Recombinant human erythropoietin plays a pivotal role as a topical stem cell activator to reverse effects of damage to the skin in aging and trauma

Rejuvenation Research

Volumn 13, Issue 4, 2010, Pages 499-500

  Bader, Augustinus ^a   MacHens, Hans Guenther ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; RECOMBINANT ERYTHROPOIETIN;

AGING; CELL ACTIVATION; CELL REGENERATION; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; SKIN DEFECT; SKIN INJURY; STEM CELL; TISSUE REGENERATION;

ERYTHROPOIETIN, RECOMBINANT; HUMANS; SKIN AGING; STEM CELLS; WOUNDS AND INJURIES;

EID: 77956102738     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2010.1064     Document Type: Letter

References (6)

1. Jahoda CA and Reynolds AJ. Hair follicle dermal sheath cells: Unsung participants in wound healing. Lancet 2001;358:1445-1448
2. Fernandes KJ, Toma JG, Miller FD. Multipotent skin-derived precursors: Adult neural crest-related precursors with therapeutic potential. Philos Trans R Soc Lond B Biol Sci 2008;363:185-198.
3. Bodó E, Kromminga A, Funk W, Laugsch M, Duske U, Jelkmann W, Paus R. Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J 2007;21:3346-3354.
4. Zhuang H, Niu Z, He TC, Patel SV, Wojchowski DM. Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2. J Biol Chem 1995;270: 14500-14504.
5. Galeano M, Altavilla D, Cucinotta D, Russo GT, Calò M, Bitto A, Marini H, Marini R, Adamo EB, Seminara P, Min-utoli L, Torre V, Squadrito F. Recombinant human erythro-poietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 2004;53:2509-2517.
6. Hamed S, Ullmann Y, Masoud M, Hellou E, Khamaysi Z, Teot L. Topical erythropoietin promotes wound repair in diabetic rats. J Invest Dermatol 2010;130:287-294.