DHA supplementation for late onset stargardt disease: NAT-3 study

Clinical Ophthalmology

Volumn 4, Issue 1, 2010, Pages 575-580

  Querques, Giuseppe ^a   Benlian, Pascale ^a   Chanu, Bernard ^b   Leveziel, Nicolas ^a   Coscas, Gabriel ^a   Soubrane, Gisele ^a   Souied, Eric H ^a  

^a UNIVERSITÉ PARIS EST CRÉTEIL   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

Docosahexaenoic acid (DHA); Multifocal electroretinogram; Omega 3; Polyunsaturated fatty acid; Retinal dystrophy; Stargardt disease

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID;

A WAVE; ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; B WAVE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG RESPONSE; ELECTRORETINOGRAM; ELOVL4 GENE; ERYTHROCYTE MEMBRANE; FATTY ACID BLOOD LEVEL; FEMALE; GENE; GENE MUTATION; HUMAN; LATE ONSET STARGARDT DISEASE; MALE; MULTIFOCAL ELECTRORETINOGRAM; PHOTODYNAMIC THERAPY; STARGARDT DISEASE; SUBRETINAL NEOVASCULARIZATION; SUPPLEMENTATION; VISUAL ACUITY;

EID: 77956099342     PISSN: 11775467     EISSN: 11775483     Source Type: Book Series    
DOI: 10.2147/opth.s10049     Document Type: Article

References (22)

1. Stargardt K. Ueber familiare progressive degeneration in der makulagegend des Auges. Albrecht V Graefes. Arch Ophthalmol. 1909;71:534-550.
2. Cibis GW, Morey M, Karris DJ. Dominantly inherited macular dystrophy with flecks (Stargardt). Arch Ophthalmol. 1980;98(10):1785.
3. Merlin S, Landau J. Abnormal findings in relatives of patients with juvenile hereditary macular degeneration (Stargardt's disease). Ophthalmologica. 1970;161(1):1.
4. Franceschetti A, Francois J. Fundus flavimaculatus. Arch Ophthalmol. 1965;25:505-530.
5. Allikmets R, Singh N, Sun H, et al. A photoreceptor cell-specific ATPbinding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997;15(3):236-246.
6. Cremers FP, van de Pol DJ, van Driel M, et al. Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR. Hum Mol Genet. 1998;7(3):355-362.
7. Rozet JM, Gerber S, Souied E, et al. Spectrum of ABCR gene mutations in autosomal recessive macular dystrophies. Eur J Hum Genet. 1998;6(3):291-295.
8. Aaberg TM. Stargardt's disease and fundus flavimaculatus: evaluation of morphologic progression and intrafamilial co-existence. Trans Am Ophthalmol Soc. 1980;84:453-487.
9. Lois N, Holder GE, Bunce C, Fitzke FW, Bird AC. Phenotypic subtypes of Stargardt macular dystrophy-fundus flavimaculatus. Arch Ophthalmol. 2001;119(3):359-369.
10. Ergun E, Hermann B, Wirtitsch M. Assessment of central visual function in Stargardts' disease/fundus flavimaculatus with ultrahigh- resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2005;46(1):310-316.
11. Hargitai J, Zernant J, Somfai GM, et al. Correlation of clinical and genetic findings in Hungarian patients with Stargardt disease. Invest Ophthalmol Vis Sci. 2005;46:4402-4408.
12. Kagan VE, Shvedova AA, Novikov KN. Participation of phospholipases in the "repair" of photoreceptor membranes subjected to peroxidation. Biofizika. 1978;23(2):279-84.
13. Terman A, Brunk UT. Lipofuscin: mechanisms of formation and increase with age. APMIS. 1998;106(2):265-76.
14. Wolman M. Oxidation of lipids and membranes I: in vitro formation of peroxidative lipid polymers. J Supramol Struct. 1975;3:80-9.
15. Tappel AL. Lipid peroxidation damage to cell components. Fed Proc. 1973;32(8):1870-4.
16. Feeney L, Berman ER. Oxygen toxicity: membrane damage by free radicals. Invest Ophthalmol. 1976;15(10):789-92.
17. Keys SA, Boley E, Zimmerman WF. A model membrane system to investigate antioxidants in bovine rod outer segments. Exp Eye Res. 1997;64(3):313-21.
18. Rotstein NP, Politi LE, German OL, Girotti R. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. Invest Ophthalmol Vis Sci. 2003;44(5):2252-2259.
19. MacDonald IM, Hebert M, Yau RJ, et al. Effect of docosahexaenoic acid supplementation on retinal function in a patient with autosomal dominant Stargardt-like retinal dystrophy. Br J Ophthalmol. 2004;88(2):305-306.
20. Xi ZP, Wang JY. Effect of dietary n-3 fatty acids on the composition of long- and very-long-chain polyenoic fatty acid in rat retina. J Nutr Sci Vitaminol. 2003;49(3):210-213.
21. Hubbard AF, Askew EW, Singh N, Leppert M, Bernstein PS. Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation. Arch Ophthalmol. 2006;124(2):257-263.
22. James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000;71(1 Suppl): 343S-348S.