Agrin immunohistochemistry facilitates the determination of primary versus metastatic origin of liver carcinomas

Human Pathology

Volumn 41, Issue 9, 2010, Pages 1310-1319

  Somorácz, Áron ^a   Tátrai, Péter ^a   Horváth, Gábor ^a   Kiss, András ^a   Kupcsulik, Péter ^a   Kovalszky, Ilona ^a   Schaff, Zsuzsa ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Agrin; Differential diagnosis; Immunohistochemistry; Liver cancer; Tissue origin

Indexed keywords

AGRIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER DIAGNOSIS; CANCER GRADING; CANCER SURGERY; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LIVER CARCINOMA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROVASCULATURE; PANCREAS CARCINOMA; PANCREAS DUCT; PRIMARY TUMOR; SENSITIVITY AND SPECIFICITY;

ADENOMA, LIVER CELL; ADULT; AGED; AGRIN; ANTIGENS, CD34; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CARCINOMA, HEPATOCELLULAR; CARCINOMA, PANCREATIC DUCTAL; CHOLANGIOCARCINOMA; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MICROVESSELS; MIDDLE AGED; PANCREATIC NEOPLASMS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 77955983812     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.10.029     Document Type: Article

References (24)

1. Elfaki D.H., Gossard A.A., and Lindor K.D. Cholangiocarcinoma: expanding the spectrum of risk factors J Gastrointest Cancer 39 2008 114 117
2. Khan S.A., Toledano M.B., and Taylor-Robinson S.D. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma HPB (Oxford) 10 2008 77 82
3. El-Serag H.B., and Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576
4. Kasper H.U., Drebber U., Dries V., and Dienes H.P. Liver metastases: incidence and histogenesis Z Gastroenterol 43 2005 1149 1157
5. Lau S.K., Prakash S., Geller S.A., and Alsabeh R. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma Hum Pathol 33 2002 1175 1181
6. Lódi C., Szabó E., and Holczbauer A. Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas Mod Pathol 19 2006 460 469
7. Baumhoer D., Tornillo L., Stadlmann S., Roncalli M., Diamantis E.K., and Terracciano L.M. Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples Am J Clin Pathol 129 2008 899 906
8. Kakar S., Gown A.M., Goodman Z.D., and Ferrell L.D. Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms Arch Pathol Lab Med 131 2007 1648 1654
9. Groffen A.J., Ruegg M.A., and Dijkman H. Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane J Histochem Cytochem 46 1998 19 27
10. Bezakova G., and Ruegg M.A. New insights into the roles of agrin Nat Rev Mol Cell Biol 4 2003 295 308
11. Williams S., Ryan C., and Jacobson C. Agrin and neuregulin, expanding roles and implications for therapeutics Biotechnol Adv 26 2008 187 201
12. Tátrai P., Dudás J., and Batmunkh E. Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma Lab Invest 86 2006 1149 1160
13. Batmunkh E., Tátrai P., and Szabó E. Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma Hum Pathol 38 2007 1508 1515
14. Tátrai P., Somorácz A., and Batmunkh E. Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions Am J Surg Pathol 33 2009 874 885
15. Sharma S., Camci C., and Jabbour N. Management of hepatic metastasis from colorectal cancers: an update J Hepatobiliary Pancreat Surg 15 2008 570 580
16. Llovet J.M., and Bruix J. Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
17. Aljiffry M., Abdulelah A., Walsh M., Peltekian K., Alwayn I., and Molinari M. Evidence-based approach to cholangiocarcinoma: a systematic review of the current literature J Am Coll Surg 208 2009 134 147
18. Briggs C.D., Neal C.P., Mann C.D., Steward W.P., Manson M.M., and Berry D.P. Prognostic molecular markers in cholangiocarcinoma: a systematic review Eur J Cancer 45 2009 33 47
19. Loos M., Kleeff J., Friess H., and Büchler M.W. Surgical treatment of pancreatic cancer Ann N Y Acad Sci 1138 2008 169 180
20. Hoeffel C., Mulé S., Romaniuk B., Ladam-Marcus V., Bouché O., and Marcus C. Advances in radiological imaging of gastrointestinal tumors Crit Rev Oncol Hematol 69 2009 153 167
21. Dennis J.L., Hvidsten T.R., and Wit E.C. Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm Clin Cancer Res 11 2005 3766 3772
22. Pang R., and Poon R.T. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma Cancer Lett 242 2006 151 167
23. Gupta G.P., and Massagué J. Cancer metastasis: building a framework Cell 127 2006 679 695
24. Harmer N.J. Insights into the role of heparan sulphate in fibroblast growth factor signalling Biochem Soc Trans 34 2006 442 445