메뉴 건너뛰기




Volumn 23, Issue 4, 2010, Pages 166-169

Preemptive therapy for cytomegalovirus based on real-time measurement of viral load in liver transplant recipients

Author keywords

Cytomegalovirus; Liver transplant; Preemptive therapy; Real time polymerase chain reaction

Indexed keywords

VALGANCICLOVIR;

EID: 77956061354     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.06.013     Document Type: Article
Times cited : (34)

References (31)
  • 1
    • 0029782102 scopus 로고    scopus 로고
    • Cytomegalovirus infection following liver transplantation: review of the literature
    • Kanj S.S., Sharara A.I., Clavien P.A., Hamilton J.D. Cytomegalovirus infection following liver transplantation: review of the literature. Clin Infect Dis 1996, 22:537-549.
    • (1996) Clin Infect Dis , vol.22 , pp. 537-549
    • Kanj, S.S.1    Sharara, A.I.2    Clavien, P.A.3    Hamilton, J.D.4
  • 2
    • 2942562338 scopus 로고    scopus 로고
    • CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays
    • Amorim M.L., Cabeda J.M., Seca R., Mendes A.C., Castro A.P., Amorim J.M. CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays. BMC Infect Dis 2001, 1:2.
    • (2001) BMC Infect Dis , vol.1 , pp. 2
    • Amorim, M.L.1    Cabeda, J.M.2    Seca, R.3    Mendes, A.C.4    Castro, A.P.5    Amorim, J.M.6
  • 3
    • 0031821865 scopus 로고    scopus 로고
    • Quantitation of cytomegalovirus: methodologic aspects and clinical applications
    • Boeckh M., Boivin G. Quantitation of cytomegalovirus: methodologic aspects and clinical applications. Clin Microbiol Rev 1998, 11:533-554.
    • (1998) Clin Microbiol Rev , vol.11 , pp. 533-554
    • Boeckh, M.1    Boivin, G.2
  • 4
    • 0029800728 scopus 로고    scopus 로고
    • Cytomegalovirus pp 65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind trial
    • Boeckh M., Gooley T.A., Myerson D., Cunningham T., Schoch G., Bowden R.A. Cytomegalovirus pp 65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind trial. Blood 1996, 88:4063-4071.
    • (1996) Blood , vol.88 , pp. 4063-4071
    • Boeckh, M.1    Gooley, T.A.2    Myerson, D.3    Cunningham, T.4    Schoch, G.5    Bowden, R.A.6
  • 5
    • 33747460001 scopus 로고    scopus 로고
    • Valganciclovir preemptive therapy for the prevention of cytomegalovirus disease in high-risk seropositive solid-organ transplant recipients
    • Diaz-Pedroche C., Lumbreras C., San Juan R., Folgueira D., Andrs A., Delgado J., et al. Valganciclovir preemptive therapy for the prevention of cytomegalovirus disease in high-risk seropositive solid-organ transplant recipients. Transplantation 2006, 82:30-35.
    • (2006) Transplantation , vol.82 , pp. 30-35
    • Diaz-Pedroche, C.1    Lumbreras, C.2    San Juan, R.3    Folgueira, D.4    Andrs, A.5    Delgado, J.6
  • 6
    • 0042384865 scopus 로고    scopus 로고
    • Pre-emptive therapy of CMV pp 65 antigen positive renal transplant recipients with oral ganciclovir; a randomized, comparative study
    • Sagedall S., Nordal K.P., Haartmann A., Midtvedt K., Foss A., Asberg A., et al. Pre-emptive therapy of CMV pp 65 antigen positive renal transplant recipients with oral ganciclovir; a randomized, comparative study. Nephrol Dial Transplant 2003, 18:1899-1908.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1899-1908
    • Sagedall, S.1    Nordal, K.P.2    Haartmann, A.3    Midtvedt, K.4    Foss, A.5    Asberg, A.6
  • 7
    • 0034666047 scopus 로고    scopus 로고
    • Cyomegalovirus antigenemia directed preemptive prophylaxis with oral versus I.V. ganciclovir for the prevention of cytomegalovirus diseases in liver transplant recipients: a randomized, controlled trial
    • Singh N., Paterson D.L., Gayowski T., Wagener M.M., Marino I.R. Cyomegalovirus antigenemia directed preemptive prophylaxis with oral versus I.V. ganciclovir for the prevention of cytomegalovirus diseases in liver transplant recipients: a randomized, controlled trial. Transplantation 2000, 70:717-2.
