Breast cancer cell CD200 expression regulates immune response to EMT6 tumor cells in mice

Breast Cancer Research and Treatment

Volumn 123, Issue 2, 2010, Pages 405-415

  Gorczynski, Reginald M ^a   Chen, Zhiqi ^a   Diao, Jun ^a   Khatri, Ismat ^a   Wong, Karrie ^a   Yu, Kai ^a   Behnke, Julia ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Breast cancer; CD200 transgene; Immunotherapy; Treg

Indexed keywords

CD200 ANTIBODY; CD200 ANTIGEN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL COMPOSITION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HOST CELL; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE CELL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSPLANTABLE SOLID TUMORS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; CLONE CELLS; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; IMMUNOCOMPETENCE; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; LYMPH NODES; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; TIME FACTORS; TUMOR BURDEN;

EID: 77956187111     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0667-8     Document Type: Article

References (42)

1. M Kato FJ Slack 2008 Micro RNAS: small molecules with big roles-C. elegans to human cancer Biol Cell 100 71 81 10.1042/BC20070078 1:CAS:528:DC%2BD1cXosFarsg%3D%3D 18199046
2. C Dierks J Grbic K Zirlik R Beigi NP Englund GR Guo H Veelken M Engelhardt R Mertelsmann JF Kelleher P Schultz M Warmuth 2007 Essential role of stromally induced hedgehog signaling in B-cell malignancies Nat Med 13 944 951 10.1038/nm1614 1:CAS:528:DC%2BD2sXos1Cjsb0%3D 17632527
3. HR Salih SG Kosowski VF Haluska GC Starling DT Loo F Lee AA Aruffo PA Trail PA Kiener 2000 Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells J Immunol 165 2903 2910 1:CAS:528:DC%2BD3cXmtFOqsrs%3D 10946324
4. JM Ilvesaro MA Merrell L Li S Wakchoure D Graves S Brooks E Rahko A JukkolaVuorinen KS Vuopala KW Harris KS Selander 2008 Toll-like receptor 9 mediates CpG oligonucleotide-induced cellular invasion Mol Cancer Res 6 1534 1543 10.1158/1541-7786.MCR-07-2005 1:CAS:528:DC%2BD1cXht1Cmsb7P 18922969
5. J Moreaux D Hose T Reme E Jourdan M Hundemer E Legouffe P Moine P Bourin M Moos J Corre T Möhler J De Vos JF Rossi H Goldschmidt B Klein 2006 CD200 is a new prognostic factor in multiple myeloma Blood 108 4194 4197 10.1182/blood-2006-06-029355 1:CAS:528:DC%2BD28XhtlWqsrjE 16946299
6. KB Petermann GI Rozenberg D Zedek P Groben K McKinnon C Buehler WY Kim JM Shields S Penland JE Bear NE Thomas JS Serody NE Sharpless 2007 CD200 is induced by ERK and is a potential therapeutic target in melanoma J Clin Invest 117 3922 3929 1:CAS:528:DC%2BD2sXhsValsL%2FF 18008004
7. J Moreaux JL Veyrune T Reme J De Vos B Klein 2008 CD200: a putative therapeutic target in cancer Biochem Biophys Res Commun 366 117 122 10.1016/j.bbrc.2007.11.103 1:CAS:528:DC%2BD2sXhsVOksbfL 18060862
8. A Siva H Xin F Qin D Oltean KS Bowdish A Kretz-Rommel 2008 Immune modulation by melanoma and ovarian tumor cells through expression of the immunosuppressive molecule CD200 Cancer Immunol Immunother 57 987 996 10.1007/s00262-007-0429-6 1:CAS:528:DC%2BD1cXltFeqtLs%3D 18060403
9. JR McWhirter A Kretz-Rommel A Saven T Maruyama KN Potter CI Mockridge EP Ravey FH Qin KS Bowdish 2006 Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation Proc Nat Acad Sci USA 103 1041 1046 10.1073/pnas.0510081103 1:CAS:528:DC%2BD28XhsVKgtbo%3D 16418292
