-
1
-
-
38949141134
-
Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells
-
Azzariti A, Porcelli L, Gatti G, Nicolin A, Paradiso A (2008) Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells. Biochem Pharmacol 75: 1035-1044
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1035-1044
-
-
Azzariti, A.1
Porcelli, L.2
Gatti, G.3
Nicolin, A.4
Paradiso, A.5
-
2
-
-
27744432361
-
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
-
Belyanskaya LL, Hopkins-Donaldson S, Kurtz S, Simões-Wuest AP, Yousefi S, Simon HU, Stahel R, Zangemeister-Wittke U (2005) Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. Int J Cancer 117: 755-763
-
(2005)
Int J Cancer
, vol.117
, pp. 755-763
-
-
Belyanskaya, L.L.1
Hopkins-Donaldson, S.2
Kurtz, S.3
Simões-Wuest, A.P.4
Yousefi, S.5
Simon, H.U.6
Stahel, R.7
Zangemeister-Wittke, U.8
-
3
-
-
0035501672
-
Overexpression of the human major vault protein in astrocytic brain tumour cells
-
Berger W, Spiegl-Kreinecker S, Buchroithner J, Elbling L, Pirker C, Fischer J, Micksche M (2001) Overexpression of the human major vault protein in astrocytic brain tumour cells. Int J Cancer 94: 377-382
-
(2001)
Int J Cancer
, vol.94
, pp. 377-382
-
-
Berger, W.1
Spiegl-Kreinecker, S.2
Buchroithner, J.3
Elbling, L.4
Pirker, C.5
Fischer, J.6
Micksche, M.7
-
4
-
-
40349108627
-
Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs
-
Bianco R, Garofalo S, Rosa R, Damiano V, Gelardi T, Daniele G, Marciano R, Ciardiello F, Tortora G (2008) Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 98: 923-930
-
(2008)
Br J Cancer
, vol.98
, pp. 923-930
-
-
Bianco, R.1
Garofalo, S.2
Rosa, R.3
Damiano, V.4
Gelardi, T.5
Daniele, G.6
Marciano, R.7
Ciardiello, F.8
Tortora, G.9
-
5
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
6
-
-
0038514906
-
Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer
-
Blackhall FH, Pintilie M, Michael M, Leighl N, Feld R, Tsao MS, Shepherd FA (2003) Expression and prognostic significance of kit, protein kinase B, and mitogen-activated protein kinase in patients with small cell lung cancer. Clin Cancer Res 9: 2241-2247
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2241-2247
-
-
Blackhall, F.H.1
Pintilie, M.2
Michael, M.3
Leighl, N.4
Feld, R.5
Tsao, M.S.6
Shepherd, F.A.7
-
7
-
-
33845227643
-
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
-
Buck E, Eyzaguirre A, Brown E, Petti F, McCormack S, Haley JD, Iwata KK, Gibson NW, Griffin G (2006) Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 5: 2676-2684
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2676-2684
-
-
Buck, E.1
Eyzaguirre, A.2
Brown, E.3
Petti, F.4
McCormack, S.5
Haley, J.D.6
Iwata, K.K.7
Gibson, N.W.8
Griffin, G.9
-
8
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G (2008) EGFR antagonists in cancer treatment. N Engl J Med 358: 1160-1174
-
(2008)
N Engl J Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
9
-
-
67650252764
-
RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia
-
Crazzolara R, Bradstock KF, Bendall LJ (2009) RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy 5: 727-728
-
(2009)
Autophagy
, vol.5
, pp. 727-728
-
-
Crazzolara, R.1
Bradstock, K.F.2
Bendall, L.J.3
-
10
-
-
0031901936
-
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor
-
Damstrup L, Rude Voldborg B, Spang-Thomsen M, Bruenner N, Skovgaard Poulsen H (1998) In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor. Br J Cancer 78: 631-640
-
(1998)
Br J Cancer
, vol.78
, pp. 631-640
-
-
Damstrup, L.1
Rude Voldborg, B.2
Spang-Thomsen, M.3
Bruenner, N.4
Skovgaard Poulsen, H.5
-
11
-
-
34047272645
-
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activites against human cancer cells
-
Dornetshuber R, Heffeter P, Kamyar MR, Peterbauer T, Berger W, Lemmens-Gruber R (2007) Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activites against human cancer cells. Chem Res Toxicol 20: 465-473
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 465-473
-
-
Dornetshuber, R.1
Heffeter, P.2
Kamyar, M.R.3
Peterbauer, T.4
Berger, W.5
Lemmens-Gruber, R.6
-
12
-
-
34248578455
-
Targeting receptor tyrosine kinase signalling in small cell lung cancer (SLCL): What have we learned so far?