    • (2000) Transplantation , vol.70 , pp. 717-2
    • Singh, N.1    Paterson, D.L.2    Gayowski, T.3    Wagener, M.M.4    Marino, I.R.5
  • 8
    • 53649107879 scopus 로고    scopus 로고
    • Quantification of DNA in plasma by an automated real-time PCR assay (cytomegalovirus PCR kit) for surveillance of active cytomegalovirus infection and guidance of preemptive therapy for allogeneic hematopoietic stem cell transplant recipients
    • Gimeno C., Solano C., Latorre J.C., Hernandez-Boluda J.C., Clari M.A., Remigia M.J., et al. Quantification of DNA in plasma by an automated real-time PCR assay (cytomegalovirus PCR kit) for surveillance of active cytomegalovirus infection and guidance of preemptive therapy for allogeneic hematopoietic stem cell transplant recipients. J Clin Microbiol 2008, 46:3311-3318.
    • (2008) J Clin Microbiol , vol.46 , pp. 3311-3318
    • Gimeno, C.1    Solano, C.2    Latorre, J.C.3    Hernandez-Boluda, J.C.4    Clari, M.A.5    Remigia, M.J.6
  • 9
    • 34948871563 scopus 로고    scopus 로고
    • Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoitic stem-cell transplantation compared with qualitative pp65 antigenemia.
    • Lilleri D., Germna G., Furione M., Bernardo M.E., Giorgiani G., Telli S., et al. Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoitic stem-cell transplantation compared with qualitative pp65 antigenemia. Blood 2007, 110:2757-2760.
    • (2007) Blood , vol.110 , pp. 2757-2760
    • Lilleri, D.1    Germna, G.2    Furione, M.3    Bernardo, M.E.4    Giorgiani, G.5    Telli, S.6
  • 10
    • 34250221416 scopus 로고    scopus 로고
    • Real-time PCR assay compared with antigenemia assay for detecting cytomegalovirus infection in kidney transplant recipients
    • Kim D.J., Kim S.J., Park J., Choi G.S., Lee S., Kwon C.D., et al. Real-time PCR assay compared with antigenemia assay for detecting cytomegalovirus infection in kidney transplant recipients. Transplant Proc 2007, 39:1458-1460.
    • (2007) Transplant Proc , vol.39 , pp. 1458-1460
    • Kim, D.J.1    Kim, S.J.2    Park, J.3    Choi, G.S.4    Lee, S.5    Kwon, C.D.6
  • 11
    • 46149121948 scopus 로고    scopus 로고
    • Relationship of cytomegalovirus load assessed by real-time PCR to pp 65 antigenemia in organ transplant recipients
    • Sanghavi S.K., Abu-Elmagd K., Keightley M.C., St George K., Lewandowski K., Boes S.S., et al. Relationship of cytomegalovirus load assessed by real-time PCR to pp 65 antigenemia in organ transplant recipients. J Clin Virol 2008, 42:335-342.