10. A Tonks 2007 CD200 as a prognostic factor in acute myeloid leukemia Leukemia 21 566 568 10.1038/sj.leu.2404559 1:CAS:528:DC%2BD2sXhvFWkt74%3D 17252007
11. RM Hoek SR Ruuls CA Murphy GJ Wright R Goddard SM Zurawski B Blom ME Homola WJ Streit MH Brown AN Barclay JD Sedgwick 2000 Down-regulation of the macrophage lineage through interaction with OX2 (CD200) Science 290 1768 1771 10.1126/science.290.5497.1768 1:CAS:528:DC%2BD3cXovVOhuro%3D 11099416
12. A Kretz-Rommel FH Qin N Dakappagari EP Ravey J McWhirter D Oltean S Frederickson T Maruyama MA Wild MJ Nolan DY Wu J Springhorn KS Bowdish 2007 CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy J Immunol 178 5595 5605 1:CAS:528:DC%2BD2sXktlWiu74%3D 17442942
13. BT Kawasaki T Mistree EM Hurt M Kalathur WL Farrar 2007 Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells Biochem Biophys Res Commun 364 778 782 10.1016/j.bbrc.2007.10.067 1:CAS:528: DC%2BD2sXhtlaltr3P 17964286
14. SA Rosenberg 2004 Cancer immunotherapy: moving beyond current vaccines Nat Med 10 909 915 10.1038/nm1100 1:CAS:528:DC%2BD2cXntFSktL0%3D 15340416
15. RM Gorczynski Z Chen W He I Khatri Y Sun K Yu I Boudakov 2009 Expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts J Immunol 183 1560 1568 10.4049/jimmunol.0900200 1:CAS:528:DC%2BD1MXoslCkur8%3D 19592654
16. RM Gorczynski MS Cattral ZG Chen JA Hu J Lei WP Min G Yu J Ni 1999 An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival J Immunol 163 1654 1660 1:CAS:528:DyaK1MXkslOgsbc%3D 10415071
17. CG Jakobsen N Rasmussen A-V Laenkholm HJ Ditzel 2007 Phage display-derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78 Cancer Res 67 9507 9517 10.1158/0008-5472.CAN-06-4686 1:CAS:528:DC%2BD2sXhtFSnurvE 17909061
18. PD Andrews 2003 Aurora kinases: shining lights on the therapeutic horizon? Oncogene 24 5005 5015 10.1038/sj.onc.1208752
19. Wong K, Spaner DE, Gorczynski RM (2008) Lymphoma cell surface expression of CD200 modulates anti-tumor immunity (abstract). AAI, San Diego
20. L Wu IF Tannock 2003 Repopulation in murine breast tumors during and after sequential treatments with cyclophosphamide and 5-fluorouracil Cancer Res 63 2134 2138 1:CAS:528:DC%2BD3sXjtlGmtr8%3D 12727830
21. J Diao JA Smythe C Smyth PB Rowe IE Alexander 1999 Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro Gene Ther 6 845 853 10.1038/sj.gt.3300899 1:CAS:528:DyaK1MXjtVKgt7Y%3D 10505110
22. CP Blobel 2005 ADAMS: key players in EGFR-signaling, development and disease Nat Rev Mol Cell Biol 6 32 43 10.1038/nrm1548 1:CAS:528:DC%2BD2MXlvVWn 15688065
23. RM Gorczynski Z Chen J Hu Y Kai J Lei 2001 Evidence of a role for CD200 in regulation of immune rejection of leukaemic tumour cells in C57BL/6 mice Clin Exp Immunol 126 220 229 10.1046/j.1365-2249.2001.01689.x 1:CAS:528: DC%2BD3MXotlCqtbs%3D 11703364
24. A Kretz-Rommel F Qin N Dakappagari R Cofiell SJ Faas KS Bowdish 2008 Blockade of CD200 in the presence or absence of antibody effector function: implications for anti-CD200 therapy J Immunol 180 699 705 1:CAS:528: DC%2BD1cXhsVyjtw%3D%3D 18178807
25. O Kawai G Ishii K Kubota Y Murata Y Naito T Mizuno K Aokage N Saijo Y Nishiwaki A Gemma S Kudo A Ochiai 2008 Predominant infiltration of macrophages and CD8(+) T cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer Cancer 113 1387 1395 10.1002/cncr.23712 1:CAS:528:DC%2BD1cXhtFyls7rL 18671239
26. RM Gorczynski 2005 CD200 and its receptors as targets for immunoregulation Curr Opin Invest Drugs 6 483 488 1:CAS:528:DC%2BD2MXksF2jurs%3D
