Pro-healing potential of hemin: An inducer of heme oxygenase-1

European Journal of Pharmacology

Volumn 645, Issue 1-3, 2010, Pages 165-170

  Ahanger, Azad A ^a   Prawez, Shahid ^a   Leo, Marie Dennis Marcus ^a   Kathirvel, Kandaswamy ^a   Kumar, Dinesh ^a   Tandan, Surendra K ^a   Malik, Jitendra K ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Heme oxygenase; Hemin; Wound healing

Indexed keywords

BETA ACTIN; GLUCOSAMINE; HEME OXYGENASE 1; HEMIN; HYDROXYPROLINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; MESSENGER RNA; POVIDONE IODINE; TUMOR NECROSIS FACTOR ALPHA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY FLOW; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; EPITHELIZATION; GRANULATION TISSUE; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION; WOUND CONTRACTION; WOUND HEALING;

ANIMALS; CELL PROLIFERATION; ENZYME INDUCTION; HEME OXYGENASE-1; HEMIN; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-10; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RNA, MESSENGER; SKIN; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; WOUND HEALING;

EID: 77956188323     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.048     Document Type: Article

References (35)

1. Abraham N.G., Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol. Rev. 2008, 60:79-127.
2. Applegate L.A., Noel A., Vile G.E., Frenk E., Tyrell R.M. Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: implications for protection against oxidant stress. Photochem. Photobiol. 1995, 61:285-291.
3. Dennery P.A., Wong H.E., Sridhar K.J., Rodgers P.A., Sim J.E., Spitz D. Differences in basal and hyperoxia-associated HO expression in oxidant resistant hamster fibroblasts. Am. J. Physiol. 1996, 271:L672-L679.
4. Dennery P.K., Sridhar C., Lee H., Wong H., Shokoohi V., Rodgers P., Spitz D. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. J. Biol. Chem. 1997, 272:14937-14942.
5. Dennery P.A., Spitz D.R., Yang G., Tatarov A., Lee C.S., Shegog M.L., Poss K.D. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. J. Clin. Invest. 1998, 101:1001-1011.
6. Deramaudt B.M., Braunstein S., Remy P. Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis. J. Cell. Biochem. 1998, 68:121-127.
7. Dong Z.Y., Lavrovsky M.A., Venkatachalam M.A., Roy A.K. Heme oxygenase-1 in tissue pathology: the Yin and Yang. Am. J. Pathol. 2000, 156:1485-1488.
8. Ferris C.D., Jaffrey S.R., Sawa A., Takashashi M., Brady S.D., Barrow R.K., Tysoe S.A., Wolosker H., Baranano D.E., Dore S. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat. Cell Biol. 1999, 1:152-157.
9. Fouad A.A., Qureshi H.A., Al-Sultan A.I., Yacoubi M.T., Ali A.A. Protective effect of hemin against cadmium-induced testicular damage in rats. Toxicology 2008, 257:153-160. 29.
10. Grochot-Przeczek A., Lach R., Mis J., Skrzypek K., Gozdecka M., Sroczynska P., Dubiel M., Rutkowski A., Kozakowska M., Zagorska A., Walczynski J., Was H., Kotlinowski J., Drukala J., Kurowski K., Kieda C., Herault Y., Dulak J., Jozkowicz A. Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS ONE 2009, 4:e5803.
11. Keshavan P., Deem T.L., Schwemberger S.J., Babcock G.F., Cook-Mills J.M., Zucker S.D. Unconjugated bilirubin inhibits VCAM-1 mediated transendothelial leukocyte migration. J. Immunol. 2005, 174:3709-3718.
12. Kim H.P., Ryter S.W., Choi A.M. CO as cellular signalling molecule. Annu. Rev. Pharmacol. Toxicol. 2006, 46:411-449.
13. Kirino M., Kirino Y., Takeno M., Nagashima Y., Takahashi K., Kobayashi M., Murakami S., Hirasawa T., Ueda A., Aihara M., Ikezawa Z., Ishigatsubo Y. Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J. Allergy Clin. Immunol. 2008, 122:290-297.