    • (2008) J Clin Virol , vol.42 , pp. 335-342
    • Sanghavi, S.K.1    Abu-Elmagd, K.2    Keightley, M.C.3    St George, K.4    Lewandowski, K.5    Boes, S.S.6
  • 12
    • 70350738608 scopus 로고    scopus 로고
    • Comparison of quantitative cytomegalovirus real-time PCR in whole blood and pp 65 antigenemia assay: clinical utility of CMV real-time PCR in hematopoietic stem cell transplant recipients
    • Choi S.M., Lee D.G., Lim J., Park S.H., Choi J.H., Yoo J.H., et al. Comparison of quantitative cytomegalovirus real-time PCR in whole blood and pp 65 antigenemia assay: clinical utility of CMV real-time PCR in hematopoietic stem cell transplant recipients. J Korean Med Sci 2009, 24:571-578.
    • (2009) J Korean Med Sci , vol.24 , pp. 571-578
    • Choi, S.M.1    Lee, D.G.2    Lim, J.3    Park, S.H.4    Choi, J.H.5    Yoo, J.H.6
  • 13
    • 77955570946 scopus 로고    scopus 로고
    • A randomized controlled trial of plasma real-time PCR and antigenemia assay for monitoring CMV infection after unrelated BMT
    • doi:10.1038/bmt.2009.337
    • Kanda Y., Yamashita T., Mori T., Ito T., Tajika K., Mori S., et al. A randomized controlled trial of plasma real-time PCR and antigenemia assay for monitoring CMV infection after unrelated BMT. Bone Marrow Transplant 2009, doi:10.1038/bmt.2009.337.
    • (2009) Bone Marrow Transplant
    • Kanda, Y.1    Yamashita, T.2    Mori, T.3    Ito, T.4    Tajika, K.5    Mori, S.6
  • 14
    • 61849118521 scopus 로고    scopus 로고
    • Effect of cytomegalovirus viremia on subclinical rejection or interstitial fibrosis and tubular atrophy in protocol biopsy at 3months in renal allograft recipients managed by preemptive therapy or antiviral prophylaxis
    • Reischig T., Jindra P., Hes O., Bouda M., Kormunda S., Treska V. Effect of cytomegalovirus viremia on subclinical rejection or interstitial fibrosis and tubular atrophy in protocol biopsy at 3months in renal allograft recipients managed by preemptive therapy or antiviral prophylaxis. Transplantation 2009, 87:436-444.
    • (2009) Transplantation , vol.87 , pp. 436-444
    • Reischig, T.1    Jindra, P.2    Hes, O.3    Bouda, M.4    Kormunda, S.5    Treska, V.6
  • 15
    • 34548381266 scopus 로고    scopus 로고
    • Study on the viral load and antigenemaia as predictive values of CMV infection relapse in renal transplantation
    • Franco A., Serrano R., Gimeno A., de Juan J., Merino E., Jimenez del Cerro L., et al. Study on the viral load and antigenemaia as predictive values of CMV infection relapse in renal transplantation. Nefrologia 2007, 27:202-208.
    • (2007) Nefrologia , vol.27 , pp. 202-208
    • Franco, A.1    Serrano, R.2    Gimeno, A.3    de Juan, J.4    Merino, E.5    Jimenez del Cerro, L.6
  • 16
    • 0037090071 scopus 로고    scopus 로고
    • Definitions of cytomegalovirus infection and disease in transplant recipients
    • Ljungman P., Griffiths P., Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002, 34:1094-1097.
    • (2002) Clin Infect Dis , vol.34 , pp. 1094-1097
    • Ljungman, P.1    Griffiths, P.2    Paya, C.3
  • 17
    • 75449098274 scopus 로고    scopus 로고
    • Impact of pretransplant infections on clinical outcomes of liver transplant recipients
    • Sun H.Y., Cacciarelli T.V., Singh N. Impact of pretransplant infections on clinical outcomes of liver transplant recipients. Liver Transpl 2010, 16:222-228.
