IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy

Muscle and Nerve

Volumn 42, Issue 3, 2010, Pages 433-435

  Kawagashira, Yuichi ^a   Kondo, Naohide ^a   Atsuta, Naoki ^a   Iijima, Masahiro ^a   Koike, Haruki ^a   Katsuno, Masahisa ^a   Tanaka, Fumiaki ^a   Kusunoki, Susumu ^b   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

MA; MGUS; Muscle atrophy; Peripheral neuropathy; Weakness

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN M; MYELIN ASSOCIATED GLYCOPROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; MALE; MOTOR DYSFUNCTION; MUSCLE ATROPHY; MUSCLE WEAKNESS; NERVE BIOPSY; NERVE CONDUCTION; NEUROPATHY; PRIORITY JOURNAL; SURAL NERVE;

CHARCOT-MARIE-TOOTH DISEASE; DIAGNOSIS, DIFFERENTIAL; ELECTRODIAGNOSIS; HUMANS; IMMUNOGLOBULIN M; IMMUNOGLOBULINS, INTRAVENOUS; LOWER EXTREMITY; MALE; MIDDLE AGED; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYELIN-ASSOCIATED GLYCOPROTEIN; NEURAL CONDUCTION; PARAPROTEINEMIAS;

EID: 77956046090     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.21741     Document Type: Article

References (15)

1. Martini R, Schachner M. Molecular bases of myelin formation as revealed by investigations on mice deficient in glial cell surface molecules. Glia 1997;19:298-310. (Pubitemid 27165237)
2. Lopate G, Kornberg AJ, Yue J, Choksi R, Pestronk A. Anti-myelin associated glycoprotein antibodies: variability in patterns of IgM binding to peripheral nerve. J Neurol Sci 2001;188:67-72. (Pubitemid 32727875)
3. Lunn MP, Crawford TO, Hughes RA, Griffin JW, Sheikh KA. Anti-myelin-associated glycoprotein antibodies alter neurofilament spacing. Brain 2002;125:904-911.
4. Latov N. Pathogenesis and therapy of neuropathies associated with monoclonal gammopathies. Ann Neurol 1995;37(suppl):S32-42.
5. Mendell JR, Sahenk Z, Whitaker JN, Trapp BD, Yates AJ, Griggs RC, et al. Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of anti-myelin-associated glycoprotein antibody. Ann Neurol 1985;17:243-254. (Pubitemid 15136598)
6. Vital A, Vital C, Julien J, Baquey A, Steck AJ. Polyneuropathy associated with IgM monoclonal gammopathy. Immunological and pathological study in 31 patients. Acta Neuropathol 1989;79:160-167.
7. Ellie E, Vital A, Steck A, Boiron JM, Vital C, Julien J. Neuropathy associated with "benign" anti-myelin-associated glycoprotein IgM gammopathy: clinical, immunological, neurophysiological and pathological findings and response to treatment in 33 cases. J Neurol 1996;243:34-43.
8. Chassande B, Léger JM, Younes-Chennoufi AB, Bengoufa D, Maisonobe T, Bouche P, et al. Peripheral neuropathy associated with IgM monoclonal gammopathy: correlations between M-protein antibody activity and clinical/electrophysiological features in 40 cases. Muscle Nerve 1998;21:55-62. (Pubitemid 28041681)
9. Nobile-Orazio E, Manfredini E, Carpo M, Meucci N, Monaco S, Ferrari S, et al. Frequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy. Ann Neurol 1994;36:416-424. (Pubitemid 24280063)
10. Kusunoki S, Craft JE, Roach B, Hardin JA, Yu RK. Neuropathy and IgM paraproteinemia: differential binding of IgM M-proteins to peripheral nerve glycolipids. Neurology 1987;37:1795-1797. (Pubitemid 17163725)
11. Kusunoki S, Chiba A, Kon K, Ando S, Arisawa K, Tate A, et al. N-acetylgalactosaminyl GD1a is a target molecule for serum antibody in Guillain-Barré syndrome. Ann Neurol 1994;35:570-576. (Pubitemid 24979404)
12. Yeung KB, Thomas PK, King RH, Waddy H, Will RG, Hughes RA, et al. The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings. J Neurol 1991;238:383-391.
13. Kaku DA, England JD, Sumner AJ. Distal accentuation of conduction slowing in polyneuropathy associated with antibodies to myelin-associated glycoprotein and sulphated glucuronyl paragloboside. Brain 1994;117:941-947.
14. Dyck PJ, Norell JE, Dyck PJ. Non-diabetic lumbosacral radiculoplexus neuropathy: natural history, outcome and comparison with the diabetic variety. Brain 2001;124:1197-1207.
15. Weiss MD, Dalakas MC, Lauter CJ, Willison HJ, Quarles RH. Variability in the binding of anti-MAG and anti-SGPG antibodies to target antigens in demyelinating neuropathy and IgM paraproteinemia. J Neuroimmunol 1999;95:174-184.