Combined vitamin C and vitamin e deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 9, 2010, Pages 1751-1757

  Babaev, Vladimir R ^a   Li, Liying ^a   Shah, Sanket ^a   Fazio, Sergio ^a   Linton, MacRae F ^a   May, James M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antioxidants; atherosclerosis; genetically altered mice; nutrition

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN E; ASCORBIC ACID; GULONOLACTONE OXIDASE; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SLC23A2 PROTEIN, MOUSE; SODIUM ASCORBIC ACID COTRANSPORTER; VITAMIN;

ALPHA TOCOPHEROL DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SINUS; ARTICLE; ASCORBIC ACID DEFICIENCY; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HYPERLIPOPROTEINEMIA TYPE 3; LIPID DIET; LIPID PEROXIDATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; AORTIC DISEASES; BRAIN; C57BL MOUSE; COMPLICATION; DEFICIENCY; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE MODEL; GENETICS; HEART MUSCLE; KNOCKOUT MOUSE; LIVER; METABOLISM; PATHOLOGY; SEVERITY OF ILLNESS INDEX; SEX DIFFERENCE; TIME; VITAMIN E DEFICIENCY;

ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; ATHEROSCLEROSIS; BRAIN; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; L-GULONOLACTONE OXIDASE; LIPID PEROXIDATION; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; OXIDATIVE STRESS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SYMPORTERS; TIME FACTORS; VITAMIN E; VITAMIN E DEFICIENCY; VITAMINS; SODIUM-COUPLED VITAMIN C TRANSPORTERS;

EID: 77955985049     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.209502     Document Type: Article

References (28)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
2. Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, Manson JE. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med. 2007;167:1610-1618.
3. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360:23-33.
4. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008;300:2123-2133.
5. Willis GC. An experimental study of the intimal ground substance in atherosclerosis. Can Med Assoc J. 1953;69:17-22.
6. Willis GC. The reversibility of atherosclerosis. Can Med Assoc J. 1957; 77:106-108.
7. Maeda N, Hagihara H, Nakata Y, Hiller S, Wilder J, Reddick R. Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci USA. 2000;97:841-846.
8. Nakata Y, Maeda N. Vulnerable atherosclerotic plaque morphology in apo-lipoprotein E-deficient mice unable to make ascorbic acid. Circulation. 2002; 105:1485-1490.
9. Aguirre R, May JM. Inflammation in the vascular bed: importance of vitamin C. Pharmacol Ther. 2008;119:96-103.
10. Stocker R, Keaney JF Jr. New insights on oxidative stress in the artery wall. J Thromb Haemost. 2005;3:1825-1834.
11. Niki E, Noguchi N, Tsuchihashi H, Gotoh N. Interaction among vitamin C, vitamin E, and/3-carotene. Am J Clin Nutr. 1995;62(suppl): 13322S-13326S.
12. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG, Farese RV Jr. Increased atherosclerosis in hyper-lipidemic mice deficient in a-tocopherol transfer protein and vitamin E. Proc Natl Acad Sci USA. 2000;97:13830-13834.
13. Suarna C, Wu BJ, Choy K, Mori T, Croft K, Cynshi O, Stocker R. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency. Free Radic Biol Med. 2006;41:722-730.
14. Sotiriou S, Gispert S, Cheng J, Wang YH, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med. 2002;8:514-517.
15. Davies I, Goddard C, Fotheringham AP, Moser B, Faragher EB. The effect of age on the control of water conservation in the laboratory mouse: metabolic studies. Exp Gerontol. 1985;20:53-66.
16. Fazio S, Babaev VR, Murray AB, Hasty AH, Carter KJ, Gleaves LA, Atkinson JB, Linton MF. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci USA. 1997;94:4647-4652.
17. Mendiratta S, Qu Z-C, May JM. Erythrocyte ascorbate recycling: antioxidant effects in blood. Free Radic Biol Med. 1998;24:789-797.
18. Lang JK, Gohil K, Packer L. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem. 1986;157:106-116.
19. Tebbe B, Wu SL, Geilen CC, Eberle J, Kodelja V, Orfanos CE. L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1a and IL-6 in cultured human keratinocytes in vitro. J Invest Dermatol. 1997;108:302-306.
20. Sabharwal AK, May JM. alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. Mol Cell Biochem. 2008;309:125-132.
21. Milne GL, Yin H, Brooks JD, Sanchez S, Jackson RL, Morrow JD. Quantification of f2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Methods Enzymol. 2007;433:113-126.
22. Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF. Macro-phage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem. 2000; 275:26293-26299.
23. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68: 231-240.
24. Kraal G, Rep M, Janse M. Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2: an immunohistochemical study. Scand J Immunol. 1987;26:653-661.
25. Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab. 2008;8:492-501.
26. Pratico D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med. 1998;4:1189-1192.
27. Cyrus T, Yao Y, Rokach J, Tang LX, Pratico D. Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptor-deficient mice with established vascular lesions. Circulation. 2003;107:521-523.
28. Roberts LJ, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med. 2007;43: 1388-1393.