Successful treatment for carriage of methicillin-resistant Staphylococcus aureus and importance of follow-up

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 9, 2010, Pages 4020-4025

  Mollema, F P N ^a   Severin, J A ^a   Nouwen, J L ^a   Ott, A ^a,b   Verbrugh, H A ^a   Vos, M C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Laboratory for Infectious Diseases   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; FUSIDIC ACID; GENTAMICIN; PSEUDOMONIC ACID; RIFAMPICIN; TRIMETHOPRIM;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CULTURE; CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG TREATMENT FAILURE; ERADICATION THERAPY; FEMALE; FOLLOW UP; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NOSE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROAT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; PROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; YOUNG ADULT;

EID: 77956107711     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01240-09     Document Type: Article

References (40)

1. Adra, M., and K. R. Lawrence. 2004. Trimethoprim/sulfamethoxazole for treatment of severe Staphylococcus aureus infections. Ann. Pharmacother. 38:338-341.
2. Ammerlaan, H. S., J. A. Kluytmans, H. F. Wertheim, J. L. Nouwen, and M. J. Bonten. 2009. Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review. Clin. Infect. Dis. 48:922-930.
3. Batra, R., A. C. Eziefula, D. Wyncoll, and J. Edgeworth. 2008. Throat and rectal swabs may have an important role in MRSA screening of critically ill patients. Intensive Care Med. 34:1703-1706.
4. Boyce, J. M. 1989. Methicillin-resistant Staphylococcus aureus. Detection, epidemiology, and control measures. Infect. Dis. Clin. North Am. 3:901-913.
5. Boyce, J. M., N. L. Havill, and B. Maria. 2005. Frequency and possible infection control implications of gastrointestinal colonization with methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol. 43:5992-5995.
6. Buehlmann, M., R. Frei, L. Fenner, M. Dangel, U. Fluckiger, and A. F. Widmer. 2008. Highly effective regimen for decolonization of methicillin-resistant Staphylococcus aureus carriers. Infect. Control Hosp. Epidemiol. 29:510-516.
7. Casewell, M. W., and R. L. Hill. 1986. Elimination of nasal carriage of Staphylococcus aureus with mupirocin ('pseudomonic acid') - a controlled trial. J. Antimicrob. Chemother. 17:365-372.
8. Casewell, M. W., and R. L. Hill. 1985. In-vitro activity of mupirocin ('pseudomonic acid') against clinical isolates of Staphylococcus aureus. J. Antimicrob. Chemother. 15:523-531.
9. Darouiche, R., C. Wright, R. Hamill, M. Koza, D. Lewis, and J. Markowski. 1991. Eradication of colonization by methicillin-resistant Staphylococcus aureus by using oral minocycline-rifampin and topical mupirocin. Antimicrob. Agents Chemother. 35:1612-1615.
10. Davies, E. A., A. M. Emmerson, G. M. Hogg, M. F. Patterson, and M. D. Shields. 1987. An outbreak of infection with a methicillin-resistant Staphylococcus aureus in a special care baby unit: value of topical mupirocin and of traditional methods of infection control. J. Hosp. Infect. 10:120-128.
11. Davis, K. A., J. J. Stewart, H. K. Crouch, C. E. Florez, and D. R. Hospenthal. 2004. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin. Infect. Dis. 39:776-782.
12. Dupeyron, C., B. Campillo, M. Bordes, E. Faubert, J. P. Richardet, and N. Mangeney. 2002. A clinical trial of mupirocin in the eradication of methicillin-resistant Staphylococcus aureus nasal carriage in a digestive disease unit. J. Hosp. Infect. 52:281-287.
13. EARSS. 2007. Annual report EARSS - 2006. RIVM, Bilthoven, Netherlands.
14. Ellison, R. T., III, F. N. Judson, L. C. Peterson, D. L. Cohn, and J. M. Ehret. 1984. Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections. West. J. Med. 140:735-740.
15. Frank, U., W. Lenz, E. Damrath, I. Kappstein, and F. D. Daschner. 1989. Nasal carriage of Staphylococcus aureus treated with topical mupirocin (pseudomonic acid) in a children's hospital. J. Hosp. Infect. 13:117-120.
16. Frenay, H. M., C. M. Vandenbroucke-Grauls, M. J. Molkenboer, and J. Verhoef. 1992. Long-term carriage, and transmission of methicillin-resistant Staphylococcus aureus after discharge from hospital. J. Hosp. Infect. 22:207-215.
17. Fung, S. K., M. Louie, and A. E. Simor. 2002. Combined topical and oral antimicrobial therapy for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) colonization in hospitalized patients. Can. J. Infect. Dis. 13:287-292.
18. Gemmell, C. G., D. I. Edwards, A. P. Fraise, F. K. Gould, G. L. Ridgway, and R. E. Warren. 2006. Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK. J. Antimicrob. Chemother. 57:589-608.
