Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation

International Immunology

Volumn 22, Issue 9, 2010, Pages 757-767

  Wijesundara, Danushka K ^a   Kumar, Sheetal ^a   Alsharifi, Mohammed ^a,b   Mullbacher, Arno ^a   Regner, Matthias ^a  

^a Biology and Environment   (Australia)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Ca2+; IFN; IFN ; Proliferation; R IFN

Indexed keywords

CALCIUM ION; CD69 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERFERON; OVALBUMIN; POLYCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CROSS LINKING; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, CD3; CALCIUM SIGNALING; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; INTERFERON TYPE I; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS;

EID: 77956140880     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq064     Document Type: Article

References (20)

1. Theofilopoulos, A. N., Baccula, R., Beutler, B. and Kono, D. H. 2005. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu. Rev. Immunol. 23:307.
2. Alsharifi, M., Lobigs, M., Regner, M., Lee, E., Koskinen, A. and Müllbacher, A. 2005. Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection. J. Immunol. 175:4635.
3. Braun, D., Caramalho, I. and Demengeot, J. 2002. IFN-alpha/beta enhances BCR-dependent B cell responses. Int. Immunol. 14:411.
4. Curtsinger, J. M., Valenzuela, J. O., Agarwal, P., Lins, D. and Mescher, M. F. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J. Immunol. 174:4465.
5. Curtsinger, J. M., Valenzuela, J. O., Agarwal, P., Lins, D. and Mescher, M. F. 2007. Signal 3 availability limits the CD8 T cell response to a solid tumor. J. Immunol. 178:6752.
6. Lafferty, K. J. and Cunningham, A. J. 1975. A new analysis of allogeneic interactions. Aust. J. Exp. Biol. Med. Sci. 53:27.
7. Zola, H. 2000. Markers of cell lineage, differentiation and activation. J. Biol. Regul. Homeost. Agents. 14:218.
8. Smith-Garvin, J. E., Koretzky, G. A. and Jordan, M. S. 2009. T cell activation. Annu. Rev. Immunol. 27:591.
9. Quah, B. J., Warren, H. S. and Parish, C. R. 2007. Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat. Protoc. 2:2049.
10. Sprent, J., Zhang, X., Sun, S. and Tough, D. 2000. T-cell proliferation in vivo and the role of cytokines. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355:317.
11. Testi, R., Phillips, J. H. and Lanier, L. L. 1989. T cell activation via Leu-23 (CD69). J. Immunol. 143:1123.
12. Sancho, D., Santis, A. G., Alonso-Lebrero, J. L., Viedma, F., Tejedor, R. and Sanchez-Madrid, F. 2000. Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors. J. Immunol. 165:3868.
13. Feske, S. 2007. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 7:690.
14. Quigley, M., Huang, X. and Yang, Y. 2008. STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. J. Immunol. 180:2158.
15. Alsharifi, M., Regner, M., Blanden, R. et al. 2006. Exhaustion of type I interferon response following an acute viral infection. J. Immunol. 177:3235.
16. Afkarian, M., Sedy, J. R., Yang, J. et al. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol. 3:549.
17. Sullivan, B. M., Juedes, A., Szabo, S. J., von Herrath, M. and Glimcher, L. H. 2003. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc. Natl Acad. Sci. USA 100:15818.
18. Marrack, P., Kappler, J. and Mitchell, T. 1999. Type I interferons keep activated T cells alive. J. Exp. Med. 189:521.
19. Tough, D. F., Borrow, P. and Sprent, J. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947.
20. Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J. and Murali-Krishna, K. 2005. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202:637.