A stimuli-responsive hydrogel for doxorubicin delivery

Biomaterials

Volumn 31, Issue 31, 2010, Pages 8051-8062

  Dadsetan, Mahrokh ^a   Liu, Zen ^a   Pumberger, Matthias ^a,b   Giraldo, Catalina Vallejo ^a   Ruesink, Terry ^a   Lu, Lichun ^a   Yaszemski, Michael J ^a  

^a Mayo Clinic   (United States)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Chemotherapy; Controlled drug release; Drug delivery; Hydrogel; In vitro test

Indexed keywords

ANTI-TUMOR ACTIVITIES; ANTITUMOR DRUGS; CANCER CELLS; CANCER TREATMENT; CHARGED MOLECULE; CHEMOTHERAPEUTIC DRUGS; CONTROL GROUPS; CONTROLLED DRUG RELEASE; DOXORUBICIN; ELECTROSTATIC INTERACTIONS; HUMAN OSTEOSARCOMA CELLS; IN-VITRO TESTS; OLIGO(POLY(ETHYLENE GLYCOL)FUMARATE); PHOTOCROSS-LINKING; POLYMERIC CARRIERS; RELEASE KINETICS; SODIUM METHACRYLATES; STIMULI-RESPONSIVE; SURROUNDING ENVIRONMENT; SUSTAINED RELEASE;

CELL CULTURE; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; ETHYLENE; ETHYLENE GLYCOL; ION EXCHANGE; IONIC STRENGTH; OPTIMIZATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TUMORS;

HYDROGELS;

DOXORUBICIN; MACROGOL; OLIGO[POLY(ETHYLENE GLYCOL)FUMARATE]; SODIUM METHACRYLATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CELL LINE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HUMAN; HUMAN CELL; HYDROGEL; ION EXCHANGE; IONIC STRENGTH; KINETICS; OSTEOSARCOMA CELL; PH; POLYMERIZATION; PRIORITY JOURNAL; STATIC ELECTRICITY; STIMULUS RESPONSE; SUSTAINED DRUG RELEASE;

CELL DEATH; CELL LINE, TUMOR; COMPRESSIVE STRENGTH; CROSS-LINKING REAGENTS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FREEZE DRYING; HUMANS; HYDROGEL; METHACRYLATES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS;

EID: 77956012398     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.06.054     Document Type: Article

References (21)

1. Collier J.H., Camp J.P., Hudson T.W., Schmidt C.E. Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications. J Biomed Mater Res 2000, 50:574-584.
2. Kamada H., Tsutsumi Y., Yoshioka Y., Yamamoto Y., Kodaira H., Tsunoda S., et al. Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy. Clin Cancer Res 2004, 10:2545-2550.
3. Lai P.S., Lou P.J., Peng C.L., Pai C.L., Yen W.N., Huang M.Y., et al. Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J Control Release 2007, 122:39-46.
4. Hassan C.M., Stewart J.E., Peppas N.A. Diffusional characteristics of freeze/thawed poly(vinyl alcohol) hydrogels: applications to protein controlled release from multilaminate devices. Eur J Pharm Biopharm 2000, 49:161-165.
5. Minko T., Kopeckova P., Kopecek J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharm Res 1999, 16:986-996.
6. Brannon-Peppas L., Peppas N.A. Dynamic and equilibrium swelling behaviour of pH-sensitive hydrogels containing 2-hydroxyethyl methacrylate. Biomaterials 1990, 11:635-644.
7. Chan A.W., Neufeld R.J. Modeling the controllable pH-responsive swelling and pore size of networked alginate based biomaterials. Biomaterials 2009, 30:6119-6129.
8. Chan A.W., Whitney R.A., Neufeld R.J. Semisynthesis of a controlled stimuli-responsive alginate hydrogel. Biomacromolecules 2009, 10:609-616.
9. Jiang B., Li B. Tunable drug loading and release from polypeptide multilayer nanofilms. Int J Nanomedicine 2009, 4:37-53.
10. Qian F., Szymanski A., Gao J. Fabrication and characterization of controlled release poly(d, l-lactide-co-glycolide) millirods. J Biomed Mater Res 2001, 55:512-522.
11. LaVan D.A., McGuire T., Langer R. Small-scale systems for in vivo drug delivery. Nat Biotechnol 2003, 21:1184-1191.
12. Qian F., Stowe N., Liu E.H., Saidel G.M., Gao J. Quantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers. J Control Release 2003, 91:157-166.
13. Fleming A.B., Saltzman W.M. Pharmacokinetics of the carmustine implant. Clin Pharmacokinet 2002, 41:403-419.
14. Lowenthal R.M. Alternative cancer treatments. Med J Aust 1996, 165:536-537.
15. Klein-Szanto A.J. Carcinogenic effects of chemotherapeutic compounds. Prog Clin Biol Res 1992, 374:167-174.
16. Lewis A.L., Gonzalez M.V., Leppard S.W., Brown J.E., Stratford P.W., Phillips G.J., et al. Doxorubicin eluting beads - 1: effects of drug loading on bead characteristics and drug distribution. J Mater Sci Mater Med 2007, 18:1691-1699.
17. Lewis A.L., Taylor R.R., Hall B., Gonzalez M.V., Willis S.L., Stratford P.W. Pharmacokinetic and safety study of doxorubicin-eluting beads in a porcine model of hepatic arterial embolization. J Vasc Interv Radiol 2006, 17:1335-1343.
18. Lewis A.L., Gonzalez M.V., Lloyd A.W., Hall B., Tang Y., Willis S.L., et al. DC bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization. J Vasc Interv Radiol 2006, 17:335-342.
19. Jo S., Shin H., Mikos A.G. Modification of oligo(poly(ethylene glycol) fumarate) macromer with a GRGD peptide for the preparation of functionalized polymer networks. Biomacromolecules 2001, 2:255-261.
20. Dadsetan M., Knight A.M., Lu L., Windebank A.J., Yaszemski M.J. Stimulation of neurite outgrowth using positively charged hydrogels. Biomaterials 2009, 30:3874-3881.
21. Dadsetan M., Szatkowski J.P., Yaszemski M.J., Lu L. Characterization of photo-cross-linked oligo[poly(ethylene glycol) fumarate] hydrogels for cartilage tissue engineering. Biomacromolecules 2007, 8:1702-1709.