Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: Implications for patients with neuroendocrine tumor metastases and unknown primary site

Journal of Surgical Research

Volumn 163, Issue 1, 2010, Pages 47-51

  Wang, Yu Cheng ^a,b   Iezza, Gioia ^a,b   Zuraek, Marlene B ^a,b   Jablons, David M ^a,b   Theodore, Pierre R ^a,b   Bergsland, Emily K ^a,c   Donner, David B ^a,b   Warren, Robert S ^a,b   Nakakura, Eric K ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Surgery ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bronchopulmonary; neuroendocrine tumor; NKX2.2; typical carcinoid

Indexed keywords

CHROMOGRANIN A; CORTICOTROPIN; FORMALDEHYDE; SEROTONIN; TRANSCRIPTION FACTOR NKX2.2;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN METASTASIS; CANCER OF UNKNOWN PRIMARY SITE; CARCINOID; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; ECTOPIC HORMONE PRODUCTION; ENDOCRINE CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; MALE; NEUROENDOCRINE TUMOR; PHENOTYPE; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE FIXATION;

ADOLESCENT; ADULT; AGED; CARCINOID TUMOR; FEMALE; GASTROINTESTINAL NEOPLASMS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 77955925985     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.04.018     Document Type: Article

References (19)

1. O. Hauso, B.I. Gustafsson, and M. Kidd Neuroendocrine tumor epidemiology: Contrasting Norway and North America Cancer 113 2008 2655
2. M.B. Beasley, E. Brambilla, and W.D. Travis The 2004 World Health Organization classification of lung tumors Semin Roentgenol 40 2005 90
3. B.I. Gustafsson, M. Kidd, and A. Chan Bronchopulmonary neuroendocrine tumors Cancer 113 2008 5
4. B. Givi, S.J. Pommier, and A.K. Thompson Operative resection of primary carcinoid neoplasms in patients with liver metastases yields significantly better survival Surgery 140 2006 891 discussion 897
5. P. Hellman, T. Lundstrom, and U. Ohrvall Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases World J Surg 26 2002 991
6. M.H. Kulke, and R.J. Mayer Carcinoid tumors N Engl J Med 340 1999 858
7. P. Chu, E. Wu, and L.M. Weiss Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases Mod Pathol 13 2000 962
8. Y.C. Cai, B. Banner, J. Glickman, and R.D. Odze Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors Hum Pathol 32 2001 1087
9. S.N. Agoff, L.W. Lamps, and A.T. Philip Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors Mod Pathol 13 2000 238
10. A.M. Oliveira, H.D. Tazelaar, and J.L. Myers Thyroid transcription factor-1 distinguishes metastatic pulmonary from well-differentiated neuroendocrine tumors of other sites Am J Surg Pathol 25 2001 815
11. E.Z. Du, P. Goldstraw, and J. Zacharias TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location Hum Pathol 35 2004 825
12. A. Matoso, K. Singh, and R. Jacob Comparison of thyroid transcription factor-1 expression by 2 monoclonal antibodies in pulmonary and nonpulmonary primary tumors Appl Immunohistochem Mol Morphol 18 2009 142
13. A. Saqi, D. Alexis, and F. Remotti Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids Am J Clin Pathol 123 2005 394
14. X. Lin, R.S. Saad, and T.M. Luckasevic Diagnostic value of CDX-2 and TTF-1 expressions in separating metastatic neuroendocrine neoplasms of unknown origin Appl Immunohistochem Mol Morphol 15 2007 407
15. A. Srivastava, and J.L. Hornick Immunohistochemical staining for CDX-2, PDX-1, NESP-55, and TTF-1 can help distinguish gastrointestinal carcinoid tumors from pancreatic endocrine and pulmonary carcinoid tumors Am J Surg Pathol 33 2009 626
16. R.M. Mazziotta, A.C. Borczuk, and C.A. Powell CDX2 immunostaining as a gastrointestinal marker: Expression in lung carcinomas is a potential pitfall Appl Immunohistochem Mol Morphol 13 2005 55
17. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells. Development 1998;25:2213.
18. Y.C. Wang, E. Gallego-Arteche, and G. Iezza Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors Endocr Relat Cancer 16 2009 267
19. S. Desai, Z. Loomis, A. Pugh-Bernard, and S Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine Dev Biol 313 2008 58