14. Laniado-Schwartzman M., Abraham N.G., Sacerdoti D., Escalante B., McGiff J.C. Effect of acute and chronic treatment of tin on blood pressure in spontaneously hypertensive rats. Tohoku J. Exp. Med. 1992, 166:85-91.
15. Lee P.J., Alam J., Wiegand G.W., Choi A.M. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Nat. Acad. Sci. U.S.A. 1996, 93:10393-10398.
16. Livak K.J., Schmitten T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DeltaDelta(CT)). Methods 2001, 25:402-408.
17. Morse D., Pischke S.E., Zhou Z., Dvis R.J., Flavell R.A., Loop T., Otterbein S.L., Otterbein L.E. Suppression of inflammatory cytokine production by carbon monoxide involves JNK pathway and AP-1. J. Biol. Chem. 2003, 278:36993-36998.
18. Moulin V., Auger F.A., Garel D., German L. Role of wound healing myofiroblasts on reepithelialisation of human skin. Burns 2000, 26:3-12.
19. Otterbein L.E., Bach F.H., Alam J., Soares M., Tao Lu H., Wysk M., Davis R.J., Flavell R.A., Choi A.M. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med. 2000, 6:422-428.
20. Petrache I., Otterbein L.E., Alam J., Wiegand G.W., Choi A.M. Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 278:L312-L319.
21. Poss K.D., Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc. Nat. Acad. Sci. U.S.A. 1997, 94:10925-10930.
22. Rondle C.J.M., Morgan W.I.J. The determination of glucosamine and galactosamine. Biochem. J. 1955, 61:586-589.
23. Ryter S., Otterbein L. Carbon monoxide in biology and medicine. Bioessays 2004, 26:270-280.
24. Ryter S., Alam J., Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic application. Physiol. Rev. 2006, 86:583-650.
25. Sacerdoti D., Escalante B., Abraham N.G., McGiff J.C., Levere R.D., Schwartzman M.L. Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science 1989, 243:388-390.
26. Sessa W.C., Abraham N.G., Escalante B., Schwartzman M.L. Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats. J. Hypertens. 1989, 7:37-42.
27. Singer A.J., Clark R.A.F. Cutaneous wound healing. N Engl J. Med. 1999, 341:738-746.
28. Stocker R., Yamamto Y., McDonagh A.F., Glazer A.N., Amers B.N. Bilirubin is an antioxidant of possible physiological importance. Science 1987, 235:1043-1046.
29. Turkseven S., Kruger A., Mingone C.J., Kaminiski P., Inaba M., Rodella L.F., Ikehara S., Wolin M.S., Abraham N.G. Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes. Am. J. Physiol. 2005, 289:H701-H707.
30. Vile G.F., Basu-Modak S.C., Waltner C., Tyrell R.M. Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Nat. Acad. Sci. U.S.A. 1994, 91:2607-2610.
31. Werner S., Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 2003, 83:835-870.
32. Woessner J.F. The determination of hydroxyproline in tissue and protein sample containing small proportions of this imino acid. Arch. Biochem. Biophys. 1961, 93:440-447.
33. Yamashita K., McDaid J., Ollinger R., Tsui T.Y., Berberat P.O., Usheva A., Csizmadia E., Smith R.N., Bach F.H. Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts. FASEB J. 2004, 18:765-767.
34. Yoneya R., Ozasa H., Nagashima Y., Koike Y., Teraoka H., Hagiwara K., Horikawa S. Hemin pretreatment ameliorates aspects of the nephropathy induced by mercuric chloride in the rat. Toxicol. Lett. 2000, 116:223-229.
35. Zhong W., Xia Z., Hinrichs D., Rosenbaum J.T., Wegmann K.W., Meyrowitz J., Zhang Z. Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis. J. Pediatr. Gastroenterol. Nutr. 2010, 50:132-139.