The clinical manifestations and pathophysiology of cerebral small vessel disease

Neuroscience Bulletin

Volumn 26, Issue 3, 2010, Pages 257-264

  Zhang, Ai Juan ^a   Yu, Xin Jun ^a   Wang, Mei ^b  

^a Wei Fang Brain Hospital   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Binswanger's disease; Brain ischemia lood brain barrier; Gait disorder; Lacunar infarction; Urinary incontinence; Vascular dementia

Indexed keywords

BLOOD BRAIN BARRIER; BRAIN DISEASE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN VENTRICLE; CAUSAL ATTRIBUTION; CEREBRAL SMALL VESSEL DISEASE; CLINICAL FEATURE; COGNITIVE DEFECT; DEPRESSION; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; GAIT DISORDER; GENETIC RISK; HUMAN; HYPERTENSION; LEUKOARAIOSIS; MEMBRANE DAMAGE; METABOLIC REGULATION; MULTIINFARCT DEMENTIA; NEUROIMAGING; NONHUMAN; PATHOPHYSIOLOGY; RISK FACTOR; SHORT SURVEY; URINE INCONTINENCE; ANIMAL; BRAIN; CEREBROVASCULAR DISEASE; COMPLICATION; PATHOLOGY;

ANIMALS; BRAIN; CEREBROVASCULAR DISORDERS; HUMANS;

EID: 77955946385     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-010-1210-y     Document Type: Short Survey

References (59)

