neuronal imaging using PET. Eur J Nucl Med Mol Imaging. 2007;34:S74-S85.
3. Schäfers M, Dutka D, Rhodes CG, et al. Myocardial presynaptic and postsynaptic autonomic dysfunction in hypertrophic cardiomyopathy. Circ Res. 1998;82:57-62. (Pubitemid 28074019)
4. Schäfers M, Lerch H, Wichter T, et al. Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia. J Am Coll Cardiol. 1998;32:181-186.
5. Wichter T, Schäfers M, Rhodes CG, et al. Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy: quantitative assessment of presynaptic norepinephrine reuptake and postsynaptic b-adrenergic receptor density with positron emission tomography. Circulation. 2000;101:1552-1558.
6. Kies P, Wichter T, Schäfers M, et al. Abnormal myocardial presynaptic norepinephrine recycling in patients with the Brugada syndrome. Circulation. 2004;110:3017-3022.
7. Schelbert HR, Inubushi M, Ross RS. PET imaging in small animals. J Nucl Cardiol. 2003;10:513-520.
8. Tipre DN, Fox JJ, Holt DP, et al. In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. J Nucl Med. 2008;49:1189-1195.
9. 1- adrenoceptor selective radioligands suitable for PET? Eur J Nucl Med Mol Imaging. 2008;35:174-185.
10. Hume SP, Gunn RN, Jones T. Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals. Eur J Nucl Med. 1988;25:173-176.
11. Jeavons AP, Chandler RA, Dettmar CAR. A 3D HIDAC-PET camera with submillimetre resolution for imaging small animals. IEEE Trans Nucl Sci. 1999;46:468-473. (Pubitemid 30504999)
12. Missimer J, Madi Z, Honer M, Keller C, Schubiger A, Ametamey SM. Performance evaluation of the 16-module quad-HIDAC small animal PET camera. Phys Med Biol. 2004;49:2069-2081.
13. Schäfers KP, Reader AJ, Kriens M, Knoess C, Schober O, Schäfers M. Performance Evaluation of the 32-module quadHIDAC small animal PET scanner. J Nucl Med. 2005;46:996-1004.
14. Law MP. Demonstration of the suitability of CGP 12177 for in vivo studies of β-adrenoceptors. Br J Pharmacol. 1993;109:1101-1109.
15. 11C]-m-hydroxyephedrine in the rat. Nucl Med Biol. 1997;24:417-424.
16. Rosenspire KC, Haka MS, vanDort ME, et al. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyepehdrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990;31:1328-1334.
17. Reader AJ, Ally S, Bakatselos F, et al. One-pass list-mode EM algorithm for high resolution 3D PET image reconstruction into large arrays. IEEE Trans Nucl Sci. 2002;49:693-699.
18. 11C] hydroxyephedrine and positron emission tomography. Circulation. 2000;101:516-523.
19. Malizia AL, Melicher JK, Rhodes CG, et al. Desipramine binding to noradrenaline reuptake sites in cardiac sympathetic neurones in man in vivo. Eur J Pharmacol. 2000;391:263-267.
20. 11C-meta-hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue. J Nucl Med. 2007;48:1733-1740.