Ventilatory function assessment in safety pharmacology: Optimization of rodent studies using normocapnic or hypercapnic conditions

Toxicology and Applied Pharmacology

Volumn 247, Issue 3, 2010, Pages 191-197

  Goineau, Sonia ^a   Rompion, Sonia ^a   Guillaume, Philippe ^a   Picard, Sandra ^a  

^a Porsolt and Partners Pharmacology   (France)

Author keywords

Airway function; Hypercapnia; Respiratory depression; Safety pharmacology; Whole body plethysmography

Indexed keywords

MORPHINE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY PLETHYSMOGRAPHY; BREATHING PATTERN; BRONCHODILATATION; CLINICAL ASSESSMENT TOOL; DRUG SENSITIVITY; EXPERIMENTAL GUINEA PIG; HYPERCAPNIA; MOUSE; NONHUMAN; RAT; RESPIRATORY FUNCTION; RISK ASSESSMENT; SPECIES COMPARISON;

ANIMALS; GUINEA PIGS; HYPERCAPNIA; MALE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; MORPHINE; PHARMACOLOGY; PLETHYSMOGRAPHY, WHOLE BODY; RATS; RATS, WISTAR; RESPIRATORY PHYSIOLOGICAL PROCESSES; SPECIES SPECIFICITY; THEOPHYLLINE;

ANIMALIA; CAVIA; MUS; RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 77955925340     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.06.012     Document Type: Article

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