Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3

Journal of Ethnopharmacology

Volumn 105, Issue 3, 2006, Pages 409-414

  Sato, Yuji ^a   Akao, Teruaki ^a   He, Ju Xiu ^a   Nojima, Hiroshi ^a   Kuraishi, Yasushi ^a   Morota, Takashi ^b   Asano, Takayuki ^b   Tani, Tadato ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b TSUMURA AND CO   (Japan)

Author keywords

Antispasmodic; cAMP; Glycycoumarin; Glycyrrhiza ularensis; Glycyrrhizae Radix; Leguminosae; Phosphodiesterase

Indexed keywords

BARIUM CHLORIDE; CALCIMYCIN; CALCIUM IONOPHORE; CARBACHOL; COUMARIN DERIVATIVE; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; GLYCYCOUMARIN; GLYCYRRHIZAE RADIX EXTRACT; ISOBUTYLMETHYLXANTHINE; MILRINONE; PAPAVERINE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PLANT EXTRACT; POTASSIUM CHLORIDE; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; ENZYME INHIBITION; GLYCYRRHIZA; IC 50; INTESTINE CONTRACTION; JEJUNUM; MALE; MOUSE; NONHUMAN; PREMEDICATION; SMOOTH MUSCLE; SMOOTH MUSCLE RELAXATION; SPASMOLYSIS;

ANIMALS; CARBACHOL; COUMARINS; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHIZA URALENSIS; JEJUNUM; MALE; MICE; MICE, INBRED ICR; MUSCLE CONTRACTION; PARASYMPATHOLYTICS; PHOSPHODIESTERASE INHIBITORS;

ANIMALIA; FABACEAE; GLYCYRRHIZA;

EID: 33646120322     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.11.017     Document Type: Article

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