1. Zubkov AY, Uschmann H, Rabinstein AA. Rate of arterial occlusion n patients with acute ischemic stroke. Neurol Res 2008, 30 (8): 835-838.
2. Tomonaga M, Yamanouchi H, Tohgi H, Kameyama M. Clinicopathologic study of progressive subcortical vascular encephalopathy (Binswanger type) in the elderly. J Am Geriatr Soc 1982, 30(8): 524-529.
3. Nitkunan A, Charlton RA, Barrick TR, McIntyre DJ, Howe FA, Markus HS. Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease. NMR Biomed 2009, 22(3): 285-291.
4. Shrestha I, Takahashi T, Nomura E, Ohtsuki T, Ohshita T, Ueno H, et al. Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis. Hypertens Res 2009, 32(10): 869-874.
5. Fiehler J. Cerebral microbleeds: old leaks and new haemorrhages. Int J Stroke 2006, 1(3): 122-130.
6. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009, 8(2): 165-174.
7. Küker W. Imaging of cerebral vasculitis. Int J Stroke 2007, 2(3): 184-190.
8. Black S, Gao F, Bilbao J. Understanding white matter disease. Imaging-pathological correlations in Vascular Cognitive Impairment. Stroke 2009, 40(3 Suppl): S48-52.
9. Hendrikse J, Zwanenburg JJ, Visser F, Takahara T, Luijten P. Noninvasive depiction of the lenticulostriate arteries with time-of-flight MR angiography at 7.0 T. Cerebrovasc Dis 2008, 26 (6): 624-629.
10. Maurice Victor, Allan H, Roper. Adams and Victor's Principles of Neurology. 7th ed. 2001, 847-851.
11. Norrving B. Lacunar infarcts: no black holes in the brain are benign. Pract Neurol 2008, 8(4): 222-228.
12. Rapp JH, Pan XM, Neumann M, Hong M, Hollenbeck K, Liu J. Microemboli composed of cholesterol crystals disrupt the bloodbrain barrier and reduce cognition. Stroke 2008, 39(8): 2354-2361.
13. Rao R, Tah V, Casas JP, Hingorani A, Whittaker J, Smeeth L, et al. Ischaemic stroke subtypes and their genetic basis: A comprehensive meta-analysis of small and large vessel stroke. Eur Neurol 2008, 61(2): 76-86.
14. Staekenborg SS, van Straaten EC, van der Flier WM, Lane R, Barkhof F, Scheltens P. Small vessel versus large vessel vascular dementia: Risk factors and MRI findings. J Neurol 2008, 255 (11): 1644-1651.
15. Rosenberg GA. Inflammation and white matter damage in Vascular Cognitive Impairment. Stroke 2009, 40(3 Suppl): S20-23
16. Wen YD, Zhang HL, Qin ZH. Inflammatory mechanism in ischemic neuronal injury. Neurosci Bull 2006, 22(3): 171-182.
17. Silbert LC, Nelson C, Howieson DB, Moore MM, Kaye JA. Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline. Neurology 2008, 71(2): 108-113.
18. Ishii N, Nishihara Y, Imamura T. Why do frontal lobe symptoms predominate in vascular dementia with lacunes? Neurology 1986, 36(3): 340-345.
19. Rosano C, Newman AB, Katz R, Hirsch CH, Kuller LH. Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adults. J Am Geriatr Soc 2008, 56(9): 1618-1625.
20. Waite LM, Grayson DA, Piguet O, Creasey H, Bennett HP, Broe GA. Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. J Neurol Sci 2005, 229: 89-93.
21. Rosano C, Brach J, Longstreth Jr WT, Newman AB. Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults. Neuroepidemiology 2006, 26(1): 52-60.
22. Acharya HJ, Bouchard TP, Emery DJ, Camicioli RM. Axial signs and magnetic resonance imaging correlates in Parkinson's disease. Can J Neurol Sci 2007, 34(1): 56-61.
23. Srikanth V, Beare R, Blizzard L, Phan T, Stapleton J, Chen J, et al. Cerebral white matter lesions, gait, and the risk of incident falls: a prospective population-based study. Stroke 2009, 40(1): 175-180.
24. Sonohara K, Kozaki K, Akishita M, Nagai K, Hasegawa H, Kuzuya M, et al. White matter lesions as a feature of cognitive impairment, low vitality and other symptoms of geriatric syndrome in the elderly. Geriatr Gerontol Int 2008, 8(2): 93-100.
25. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, et al. Association of gait and balance disorders with agerelated white matter changes: the LADIS study. Neurology 2008, 70(12): 935-942.
26. Nadeau SE. Gait apraxia: further clues to localization. Eur Neurol 2007, 58(3): 142-145.
27. Denays R, Tondeur M, Noël P, Ham HR. Bilateral cerebral mediofrontal hypoactivity in Tc-99m HMPAO SPECT imaging. Clin Nucl Med 1994, 19(10): 873-876.
28. Wolfson L, Wei X, Hall CB, Panzer V, Wakefield D, Benson RR, et al. Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility. J Neurol Sci. 2005, 232(1-2): 23-27.
29. Sibon I, Fenelon G, Quinn NP, Tison F. Vascular parkinsonism. J Neurol 2004, 251(5): 513-524.
30. da Silva EG, Viana MA, Quagliato EM. Vascular parkinsonism: analysis of seven cases. Arq Neuropsiquiatr 2006, 64(3A): 568-571.
31. Factor SA. The clinical spectrum of freezing of gait in atypical parkinsonism. Mov Disord 2008, 23 (Suppl 2): S431-438.