    • (2010) Liver Transpl , vol.16 , pp. 222-228
    • Sun, H.Y.1    Cacciarelli, T.V.2    Singh, N.3
  • 19
    • 69849087409 scopus 로고    scopus 로고
    • Prevention of cytomegalovirus disease using pre-emptive treatment after solid organ transplant in patients at high risk for cytomegalovirus infection
    • Benmarzouk-Hidalgo O.J., Cordero E., Martin-Pena A., Garcia-Prado E., Gentil M.A., Gomez-Bravo M.A., et al. Prevention of cytomegalovirus disease using pre-emptive treatment after solid organ transplant in patients at high risk for cytomegalovirus infection. Antivir Ther 2009, 14:641-647.
    • (2009) Antivir Ther , vol.14 , pp. 641-647
    • Benmarzouk-Hidalgo, O.J.1    Cordero, E.2    Martin-Pena, A.3    Garcia-Prado, E.4    Gentil, M.A.5    Gomez-Bravo, M.A.6
  • 20
    • 0033570914 scopus 로고    scopus 로고
    • Clinical utility of quantitative cytomegalovirus viral load determination for predicting cytomegalovirus disease in liver transplant recipients
    • Humar A., Gregson D., Caliendo A.M., McGeer A., Malkan G., Krajden M., et al. Clinical utility of quantitative cytomegalovirus viral load determination for predicting cytomegalovirus disease in liver transplant recipients. Transplantation 1999, 68:1306-1311.
    • (1999) Transplantation , vol.68 , pp. 1306-1311
    • Humar, A.1    Gregson, D.2    Caliendo, A.M.3    McGeer, A.4    Malkan, G.5    Krajden, M.6
  • 21
    • 0032964006 scopus 로고    scopus 로고
    • Quantity of human cytomegalovirus (CMV) DNAemia as a risk factor for CMV disease in renal allograft recipients: relationship with donor/recipient CMV serostatus, receipt of augmented methylprednisolone and antihymocyte globulin (ATG)
    • Hassan-Walker A.F., Kidd I.M., Sabin C., Sweny P., Griffiths P.D., Emery V.C. Quantity of human cytomegalovirus (CMV) DNAemia as a risk factor for CMV disease in renal allograft recipients: relationship with donor/recipient CMV serostatus, receipt of augmented methylprednisolone and antihymocyte globulin (ATG). J Med Virol 1999, 58:182-187.
    • (1999) J Med Virol , vol.58 , pp. 182-187
    • Hassan-Walker, A.F.1    Kidd, I.M.2    Sabin, C.3    Sweny, P.4    Griffiths, P.D.5    Emery, V.C.6
  • 22
    • 29544433928 scopus 로고    scopus 로고
    • Comparison of cytomegalovirus viral load measure by real-time PCR with pp65 antigenemia for the diagnosis of cytomegalovirus disease in solid organ transplant patients
    • Hernando S., Folgueira L., Lumbreras C., San Juan R., Maldonado S., Prieto C., et al. Comparison of cytomegalovirus viral load measure by real-time PCR with pp65 antigenemia for the diagnosis of cytomegalovirus disease in solid organ transplant patients. Transplant Proc 2005, 37:4094-4096.
    • (2005) Transplant Proc , vol.37 , pp. 4094-4096
    • Hernando, S.1    Folgueira, L.2    Lumbreras, C.3    San Juan, R.4    Maldonado, S.5    Prieto, C.6
  • 23
    • 12344298316 scopus 로고    scopus 로고
    • Efficacy of valganciclovir administered as preemptive therapy for cytomegalovirus disease in liver transplant recipients: impact on viral load and late-onset CMV disease
    • Singh N., Gayowski T., Wagener M.M., Cacciarelli T. Efficacy of valganciclovir administered as preemptive therapy for cytomegalovirus disease in liver transplant recipients: impact on viral load and late-onset CMV disease. Transplantation 2005, 79:85-90.
    • (2005) Transplantation , vol.79 , pp. 85-90
    • Singh, N.1    Gayowski, T.2    Wagener, M.M.3    Cacciarelli, T.4
  • 24
    • 0031944950 scopus 로고    scopus 로고
    • Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection
    • Gerna G., Zavattoni M., Percivalle E., Grossi P., Torsellini M., Grazia-Revello M. Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection. J Clin Microbiol 1998, 36:1113-1116.
