A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model

Developmental Biology

Volumn 345, Issue 2, 2010, Pages 226-236

  Nagamachi, Akiko ^a   Htun, Phyo Wai ^a,b   Ma, Feng ^c   Miyazaki, Kazuko ^a   Yamasaki, Norimasa ^a   Kanno, Masamoto ^b   Inaba, Toshiya ^a   Honda, Zen ichiro ^d   Okuda, Tsukasa ^e   Oda, Hideaki ^f   Tsuji, Kohichiro ^c   Honda, Hiroaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^f TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Hematopoiesis; Internal ribosome entry site (IRES); Leukemogenesis; Runx1; Runx1 Evi1

Indexed keywords

HYBRID PROTEIN; TRANSCRIPTION FACTOR RUNX1; 5' UNTRANSLATED REGION; RUNX1 PROTEIN, MOUSE;

5' UNTRANSLATED REGION; ACUTE LEUKEMIA; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; FETUS; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HEMATOPOIETIC CELL; HETEROZYGOTE; HOMOZYGOTE; INTERNAL RIBOSOME ENTRY SITE; LEUKEMOGENESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROMOTER REGION; RNA TRANSLATION; VASODILATATION; WILD TYPE; ANIMAL; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; LEUKEMIA; LIVER; METABOLISM; PATHOLOGY; RIBOSOME;

MUS;

5' UNTRANSLATED REGIONS; ANIMALS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCK-IN TECHNIQUES; HEMATOPOIESIS; HETEROZYGOTE; LEUKEMIA; LIVER; MICE; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; RIBOSOMES;

EID: 77955982742     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2010.07.015     Document Type: Article

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