-
Fischer B, Marinov M, Arcaro A (2007) Targeting receptor tyrosine kinase signalling in small cell lung cancer (SLCL): what have we learned so far? Cancer Treat Rev 33: 391-406
-
(2007)
Cancer Treat Rev
, vol.33
, pp. 391-406
-
-
Fischer, B.1
Marinov, M.2
Arcaro, A.3
-
13
-
-
67649354927
-
Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells
-
Herberger B, Berger W, Puhalla H, Schmid K, Novak S, Brandstetter A, Pirker C, Gruenberger T, Filipits M (2009) Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells. Mol Cancer Ther 8: 1547-1556
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1547-1556
-
-
Herberger, B.1
Berger, W.2
Puhalla, H.3
Schmid, K.4
Novak, S.5
Brandstetter, A.6
Pirker, C.7
Gruenberger, T.8
Filipits, M.9
-
14
-
-
0035398631
-
Phase i and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C, Eckhardt SG, Tolcher A, Britten CD, Denis L, Ferrante K, vonHoff DD, Silberman S, Rowinsky EK (2001) Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19: 3267-3279
-
(2001)
J Clin Oncol
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
Rizzo, J.4
Hammond, L.A.5
Takimoto, C.6
Eckhardt, S.G.7
Tolcher, A.8
Britten, C.D.9
Denis, L.10
Ferrante, K.11
Vonhoff, D.D.12
Silberman, S.13
Rowinsky, E.K.14
-
15
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Global ARCC Trial
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, Kovacevic Z, Lesovoy V, Schmidt-Wolf IG, Barbarash O, Gokmen E, O Toole T, Lustgarten S, Moore L, Motzer RJ; Global ARCC Trial (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356: 2271-2281
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
16
-
-
33947495259
-
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
-
Iwamaru A, Kondo Y, Iwado E, Aoki H, Fujiwara K, Yokoyama T, Mills GB, Kondo S (2007) Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 26: 1840-1851
-
(2007)
Oncogene
, vol.26
, pp. 1840-1851
-
-
Iwamaru, A.1
Kondo, Y.2
Iwado, E.3
Aoki, H.4
Fujiwara, K.5
Yokoyama, T.6
Mills, G.B.7
Kondo, S.8
-
17
-
-
33947422073
-
Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy
-
Jimeno A, Kulesza P, Wheelhouse J, Chan A, Zhang X, Kincaid E, Chen R, Clark DP, Forastiere A, Hidalgo M (2007) Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. Br J Cancer 96: 952-959
-
(2007)
Br J Cancer
, vol.96
, pp. 952-959
-
-
Jimeno, A.1
Kulesza, P.2
Wheelhouse, J.3
Chan, A.4
Zhang, X.5
Kincaid, E.6
Chen, R.7
Clark, D.P.8
Forastiere, A.9
Hidalgo, M.10
-
18
-
-
0024438120
-
Expression of epidermal growth factor receptors in four histologic cell types of lung cancer
-
Kaseda S, Ueda M, Ozawa S, Ishihara T, Abe O, Shimizu N (1989) Expression of epidermal growth factor receptors in four histologic cell types of lung cancer. J Surg Oncol 42: 16-20
-
(1989)
J Surg Oncol
, vol.42
, pp. 16-20
-
-
Kaseda, S.1
Ueda, M.2
Ozawa, S.3
Ishihara, T.4
Abe, O.5
Shimizu, N.6
-
19
-
-
33845974091
-
Autophagy for cancer therapy through inhibition of proapoptotic proteins and mammalian target of rapamycin signaling
-
Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, Lu B (2006) Autophagy for cancer therapy through inhibition of proapoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 281: 36883-36890
-
(2006)
J Biol Chem
, vol.281
, pp. 36883-36890
-
-
Kim, K.W.1
Mutter, R.W.2
Cao, C.3
Albert, J.M.4
Freeman, M.5
Hallahan, D.E.6
Lu, B.7
-
20
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
21
-
-
33644770041
-
Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers: A Hoosier Oncology Group phase II trial
-