27. A Sica P Allavena A Mantovani 2008 Cancer related inflammation: the macrophage connection Cancer Lett 267 204 215 10.1016/j.canlet.2008.03.028 1:CAS:528:DC%2BD1cXovF2hsLk%3D 18448242
28. J Baumgartner C Wilson B Palmer D Richter A Banerjee M McCarter 2007 Melanoma induces immunosuppression by up-regulating FOXP3(+) regulatory T cells J Surg Res 141 72 77 10.1016/j.jss.2007.03.053 1:CAS:528:DC%2BD2sXmsFCrt7c%3D 17574040
29. SP Hilchey A De LM Rimsza RB Bankert SH Bernstein 2007 Follicular lymphoma intratumoral CD4(+)CD25(+)GITR(+) regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8(+)CD25(-) and CD4(+)CD25(-) T cells J Immunol 178 4051 4061 1:CAS:528:DC%2BD2sXjt1WltL8%3D 17371959
30. S Sakaguchi 2004 Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 531 562 10.1146/annurev.immunol.21.120601.141122 1:CAS:528: DC%2BD2cXktlOgsLo%3D 15032588
31. H Groux 2003 Type 1 T-regulatory cells: their role in the control of immune responses Transplantation 75 8S 12S 10.1097/01.TP.0000067944.90241.BD 1:CAS:528:DC%2BD3sXmtFWlu7c%3D 12819483
32. H Jiang L Chess 2004 An integrated view of suppressor T cell subsets in immunoregulation J Clin Invest 114 1198 1208 1:CAS:528:DC%2BD2cXpsFCgsb8%3D 15520848
33. JA Kapp LM Kapp KC McKenna 2004 Gamma delta T cells play an essential role in several forms of tolerance Immunol Res 29 93 102 10.1385/IR:29:1-3:093 1:CAS:528:DC%2BD2cXlsFGitb0%3D 15181273
34. KJ Young L Zhang 2002 The nature and mechanisms of DN regulatory T-cell mediated suppression Hum Immunol 63 926 934 10.1016/S0198-8859(02)00446-9 1:CAS:528:DC%2BD38XnsVSitbg%3D 12368045
35. RM Gorczynski Z Chen Y Kai S Wong L Lee 2004 Induction of tolerance-inducing antigen-presenting cells in bone marrow cultures in vitro using monoclonal antibodies to CD200R Transplantation 77 1138 1144 10.1097/01.TP.0000121773.18476.1C 1:CAS:528:DC%2BD2cXksFOktbg%3D 15114074
36. RM Gorczynski L Lee I Boudakov 2005 Augmented induction of CD4(+)CD25(+) Treg using monoclonal antibodies to CD200R Transplantation 79 488 491 10.1097/01.TP.0000152118.51622.F9 1:CAS:528:DC%2BD2MXhsF2lt7g%3D 15729177
37. S Nagaraj DI Gabrilovich 2008 Tumor escape mechanism governed by myeloid-derived suppressor cells Cancer Res 68 2561 2563 10.1158/0008-5472.CAN- 07-6229 1:CAS:528:DC%2BD1cXks1Git7s%3D 18413722
38. B Cipriani A Fridman C Bendtsen S Dharmapuri C Mennuni I Pak G Mesiti G Forni P Monaci A Bagchi G Ciliberto N LaMonica E Scarselli 2008 Therapeutic vaccination halts disease progression in BALB-neuT mice: the amplitude of elicited immune response is predictive of vaccine efficacy Hum Gene Ther 19 670 680 10.1089/hum.2007.127 1:CAS:528:DC%2BD1cXovFWmsbs%3D 18533895
39. CM Diaz-Montero ML Salem MI Nishimura E Garrett-Mayer DJ Cole AJ Montero 2009 Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy Cancer Immunol Immunother 58 49 59 10.1007/s00262-008-0523-4 1:CAS:528:DC%2BD1cXht1yqs7bN 18446337
40. JB Zhou H Zhang PH Gu JN Bai JB Margolick Y Zhang 2008 NF-kappa B pathway inhibitors preferentially inhibit breast cancer stem-like cells Breast Cancer Res Treat 111 419 427 10.1007/s10549-007-9798-y 1:CAS:528:DC%2BD1cXhtV2js7bI 17965935
41. ET Liu 2008 Functional genomics of cancer Curr Opin Genet Develop 18 251 256 10.1016/j.gde.2008.07.014 1:CAS:528:DC%2BD1cXhtFOltL7I
42. P Kuvaja A Talvensaari-Mattila T Turpeenniemi-Hujanen 2008 High preoperative plasma TIMP-1 is prognostic for early relapse in primary breast carcinoma Int J Cancer 123 846 851 10.1002/ijc.23531 1:CAS:528: DC%2BD1cXovFWmurw%3D 18506691