Early diagnosis of intra-abdominal inflammation and sepsis by neutrophil CD64 expression in newborns

Neonatology

Volumn 99, Issue 2, 2011, Pages 118-124

  Lam, Hugh Simon ^a   Wong, Samuel Po Shing ^a   Cheung, Hon Ming ^a   Chu, Winnie Chiu Wing ^a   Wong, Raymond Pui On ^a   Chui, Kit Man ^a   Liu, Flora Yuen Big ^a   Li, Karen ^a   Fok, Tai Fai ^a   Ng, Pak Cheung ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Abdominal radiograph; C reactive protein; Necrotizing enterocolitis; Peritonitis

Indexed keywords

C REACTIVE PROTEIN; CD64 ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; DISSEMINATED INTRAVASCULAR CLOTTING; EARLY DIAGNOSIS; FEMALE; HUMAN; INTESTINE NECROSIS; INTESTINE PERFORATION; MAJOR CLINICAL STUDY; MALE; MELENA; NECROTIZING ARTERITIS; NEUTROPHIL; NEWBORN; NEWBORN DISEASE; NEWBORN SCREENING; PERITONITIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEPSIS; STOMACH DISTENSION; VERY LOW BIRTH WEIGHT; VOMITING;

BIOLOGICAL MARKERS; EARLY DIAGNOSIS; FEMALE; HUMANS; INFANT, NEWBORN; INFLAMMATION; MALE; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RECEPTORS, IGG; ROC CURVE; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 77956091008     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000311289     Document Type: Article

References (27)

1. Wales PW,De Silva N,Kim JH,Lecce L,Sandhu A,Moore AM: Neonatal short bowel syndrome: a cohort study. J Pediatr Surg 2005, 40: 755-762. (Pubitemid 40724842)
2. Lin PW, Stoll BJ: Necrotizing enterocolitis. Lancet 2006; 368: 1271-1283.
3. Grosfeld JL, Molinari F, Chaet M, Engum SA, West KW, Rescorla FJ, Scherer LR 3rd: Gastrointestinal perforation and peritonitis in infants and children: experience with 179 cases over ten years. Surgery 1996; 120: 650-655.
4. St-Vil D, LeBouthillier G, Luks FI, Bensoussan AL, Blanchard H, Youssef S: Neonatal gastrointestinal perforations. J Pediatr Surg 1992; 27: 1340-1342.
5. Moss RL, Dimmitt RA, Barnhart DC, Sylvester KG, Brown RL, Powell DM, Islam S, Langer JC, Sato TT, Brandt ML, Lee H, Blakely ML, Lazar EL, Hirschl RB, Kenney BD, Hackam DJ, Zelterman D, Silverman BL: Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation. N Engl J Med 2006; 354: 2225-2234. (Pubitemid 43788137)
6. Kaufman SS, Gondolesi GE, Fishbein TM: Parenteral nutrition associated liver disease. Semin Neonatol 2003; 8: 375-381. (Pubitemid 37237133)
7. Teitelbaum DH: Parenteral nutrition-associated cholestasis. Curr Opin Pediatr 1997; 9: 270-275. (Pubitemid 27336929)
8. Andorsky DJ, Lund DP, Lillehei CW, Jaksic T, Dicanzio J, Richardson DS, Collier SB, Lo C, Duggan C: Nutritional and other post-operative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr 2001; 139: 27-33. (Pubitemid 32613983)
9. Ng PC, Li K, Leung TF, Wong RP, Li G, Chui KM, Wong E, Cheng FW, Fok TF: Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6 and RANTES in preterm infants. Clin Chem 2006; 52: 1181-1189. (Pubitemid 43794433)
10. Ng PC, Cheng SH, Chui KM, Fok TF, Wong MY, Wong W, Wong RP, Cheung KL: Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecules, and C-reactive protein in preterm very low birth weight infants. Arch Dis Child Fetal Neonatal Ed 1997; 77:F221-F227. (Pubitemid 28201589)
11. Ng PC, Li K, Wong RP, Chui KM, Wong E, Fok TF: Neutrophil CD64 expression: a sensitive diagnostic marker of late-onset nosocomial infection in very low birthweight infants. Pediatr Res 2002; 51: 296-303. (Pubitemid 34174964)
12. Ng PC, Li K, Chui KM, Leung TF, Wong RP, Chu WC, Wong E, Fok TF: IP-10 is an early diagnostic marker for identification of lateonset bacteria infection in preterm infants. Pediatr Res 2007; 61: 93-98. (Pubitemid 46352323)
13. Ng PC, Li G, Chui KM, Chu WC, Li K, Wong RP, Chik KW, Wong E, Fok TF: Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatr Res 2004; 56: 796-803. (Pubitemid 39403408)
14. Ng PC, Lam HS: Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 2006; 18: 125-131.
15. Fjaertoft G, Håkansson L, Ewald U, Foucard T, Venge P: Neutrophils from term and preterm newborn infants express the high affinity Fcγ -receptor I (CD64) during bacterial infections. Pediatr Res 1999; 45: 871-876. (Pubitemid 29250098)
16. Bhandari V, Wang C, Rinder C, Rinder H: Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 2008; 121: 129-134.
17. Lam HS, Ng PC: Biochemical markers of neonatal sepsis. Pathology 2008; 40: 141-148.
18. Ng PC: Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 2004; 89:F229-F235. (Pubitemid 38570152)
19. Gupta SK, Burke G, Herson VC: Necrotizing enterocolitis: laboratory indicators of surgical disease. J Pediatr Surg 1994; 29: 1472-1475. (Pubitemid 24356247)
20. Morecroft JA, Spitz L, Hamilton PA, Holmes SJ: Plasma interleukin-6 and tumour necrosis factor levels as predictors of disease severity and outcome in necrotizing enterocolitis. J Pediatr Surg 1994; 29: 798-800. (Pubitemid 24191368)
21. Pourcyrous M, Korones SB, Yang W, Boulden TF, Bada HS: C-reactive protein in the diagnosis, management, and prognosis of neonatal necrotizing enterocolitis. Pediatrics 2005; 116: 1064-1069. (Pubitemid 46056409)
22. Turner D, Hammerman C, Rudensky B, Schlesinger Y, Wine E, Muise A, Schimmel MS: Low levels of procalcitonin during episodes of necrotizing enterocolitis. Dig Dis Sci 2007; 52: 2972-2976. (Pubitemid 47512547)
23. Chung JL, Kong MS, Lin SL, Lin TY, Huang CS, Lou CC, Lin JN: Diagnostic value of Creactive protein in children with perforated appendicitis. Eur J Pediatr 1996; 155: 529-531.
24. Gurleyik E, Gurleyik G, Unalmiser S: Accuracy of serum C-reactive protein measurements in diagnosis of acute appendicitis compared with surgeon's clinical impression. Dis Colon Rectum 1995; 38: 1270-1274.
25. Edelson MB, Sonnino RE, Bagwell CE, Lieberman JM, Marks WH, Rozycki HJ: Plasma intestinal fatty acid binding protein in neonates with necrotizing enterocolitis: a pilot study. J Pediatr Surg 1999; 34: 1453-1457. (Pubitemid 29503799)
26. Josefsson S, Bunn SK, Domellof M: Fecal calprotectin in very low birth weight infants. J Pediatr Gastroenterol Nutr 2007; 44: 407-413. (Pubitemid 46573221)
27. Icardi M, Erickson Y, Kilborn S, Stewart B, Grief B, Scharnweber G: CD64 index provides simple and predictive testing for the detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol DOI: 10.1128/JCM.00628-09.