17β-Estradiol mediated protection against vascular leak after hemorrhagic shock: Role of estrogen receptors and apoptotic signaling

Shock

Volumn 34, Issue 3, 2010, Pages 229-235

  Childs, Ed W ^a   Tharakan, Binu ^a   Hunter, Felicia A ^a   Smythe, W Roy ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

caspase 3; Ischemia reperfusion; mitochondrial membrane potential; ROS

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; 5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYL CARBOCYANINE IODIDE; CASPASE 3; CYTOCHROME C; DIHYDRORHODAMINE 123; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORESCENT DYE; FULVESTRANT; PROPIONITRILE; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; UNCLASSIFIED DRUG; DIARYLPROPIONITRILE; DRUG DERIVATIVE; NITRILE; PROPIONIC ACID DERIVATIVE; PYRAZOLE DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL JUNCTION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; HEMORRHAGIC SHOCK; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; MESENTERY; MICROSCOPY; MICROVASCULATURE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT; RESUSCITATION; SIGNAL TRANSDUCTION; VENULE; ANIMAL; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE; VASCULARIZATION;

ANIMALS; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR MODULATORS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENTERY; MITOCHONDRIA; NITRILES; PROPIONATES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SHOCK, HEMORRHAGIC; TAMOXIFEN; VENULES;

EID: 77955942789     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181d75b50     Document Type: Article

References (39)

