Engineering the enolase magnesium II binding site: Implications for its evolution

Biochemistry

Volumn 49, Issue 35, 2010, Pages 7582-7589

  Schreier, Bettina ^a   Höcker, Birte ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CARBOXYLIC ACIDS; CATALYSIS; CRYSTAL STRUCTURE; METAL IONS; ORGANIC ACIDS; PROTONS; QUANTUM CHEMISTRY; REACTION INTERMEDIATES;

ACTIVE SITE; ACTIVITY ASSAYS; APO-STATE; CATALYTIC MECHANISMS; CATALYTIC RESIDUE; CHARGE STABILIZATION; ENOLASE; GLYCOLYTIC ENZYME; HIGH RESOLUTION CRYSTAL STRUCTURE; MAGNESIUM IONS; PHOSPHOENOLPYRUVATES; POSITIVELY CHARGED; SIDE CHAINS;

MAGNESIUM;

ENOLASE; MAGNESIUM ION; MAGNESIUM;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR EVOLUTION; MUTATION; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHOPYRUVATE HYDRATASE; PROTEIN CONFORMATION;

EID: 77956168606     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100954f     Document Type: Article

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