19. Grim, S. A., R. P. Rapp, C. A. Martin, and M. E. Evans. 2005. Trimethoprim-sulfamethoxazole as a viable treatment option for infections caused by methicillin-resistant Staphylococcus aureus. Pharmacotherapy 25:253-264.
20. Harbarth, S., S. Dharan, N. Liassine, P. Herrault, R. Auckenthaler, and D. Pittet. 1999. Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 43:1412-1416.
21. Harbarth, S., N. Liassine, S. Dharan, P. Herrault, R. Auckenthaler, and D. Pittet. 2000. Risk factors for persistent carriage of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 31:1380-1385.
22. Hill, R. L., G. J. Duckworth, and M. W. Casewell. 1988. Elimination of nasal carriage of methicillin-resistant Staphylococcus aureus with mupirocin during a hospital outbreak. J. Antimicrob. Chemother. 22:377-384.
23. Kerremans, J. J., J. Maaskant, H. A. Verbrugh, W. B. van Leeuwen, and M. C. Vos. 2008. Detection of methicillin-resistant Staphylococcus aureus in a low-prevalence setting by polymerase chain reaction with a selective enrichment broth. Diagn. Microbiol. Infect. Dis. 61:396-401.
24. Kluytmans, J., A. van Belkum, and H. Verbrugh. 1997. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev. 10:505-520.
25. Mertz, D., R. Frei, B. Jaussi, A. Tietz, C. Stebler, U. Fluckiger, and A. F. Widmer. 2007. Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus. Clin. Infect. Dis. 45:475-477.
26. Moran, G. J., A. Krishnadasan, R. J. Gorwitz, G. E. Fosheim, L. K. McDougal, R. B. Carey, and D. A. Talan. 2006. Methicillin-resistant S. aureus infections among patients in the emergency department. N. Engl. J. Med. 355:666-674.
27. Muder, R. R., M. Boldin, C. Brennen, M. Hsieh, R. M. Vickers, K. Mitchum, and Y. C. Yee. 1994. A controlled trial of rifampicin, minocycline, and rifampicin plus minocycline for eradication of methicillin-resistant Staphylococcus aureus in long-term care patients. J. Antimicrob. Chemother. 34:189-190.
28. Peterson, L. R., J. N. Quick, B. Jensen, S. Homann, S. Johnson, J. Tenquist, C. Shanholtzer, R. A. Petzel, L. Sinn, and D. N. Gerding. 1990. Emergence of ciprofloxacin resistance in nosocomial methicillin-resistant Staphylococcus aureus isolates. Resistance during ciprofloxacin plus rifampin therapy for methicillin-resistant S aureus colonization. Arch. Intern. Med. 150:2151-2155.
29. Reagan, D. R., B. N. Doebbeling, M. A. Pfaller, C. T. Sheetz, A. K. Houston, R. J. Hollis, and R. P. Wenzel. 1991. Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment. Ann. Intern. Med. 114:101-106.
30. Ringberg, H., A. C. Petersson, M. Walder, and P. J. H. Johansson. 2006. The throat: an important site for MRSA colonization. Scand. J. Infect. Dis. 38:888-893.
31. Stevens, D. L., A. L. Bisno, H. F. Chambers, E. D. Everett, P. Dellinger, E. J. Goldstein, S. L. Gorbach, J. V. Hirschmann, E. L. Kaplan, J. G. Montoya, and J. C. Wade. 2005. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin. Infect. Dis. 41:1373-1406.
32. Strausbaugh, L. J., C. Jacobson, D. L. Sewell, S. Potter, and T. T. Ward. 1992. Antimicrobial therapy for methicillin-resistant Staphylococcus aureus colonization in residents and staff of a Veterans Affairs nursing home care unit. Infect. Control Hosp. Epidemiol. 13:151-159.
33. Sutherland, R., R. J. Boon, K. E. Griffin, P. J. Masters, B. Slocombe, and A. R. White. 1985. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob. Agents Chemother. 27:495-498.
34. Thompson, R. L., I. Cabezudo, and R. P. Wenzel. 1982. Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. Ann. Intern. Med. 97:309-317.
35. Vos, M. C., M. D. Behrendt, D. C. Melles, F. P. N. Mollema, W. de Groot, G. Parlevliet, A. Ott, D. Horst-Kreft, A. van Belkum, and H. A. Verbrugh. 2009. MRSA Search and Destroy policy: 5-year experience in the largest University Medical Center of The Netherlands. Infect. Control Hosp. Epidemiol. 30:977-984.
36. Walsh, T. J., H. C. Standiford, A. C. Reboli, J. F. John, M. E. Mulligan, B. S. Ribner, J. Z. Montgomerie, M. B. Goetz, C. G. Mayhall, D. Rimland, et al. 1993. Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome. Antimicrob. Agents Chemother. 37:1334-1342.
37. Ward, A., and D. M. Campoli-Richards. 1986. Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 32:425-444.
38. Wertheim, H. F., M. C. Vos, H. A. Boelens, A. Voss, C. M. Vandenbroucke-Grauls, M. H. Meester, J. A. Kluytmans, P. H. van Keulen, and H. A. Verbrugh. 2004. Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use. J. Hosp. Infect. 56:321-325.
39. Widmer, A. F., D. Mertz, and R. Frei. 2008. Necessity of screening of both the nose and the throat to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit. J. Clin. Microbiol. 46:835.
40. WIP. 2003. Policy for methicillin-resistant Staphylococcus aureus. Dutch Working Party on Infection Prevention, Leiden, Netherlands.