1. Baluk P, Hirata A, Thurston G, Fujiwara T, Neal CR, Michel CC, McDonald DM: Endothelial gaps: time course of formation and closure in inflamed venules of rats. Am J Physiol 272:155-170, 1997.
2. McDonald DM: Endothelial gaps: plasma leakage during inflammation. News Physiol Sci 13:104-105, 1998.
3. Childs EW, Udobi KF, Wood JG, Hunter FA, Smalley DM, Cheung LY: In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock 18:423-427, 2002.
4. Davidson MT, Deitch EA, Lu Q, Hasko G, Abungu B, Nemeth ZH, Zaets SB, Gaspers LD, Thomas AP, Xu DZ: Trauma-hemorrhagic shock mesenteric lymph induced endothelial apoptosis that involves both caspase-dependent and caspase-independent mechanisms. Ann Surg 240:123-131, 2004.
5. Mauriz JL, Gonzalez P, Jorquera F, Olcoz JL, González-Gallego J: Caspase inhibition does not protect against liver damage in hemorrhagic shock. Shock 19:33-37, 2003.
6. Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X: Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol 292P:H3179-H3189, 2007.
7. Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR: Angiopoietin1 inhibits intrinsic apoptotic signaling and vascular hyperperme-ability following hemorrhagic shock. Am J Physiol Heart Circ Physiol 294: H2285-H2295, 2008.
8. Kim JK, Pedram A, Razandi M, Levin ER: Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem 281:6760-6767, 2006.
9. Burkhardt M, Slotta JE, Garcia P, Seekamp A, Menger MD, Pohlemann T: The effect of estrogen on hepatic microcirculation after ischemia/reperfusion. Int J Colorectal Dis 23:113-119, 2008.
10. Duckles SP, Krause DN, Stirone C, Procaccio V: Estrogen and mitochondria: a new paradigm for vascular protection? Mol Interv 6:26-35, 2006.
11. Hildebrand F, Thobe BM, Hubbard WJ, Choudhry MA, Pape HC, Chaudry IH: Effects of 17beta-estradiol and flutamide on splenic macrophages and sple-nocytes after trauma-hemorrhage. Cytokine 36:107-114, 2006.
12. Suzuki T, Shimizu T, Yu HP, Hsieh YC, Choudhry MA, Chaudry IH: Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alpha. Am J Physiol Cell Physiol 292:C2103-C2111, 2007.
13. Caruso JM, Xu DZ, Lu Q, Dayal SD, Deitch EA: The female gender protects against pulmonary injury after trauma hemorrhagic shock. Surg Infect (Larchmt) 2:231-240, 2001.
14. Mizushima Y, Wang P, Jarrar D, Cioffi WG, Bland KI, Chaudry IH: Estradiol administration after trauma-hemorrhage improves cardiovascular and hepato-cellular functions in male animals. Ann Surg 232:673-679, 2000.
15. Lu A, Frink M, Choudhry MA, Schwacha MG, Hubbard WJ, Rue LW 3rd, Bland KI, Chaudry IH: Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis. Am J Physiol Endocrinol Metab 292:E585-E593, 2007.
16. Angele MK, Schwacha MG, Ayala A, Chaudry IH: Effect of gender and sex hormones on immune responses following shock. Shock 14:81-90, 2000.
17. Colburn P, Buonassisi V: Estrogen-binding sites in endothelial cell cultures. Science 201:817-819, 1978.
18. Venkov CD, Rankin AB, Vaughan DE: Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation 94:727-733, 1996.
19. Kim R, Emi M, Tanabe K: Caspase-dependent and-independent cell death pathways after DNA damage [Review]. Oncol Rep 14:595-599, 2005.
20. Alvarez RJ, Gips SJ, Moldovan N, Wilhide CC, Milliken EE, Hoang AT, Hruban RH, Silverman HS, Dang CV, Goldschmidt-Clermont PJ: 17Beta-estradiol inhibits apoptosis of endothelial cells. Biochem Biophys Res Commun 237:372-381, 1997.
21. Sugawara T, Noshita N, Lewen A, Gasche Y, Ferrand-Drake M, Fujimura M, Morita-Fujimura Y, Chan PH: Overexpression of copper/zinc superoxide dis-mutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 22:209-217, 2002.
22. Tharakan B, Hunter FA, Smythe WR, Childs EW: Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeabil-ity. Shock 30:571-577, 2008.
23. Van De Craen M, Berx G, Van Den Brande I, Fiers W, Declercq W, Vandenabeele P: Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis. FEBS Lett 458:167-170, 1999.
24. Hess RA, Gist DH, Bunick D, Lubahn DB, Farrell A, Bahr J, Cooke PS, Greene GL: Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract. J Androl 18:602-611, 1997.
25. Lindner V, Kim SK, Karas RH, Kuiper GG, Gustafsson JA, Mendelsohn ME: Increased expression of estrogen receptor-beta mRNA in male blood vessels after vascular injury. Circ Res 83:224-229, 1998.
26. Robertson JF: Estrogen receptor downregulators: new antihormonal therapy for advanced breast cancer. Clin Ther A17-A30, 2002.
27. Yin Y, Huang WW, Lin C, Chen H, MacKenzie A, Ma L: Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol Endocrinol 22:113-125, 2008.
28. Yager JD, Chen JQ: Mitochondrial estrogen receptors-new insights into specific functions. Trends Endocrinol Metab 18:89-91, 2007.
29. Childs EW, Udobi KF, Hunter FA, Dhevan V: Evidence of transcellular albumin transport after hemorrhagic shock. Shock 23:565-570, 2005.
30. Murao Y, Hata M, Ohnishi K, Okuchi K, Nakajima Y, Hiasa Y, Junger WG, Hoyt DB, Ohnishi T: Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock 20:23-28, 2003.
31. Savoye G, Tamion F, Richard V, Varin R, Thuillez C: Hemorrhagic shock resuscitation affects early and selective mesenteric artery endothelial function through a free radical-dependent mechanism. Shock 23:411-416, 2005.
32. Therade-Matharan S, Laemmel E, Duranteau J, Vicaut E: Reoxygenation after hypoxia and glucose depletion causes reactive oxygen species production by mitochondria in HUVEC. Am J Physiol Regul Integr Comp Physiol 287: R1037-R1043, 2004.
33. Petrosillo G, Ruggiero FM, Paradies G: Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J 17:2202-2208, 2003.
34. Morkuniene R, Arandarcikaite O, Borutaite V: Estradiol prevents release of cytochrome c from mitochondria and inhibits ischemia-induced apoptosis in perfused heart. Exp Gerontol 41:704-708, 2006.
35. Borutaite V, Jekabsone A, Morkuniene R, Brown GC: Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J Mol Cell Cardiol 35:357-366, 2003.
36. Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, Corsi A, Bianco P, Wolburg H, Moore R, Oreda B, et al.: The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 162:1111-1122, 2003.
37. Cervello M, Giannitrapani L, La Rosa M, Notarbartolo M, Labbozzetta M, Poma P, Montalto G, D'Alessandro N: Induction of apoptosis by the proteasome inhibitor MG1 32 in human HCC cells: possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation. Int J Mol Med 13:741-748, 2004.
38. Nakamoto K, Kuratsu J, Ozawa M: "-cleavage in non-apoptotic cells with reduced cell adhesion activity. Int J Mol Med 15:973-979, 2005.
39. Steinhusen U, Badock V, Bauer A, Behrens J, Wittman-Liebold B, Dörken B, Bommert K: Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem 275:16345-16353, 2000.