32. Rektor I, Rektorová I, Kubová D. Vascular parkinsonism-an update. J Neurol Sci 2006, 248(1-2): 185-191.
33. Zijlmans JC, Daniel SE, Hughes AJ, Révész T, Lees AJ. Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis. Mov Disord 2004, 19(6): 630-640.
34. Ihara M, Tomimoto H, Ishizu K, Yoshida H, Sawamoto N, Hashikawa K, et al. Association of vascular parkinsonism with impaired neuronal integrity in the striatum. J Neural Transm 2007, 114(5): 577-584.
35. Kuo HK, Lipsitz LA. Cerebral white matter changes and geriatric syndromes: is there a link? J Gerontol A Biol Sci Med Sci 2004, 59(8): 818-826.
36. Hashimoto M, Mori E. Impact of white matter changes on clinical manifestation of Alzheimer's disease: A quantitative study. Stroke 2000, 31(9): 2182-2188.
37. Román GC, Royall DR. Executive control function: a rational basis for the diagnosis of vascular dementia. Alzheimer Dis Assoc Disord 1999, 13 (Suppl 3): S69-80.
38. Chen Y, Chen X, Mok VC, Lam WW, Wong KS, Tang WK. Poststroke depression in patients with small subcortical infarcts. Clin Neurol Neurosurg 2009, 111(3): 256-260.
39. Reyes S, Viswanathan A, Godin O, Dufouil C, Benisty S, Hernandez K, et al. Apathy: a major symptom in CADASIL. Neurology 2009, 72(10): 905-910.
40. Kato H, Yoshikawa T, Oku N, Imaizumi M, Takasawa M, Kimura Y, et al. Statistical parametric analysis of cerebral blood flow in vascular dementia with small-vessel disease using Tc-HMPAO SPECT. Cerebrovasc Dis 2008, 26(5): 556-562.
41. Huynh TJ, Murphy B, Pettersen JA, Tu H, Sahlas DJ, Zhang L, et al. CT perfusion quantification of small-vessel ischemic severity. AJNR Am J Neuroradiol 2008, 29(10): 1831-1836.
42. Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke 2004, 35(11): 2598-2603.
43. Bugalho P, Viana-Baptista M, Jordão C, Secca MF, Ferro JM. Age-related white matter lesions are associated with reduction of the apparent diffusion coefficient in the cerebellum. Eur J Neurol 2007, 14(9): 1063-1066.
44. Staals J, Pieters BM, Knottnerus IL, Rouhl RP, van Oostenbrugge RJ, Delanghe JR, et al. Haptoglobin polymorphism and lacunar stroke. Curr Neurovasc Res 2008, 5(3): 153-158.
45. Pruissen DM, Kappelle LJ, Rosendaal FR, Rouhl RP, van Oostenbrugge RJ, Delanghe JR. Prothrombotic gene variation in patients with large and small vessel disease. Neuroepidemiology 2008, 31(2): 89-92.
46. Quattrocolo G, Leombruni S, Vaula G, Bergui M, Riva A, Bradac GB, et al. Autosomal dominant late-onset leukoencephalopathy. Clinical report of a new Italian family. Eur Neurol 1997, 37(1): 53-61.
47. Rufa A, Blardi P, De Lalla A, Cevenini G, De Stefano N, Zicari E, et al. Plasma levels of asymmetric dimethylarginine in cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy. Cerebrovasc Dis 2008, 26(6): 636-640.
48. Huang Z, Jacewicz M, Pfeiffer RF. Anticardiolipin antibody in vascular parkinsonism. Mov Disord 2002, 17(5): 992-997.
49. Lee SJ, Kim JS, Lee KS, An JY, Kim W, Kim YI, et al. The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke. BMC Neurol 2008, 8: 31.
50. Zhou L, Chen Y, Sun N, Liu X. Family history of hypertension and arterial elasticity characteristics in healthy young people. Hypertens Res 2008, 31(5): 833-839.
51. Khan U, Crossley C, Kalra L, Rudd A, Wolfe CD, Collinson P, et al. Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study. Stroke 2008, 39(11): 2943-2949.
52. Huber JD. Diabetes, cognitive function, and the blood-brain barrier. Curr Pharm Des 2008, 14(16): 1594-1600.
53. Sachidanandam K, Hutchinson JR, Elgebaly MM, Mezzetti EM, Wang MH, Ergul A. Differential effects of diet-Induced dyslipidemia and hyperglycemia on mesenteric resistance artery structure and function in type 2 diabetes. J Pharmacol Exp Ther 2009, 328(1): 123-130.
54. Tomimoto H, Ihara M, Wakita H, Ohtani R, Lin JX, Akiguchi I, et al. Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat.Acta Neuropathol 2003, 106(6): 527-534.
55. Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, et al. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol 2008, 67(9): 842-856.
56. Bradley WG Jr, Whittemore AR, Watanabe AS, Davis SJ, Teresi LM, Homyak M. Association of deep white matter infarction with chronic communicating hydrocephalus: implications regarding the possible origin of normal-pressure hydrocephalus. AJNR Am J Neuroradiol 1991, 12(1): 31-39.
57. Choi JC. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy: a genetic cause of cerebral small vessel disease. J Clin Neurol 2010, 6(1): 1-9.
58. Quattrocolo G, Leombruni S, Vaula G, Bergui M, Riva A, et al. Autosomal dominant late-onset leukoencephalopathy. Clinical report of a new Italian family. Eur Neurol 1997, 37(1): 53-61.
59. Koennecke HC. Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications. Neurology 2006.