Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

Analytica Chimica Acta

Volumn 676, Issue 1-2, 2010, Pages 34-40

  Grohganz, Holger ^a   Gildemyn, Delphine ^a   Skibsted, Erik ^b   Flink, James M ^b   Rantanen, Jukka ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Chemometrics; Near infrared; Protein; Validation; Water content

Indexed keywords

CHEMOMETRICS; CROSS VALIDATION; GENERAL MODEL; KARL FISCHER TITRATION; LINEAR CORRELATION; LOWER DENSITY; MODEL-BASED; MULTI VARIATE ANALYSIS; NEAR INFRARED; PARTIAL LEAST SQUARE REGRESSION; ROOT MEAN SQUARE ERRORS; ROOT-MEAN-SQUARE ERROR OF PREDICTIONS; SAMPLE COMPOSITION; SAMPLE SETS; STANDARD NORMAL VARIATES; SUCROSE MIXTURES; VALIDATION; WATER CONTENT DETERMINATION;

BLOCK CODES; DRUG PRODUCTS; FORECASTING; INFRARED DEVICES; INFRARED SPECTROSCOPY; MEAN SQUARE ERROR; MULTIVARIANT ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PROTEINS; SUGAR (SUCROSE);

WATER CONTENT;

EXCIPIENT; HUMAN GROWTH HORMONE; INSULIN; MANNITOL; PROTEIN; SUCROSE; WATER;

ARTICLE; CALIBRATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; FREEZE DRYING; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; VALIDATION PROCESS; WATER CONTENT;

FREEZE DRYING; LEAST-SQUARES ANALYSIS; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; SPECTROSCOPY, NEAR-INFRARED; WATER;

EID: 77956173470     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2010.07.035     Document Type: Article

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