The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4′-benzamido-2′-butenyl moiety: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6249-6257

  Benci, Kreimir ^a   Wittine, Karlo ^a   Radan, Malajka ^a   Cetina, Mario ^b   Sedić, Mirela ^c   Kraljević Pavelić, Sandra ^d   Pavelić, Kreimir ^d   Clercq, Erik De ^e   Mintas, Mladen ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

^d University of Rijeka   (Croatia)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activity; Cytostatic activity; Supramolecular self assembling; Unsaturated acyclic nucleoside analogues; X ray diffraction

Indexed keywords

1 ( 4' ( 4'' FLUORO)BENZAMIDE 2' BUTENYL)CYTOSINE; 1 ( 4' BENZAMIDE 2' BUTENYL) 5 FLUOROCYTOSINE; 1 ( 4' BENZAMIDE 2' BUTENYL) 5 FLUOROURACIL; 1 ( 4' BENZAMIDE 2' BUTENYL) 5 TRIFLUOROMETHYLURACIL; 1 ( 4' BENZAMIDE 2' BUTENYL)CYTOSINE; 1 ( 4' BENZAMIDE 2' BUTENYL)THYMINE; 1 ( 4' BENZAMIDE 2' BUTENYL)URACIL; 1 [ 4' ( 4'' FLUORO)BENZAMIDE 2' BUTENYL] 5 FLUOROCYTOSINE; 1 [ 4' ( 4'' FLUORO)BENZAMIDE 2' BUTENYL]THYMINE; 1 [ 4' ( 4'' FLUORO)BENZAMIDE 2' BUTENYL]URACIL; 1,3 DI( 4' BENZAMIDE 2' BUTENYL) 5 FLUOROURACIL; 3 ( 4' BENZAMIDE 2' BUTENYL) 5 TRIFLUOROMETHYLURACIL; 9 ( 4' BENZAMIDE 2' BUTENYL)ADENINE; ADENINE DERIVATIVE; BENZAMIDE; BENZAMIDE DERIVATIVE; BUTANE; CYTOSINE DERIVATIVE; DIMER; FLUOROURACIL DERIVATIVE; NUCLEOSIDE ANALOG; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSTASIS; CYTOTOXICITY; DRUG CONFORMATION; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY; SUBSTITUTION REACTION; SUPRAMOLECULAR CHEMISTRY; TUMOR CELL LINE; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

ADENINE; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; ISOMERISM; MOLECULAR STRUCTURE; NUCLEOSIDES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955982766     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.035     Document Type: Article

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