    • (1998) J Clin Microbiol , vol.36 , pp. 1113-1116
    • Gerna, G.1    Zavattoni, M.2    Percivalle, E.3    Grossi, P.4    Torsellini, M.5    Grazia-Revello, M.6
  • 25
    • 11144273948 scopus 로고    scopus 로고
    • Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir
    • Mattes F.M., Hainsworth E.G., Hassan-Walker A.F., Burroughs A.K., Sweny P., Griffiths P.D., et al. Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir. J Infect Dis 2005, 191:89-92.
    • (2005) J Infect Dis , vol.191 , pp. 89-92
    • Mattes, F.M.1    Hainsworth, E.G.2    Hassan-Walker, A.F.3    Burroughs, A.K.4    Sweny, P.5    Griffiths, P.D.6
  • 26
    • 77949423996 scopus 로고    scopus 로고
    • Lack of prompt expansion of cytomegalovirus pp 65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients
    • Tormo N., Solano C., Benet I., Clari M.A., Nieto J., de la Camara R., et al. Lack of prompt expansion of cytomegalovirus pp 65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant 2010, 45:543-549.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 543-549
    • Tormo, N.1    Solano, C.2    Benet, I.3    Clari, M.A.4    Nieto, J.5    de la Camara, R.6
  • 27
    • 51849151201 scopus 로고    scopus 로고
    • Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: a systematic review
    • Sun H.Y., Wagener M.M., Singh N. Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: a systematic review. Am J Transplant 2008, 8:2111-2118.
    • (2008) Am J Transplant , vol.8 , pp. 2111-2118
    • Sun, H.Y.1    Wagener, M.M.2    Singh, N.3
  • 28
    • 77950468641 scopus 로고    scopus 로고
    • The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in high-risk kidney transplant recipients
    • Humar A., Lebranchu Y., Vincenti F., Blumberg E.A., Punch J.D., Limaye A.P., et al. The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in high-risk kidney transplant recipients. Am J Transplant 2010, 10(5):1228-1237.
    • (2010) Am J Transplant , vol.10 , Issue.5 , pp. 1228-1237
    • Humar, A.1    Lebranchu, Y.2    Vincenti, F.3    Blumberg, E.A.4    Punch, J.D.5    Limaye, A.P.6
  • 29
    • 77956064375 scopus 로고    scopus 로고
    • Primary CMV infections are common in kidney transplant recipients after 6months valganciclovir prophylaxis. American Transplant Congress. San Diego CA2010.
    • Helantera I, Kyllonen L, Lautenschlager I, Salmela K, Koskinen P. Primary CMV infections are common in kidney transplant recipients after 6months valganciclovir prophylaxis. American Transplant Congress. San Diego CA2010.
    • Helantera, I.1    Kyllonen, L.2    Lautenschlager, I.3    Salmela, K.4    Koskinen, P.5
  • 30
    • 0035062921 scopus 로고    scopus 로고
    • Prophylaxis for CMV should not now replace pre-emptive therapy in solid organ transplantation
    • Emery V.C. Prophylaxis for CMV should not now replace pre-emptive therapy in solid organ transplantation. Rev Med Virol 2001, 11:83-86.
    • (2001) Rev Med Virol , vol.11 , pp. 83-86
    • Emery, V.C.1
  • 31
    • 46349104637 scopus 로고    scopus 로고
    • Optimal prevention of late-onset cytomegalovirus (CMV) disease and other sequelae of CMV infection in organ transplant recipients
    • Author reply 7
    • Singh N. Optimal prevention of late-onset cytomegalovirus (CMV) disease and other sequelae of CMV infection in organ transplant recipients. Clin Infect Dis 2008, 47:296-297. Author reply 7.
    • (2008) Clin Infect Dis , vol.47 , pp. 296-297
    • Singh, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.