Moore AM, Einhorn LH, Estes D, Govindan R, Axelson J, Vinson J, Breen TE, Yu M, Hanna NH (2006) Gefitinib in patients with chemo-sensitive and chemo-refractory relapsed small cell cancers: a Hoosier Oncology Group phase II trial. Lung Cancer 52: 93-97
-
(2006)
Lung Cancer
, vol.52
, pp. 93-97
-
-
Moore, A.M.1
Einhorn, L.H.2
Estes, D.3
Govindan, R.4
Axelson, J.5
Vinson, J.6
Breen, T.E.7
Yu, M.8
Hanna, N.H.9
-
22
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
RECORD-1 Study Group
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, Gruenwald V, Thompson JA, Figlin RA, Hollaender N, Urbanowitz G, Berg WJ, Kay A, Lebwohl D, Ravaud A; RECORD-1 Study Group. (2008) Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372: 449-456
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Gruenwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Urbanowitz, G.11
Berg, W.J.12
Kay, A.13
Lebwohl, D.14
Ravaud, A.15
-
23
-
-
13944269488
-
Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance
-
Nakamura Y, Oka M, Soda H, Shiozawa K, Yoshikawa M, Itoh A, Ikegami Y, Tsurutani J, Nakatomi K, Kitazaki T, Doi S, Yoshida H, Kohno S (2005) Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance. Cancer Res 65: 1541-1546
-
(2005)
Cancer Res
, vol.65
, pp. 1541-1546
-
-
Nakamura, Y.1
Oka, M.2
Soda, H.3
Shiozawa, K.4
Yoshikawa, M.5
Itoh, A.6
Ikegami, Y.7
Tsurutani, J.8
Nakatomi, K.9
Kitazaki, T.10
Doi, S.11
Yoshida, H.12
Kohno, S.13
-
24
-
-
33646864481
-
EGFR mutation in gefitinib-responsive small-cell lung cancer
-
Okamoto I, Araki J, Suto R, Shimada M, Nakagawa K, Fukuoka M (2006) EGFR mutation in gefitinib-responsive small-cell lung cancer. Ann Oncol 17: 1028-1029
-
(2006)
Ann Oncol
, vol.17
, pp. 1028-1029
-
-
Okamoto, I.1
Araki, J.2
Suto, R.3
Shimada, M.4
Nakagawa, K.5
Fukuoka, M.6
-
25
-
-
33846202907
-
Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
-
Ono M, Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin Cancer Res 12: 7242-7251
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7242-7251
-
-
Ono, M.1
Kuwano, M.2
-
26
-
-
32944457518
-
MTOR inhibition induces upstream receptor kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N (2006) mTOR inhibition induces upstream receptor kinase signaling and activates Akt. Cancer Res 66: 1500-1508
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
-
27
-
-
71849097453
-
Phase II study of RAD001 (Everolimus) in previously treated small cell lung cancer
-
Owonikoko TK, Stoller RG, Petro D, Flaugh R, Hershberger PA, Belani CP, Argiris AE (2008) Phase II study of RAD001 (Everolimus) in previously treated small cell lung cancer. J Clin Oncol Suppl 26: 19017
-
(2008)
J Clin Oncol Suppl
, vol.26
, pp. 19017
-
-
Owonikoko, T.K.1
Stoller, R.G.2
Petro, D.3
Flaugh, R.4
Hershberger, P.A.5
Belani, C.P.6
Argiris, A.E.7
-
28
-
-
28844431555
-
A randomized, phase II ECOG trial of two dose levels of temsirolimus (CCI-779) in patients with extensive stage small cell lung cancer in remission after induction chemotherapy
-
Pandya KJ, Levy DE, Hidalgo M, Cohen RB, Lee MW, Schiller JH, Johnson DH (2005) A randomized, phase II ECOG trial of two dose levels of temsirolimus (CCI-779) in patients with extensive stage small cell lung cancer in remission after induction chemotherapy. J Clin Oncol Suppl 23: 7005
-
(2005)
J Clin Oncol Suppl
, vol.23
, pp. 7005
-
-
Pandya, K.J.1
Levy, D.E.2
Hidalgo, M.3
Cohen, R.B.4
Lee, M.W.5
Schiller, J.H.6
Johnson, D.H.7
-
29
-
-
76949106050
-
Treatment options for small cell lung cancer-do we have more choice?
