Effects of long-term treatment with the GnrH agonist deslorelin (Suprelorin®) on sexual function in boars

Theriogenology

Volumn 74, Issue 5, 2010, Pages 733-740

  Kauffold, Johannes ^a   Rohrmann, Hartmut ^b   Boehm, Julia ^c   Wehrend, Axel ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Rohrmann Affiliation ^*  (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Boar; Castration; GnRH down regulation; Sexual function

Indexed keywords

DESLORELIN; DRUG DERIVATIVE; ENZYME INHIBITOR; SEX HORMONE; TRIPTORELIN;

ANIMAL; ARTICLE; BLOOD; CASTRATION; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MALE; PHYSIOLOGY; SPERMATOGENESIS; SWINE; TESTIS; TIME;

ANIMALS; CASTRATION; ENZYME INHIBITORS; GONADAL STEROID HORMONES; MALE; SPERMATOGENESIS; SWINE; TESTIS; TIME; TRIPTORELIN;

ANIMALIA; SUIDAE;

EID: 77955925293     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2010.03.026     Document Type: Article

References (33)

1. Bonneau M. Compounds responsible for boar taint, with special emphasis on androstenone: a review. Livest Prod Sci 1982, 9:687-707.
2. Xue J.L., Dial G.D. Raising intact male pigs for meat: Detecting and preventing boar taint. J Swine Health Prod 1997, 5:151-158.
3. Prunier A., Bonneau M., von Borell E.H., Cinotti S., Gunn M., Fredriksen B., Giersing M., Morton D.B., Tuyttens F.A.M., Velarde A. A review of the welfare consequences of surgical castration in piglets and the evaluation of non-surgical methods. Animal Welfare 2006, 15:277-289.
4. Zöls S., Ritzmann M., Heinritzi K. Effect of analgesics on the castration of male piglets. Berl Munch Tierarztl Wochenschr 2006, 119:193-196.
5. Schulz C., Ritzmann M., Palzer A., Otten W., Heinritzi K. [Changes in the concentration of noradrenaline and adrenaline before and after castration of piglets with and without isoflurane anesthesia]. Dtsch Tierarztl Wochenschr 2007, 114:454-459.
6. Dunshea F.R., Colantoni C., Howard K., McCauley I., Jackson P., Long K.A., Lopaticki S., Nugent E.A., Simons J.A., Walker J., Hennessy D.P. Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. J Anim Sci 2001, 79:2524-2535.
7. Metz C., Hohl K., Waidelich S., Drochner W., Claus R. Active immunization of boars against GnRH at an early age: consequences for testicular function, boar taint accumulation and N-retention. Livestock Production Science 2002, 74:147-157.
8. TM) on steroid hormones, boar taint compounds and performance in entire male pigs. Reprod Dom Anim 2008, 43:351-359.
9. Schmoll F., Kauffold J., Pfützner A., Baumgartner J., Brock F., Grodzycki M., Andrews S. Growth performance and carcass traits of boars raised in Germany and either surgically castrated or vaccinated against gonadotrophin-releasing hormone. J Swine Health Prod 2009, 17:250-255.
10. Fuchs T., Thun R., Parvizi N., Nathues H., Koehrmann A., Andrews S., Brock F., Klein G., Sudhaus N., Beilage E.G. Effect of a gonadotropin-releasing factor vaccine on follicle-stimulating hormone and luteinizing hormone concentrations and on the development of testicles and the expression of boar taint in male pigs. Theriogenology 2009, 72:672-680.
11. de Roest K., Montanari C., Fowler T., Baltussen W. Resource efficiency and economic implications of alternatives to surgical castration without anaesthesia. Animal 2009, 3:1522-1531.
12. Shalev E., Leung P.C. Gonadotropin-releasing hormone and reproductive medicine. J Obstet Gynaecol Can 2003, 25:98-113.
13. Schneider F., Tomek W., Grundker C. Gonadotropin-releasing hormone (GnRH) and its natural analogues: A review. Theriogenology 2006, 66:691-709.
