Production of the chiral compound (R)-3-hydroxybutyrate by a genetically engineered methylotrophic bacterium

Applied and Environmental Microbiology

Volumn 76, Issue 16, 2010, Pages 5585-5591

  Hölscher, Tina ^a   Breuer, Uta ^a   Adrian, Lorenz ^a,b   Harms, Hauke ^a   Maskow, Thomas ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^b BEC GmbH Biotechnic   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3-HYDROXYBUTYRATE; CHIRAL COMPOUNDS; CULTIVATION CONDITIONS; DEGRADING ENZYMES; DOUBLE MUTANTS; FED-BATCH CULTURES; GENETICALLY MODIFIED; INTRACELLULAR DEGRADATION; LIPOIC ACIDS; LOW GROWTH RATE; METHYLOBACTERIUM; METHYLOTROPHIC BACTERIA; NATURAL CONDITIONS; PHB ACCUMULATION; POLYHYDROXYBUTYRATE; SOLE SOURCE OF CARBON; STORAGE POLYMERS; SYNTHASES; TRANSPOSON MUTAGENESIS;

ACIDS; BATCH CELL CULTURE; CITRIC ACID; CULTIVATION; GENE ENCODING; GENETIC ENGINEERING; METHANOL; MUTAGENESIS;

DEGRADATION;

3 HYDROXYBUTYRIC ACID; BACTERIAL PROTEIN; CARBON; HYDROXYBUTYRATE DEHYDROGENASE; LIPOIC ACID SYNTHASE; METHANOL; SULFURTRANSFERASE; TRANSPOSON;

BACTERIUM; BIOACCUMULATION; BIODEGRADATION; BIOREACTOR; CARBON; CITRIC ACID; ENERGY; ENZYME ACTIVITY; FERMENTATION; GENETICALLY MODIFIED ORGANISM; GROWTH RATE; MUTAGENICITY;

ARTICLE; ENERGY METABOLISM; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHYLOBACTERIUM; MICROBIOLOGY; TRANSPOSON;

3-HYDROXYBUTYRIC ACID; BACTERIAL PROTEINS; CARBON; DNA TRANSPOSABLE ELEMENTS; ENERGY METABOLISM; GENE DELETION; HYDROXYBUTYRATE DEHYDROGENASE; INDUSTRIAL MICROBIOLOGY; METABOLIC NETWORKS AND PATHWAYS; METHANOL; METHYLOBACTERIUM; MUTAGENESIS, INSERTIONAL; SULFURTRANSFERASES;

BACTERIA (MICROORGANISMS); METHYLOBACTERIUM RHODESIANUM;

EID: 77955972763     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01065-10     Document Type: Article

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