-
Puglisi M, Dolly S, Faria A, Myerson JS, Popat S, O'Brien HE (2010) Treatment options for small cell lung cancer-do we have more choice? British J Cancer 102: 629-638
-
(2010)
British J Cancer
, vol.102
, pp. 629-638
-
-
Puglisi, M.1
Dolly, S.2
Faria, A.3
Myerson, J.S.4
Popat, S.5
O'Brien, H.E.6
-
30
-
-
33947501692
-
Mammalian target of rapamycin pathway activity in hepato-cellular carcinomas of patients undergoing liver transplantation
-
Sieghart W, Fuereder T, Schmid K, Cejka D, Werzowa J, Wrba F, Wang X, Gruber D, Rasoul-Rockenschaub S, Peck-Radosavljevic M, Wacheck V (2007) Mammalian target of rapamycin pathway activity in hepato-cellular carcinomas of patients undergoing liver transplantation. Transplantation 83: 425-432
-
(2007)
Transplantation
, vol.83
, pp. 425-432
-
-
Sieghart, W.1
Fuereder, T.2
Schmid, K.3
Cejka, D.4
Werzowa, J.5
Wrba, F.6
Wang, X.7
Gruber, D.8
Rasoul-Rockenschaub, S.9
Peck-Radosavljevic, M.10
Wacheck, V.11
-
31
-
-
16544385125
-
Small cell lung cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib ('Iressa', ZD1839
-
Tanno S, Ohsaki Y, Nakanishi K, Toyoshima E, Kikuchi K (2004) Small cell lung cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib ('Iressa', ZD1839). Oncol Rep 12: 1053-1057
-
(2004)
Oncol Rep
, vol.12
, pp. 1053-1057
-
-
Tanno, S.1
Ohsaki, Y.2
Nakanishi, K.3
Toyoshima, E.4
Kikuchi, K.5
-
32
-
-
33748058820
-
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibition in PTEN-deficient and PTEN-intact glioblastoma cells
-
Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, Mischel PS (2006) Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibition in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res 66: 7864-7869
-
(2006)
Cancer Res
, vol.66
, pp. 7864-7869
-
-
Wang, M.Y.1
Lu, K.V.2
Zhu, S.3
Dia, E.Q.4
Vivanco, I.5
Shackleford, G.M.6
Cavenee, W.K.7
Mellinghoff, I.K.8
Cloughesy, T.F.9
Sawyers, C.L.10
Mischel, P.S.11
-
33
-
-
26844545448
-
Overcoming cisplatin resistance by mTOR inhibitor in lung cancer
-
Wu C, Wangpaichitr M, Feun L, Kuo MT, Robles C, Lampidis T, Savaraj N (2005) Overcoming cisplatin resistance by mTOR inhibitor in lung cancer. Mol Cancer 4: 25
-
(2005)
Mol Cancer
, vol.4
, pp. 25
-
-
Wu, C.1
Wangpaichitr, M.2
Feun, L.3
Kuo, M.T.4
Robles, C.5
Lampidis, T.6
Savaraj, N.7
-
34
-
-
0023140620
-
Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line
-
Zijlstra JG, De Vries EG, Mulder NH (1987) Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res 47: 1780-1784
-
(1987)
Cancer Res
, vol.47
, pp. 1780-1784
-
-
Zijlstra, J.G.1
De Vries, E.G.2
Mulder, N.H.3
|