14. Johnson C.A., Thompson D.L., Cartmill J.A. Pituitary responsiveness to GnRH in mares following deslorelin acetate implantation to hasten ovulation. J Anim Sci 2002, 80:2681-2687.
15. Volkmann D.H., Kutzler M.A., Wheeler R., Krekeler N. The use of deslorelin implants for the synchronization of estrous in diestrous bitches. Theriogenology 2006, 66:1497-1501.
16. Romagnoli S., Stelletta C., Milani C., Gelli D., Falomo M.E., Mollo A. Clinical use of deslorelin for the control of reproduction in the bitch. Reprod Domest Anim 2009, 44(Suppl 2):36-39.
17. Brüssow K.P., Torner H., Rátky J., Schneider F. The influence of GnRH agonist application on intraovarian oocyte development in gilts. Arch Tierzucht 1996, 39:78. (Abstr.).
18. Brüssow K.P., Schneider F., Rátky J. The influence of longtime active GnRH-agonist on hormonal level and follicular development in cyclic gilts. Reprod Domest Anim 1994, 29:355-361.
19. Schneider F., Falkenberg H., Kuhn G., Nürnberg K., Rehfeldt C., Kanitz W. Effects of treating young boars with a GnRH depot formulation on endocrine functions, testis size, boar taint, carcass composition and muscular structure. Anim Reprod Sci 1998, 50:69-80.
20. Trigg T.E., Doyle A.G., Walsh J.D., Swangchan-uthai T. A review of advances in the use of the GnRH agonist deslorelin in control of reproduction. Theriogenology 2006, 66:1507-1512.
21. Junaidi A., Williamson P.E., Martin G.B., Blackberry M.A., Cummins J.M., Trigg T.E. Dose-response studies for pituitary and testicular function in male dogs treated with the GnRH superagonist, deslorelin. Reprod Domest Anim 2009, 44:725-734.
22. Kopera I., Tuz R., Kotula-Balak M., Schwarz T., Koczanowski J., Bilinska B. Morphofunctional alterations in testicular cells of deslorelin-treated boars: an immunohistochemical study. J Exp Zool A Ecol Genet Physiol 2008, 309:117-126.
23. Kopera I., Tuz R., Hejmej A., Schwarz T., Koczanowski J., Bilinska B. Immunolocalization of androgen receptor in the boar epididymis: the effect of GnRH agonist deslorelin. Reprod Dom Anim 2009, 44:266-272.
24. Röcken F.E., Nothelfer H.B., Hoffmann B. Testosteronkonzentrationen im peripheren Plasma sowie morphologische Hodenbefunde von Rüden mit einer Perinealhernie. Kleintierpraxis 1995, 40:261-267.
25. Hoffmann B., Landeck A. Testicular endocrine function, seasonality and semen quality of the stallion. Anim Reprod Sci 1999, 57:89-98.
26. Hoffmann B., Goes de Pinho T., Schuler G. Determination of free and conjugated oestrogens in peripheral blood plasma, feces and urine of cattle throughout pregnancy. Exp Clin Endocrinol Diab 1997, 105:296-303.
27. Hoffmann B., Hoevler A., Hasan S.H., Failing K. Ovarian and pituitary function in dogs after hysterectomy. J Reprod Fert 1992, 96:837-845.
28. Goericke-Pesch S., Wehrend A. The use of GnRH-agonists in companion animal medicine. Tierärztliche Praxis 2009, 37(K):410-418.
29. Goericke-Pesch S., Spang A., Schulz M., Ozalp G., Bergmann M., Ludwig C., Hoffmann B. Recrudescence of spermatogenesis in the dog following downregulation using a slow release GnRH agonist implant. Reprod Domest Anim 2009, 44(Suppl 2):302-308.
30. Claus R. Messung des Ebergeruchsstoffes im Fett von Schweinen mittels eines Radioimmunotests, 1. Mitteilung: Geruchsdepotbildung in Abhaengigkeit vom Alter. Z Tierzuechtg Zuechtungsbiol 1975, 92:118-126.
31. Claus R., Rottner S., Rueckert C. Individual return to Leydig cell function after GnRH-immunization of boars. Vaccine 2008, 26:4571-4578.
32. Rottner S., Claus R. Return of testicular function after vaccination of boars against GnRH: consequences on testes histology. Animal 2009, 3:1279-1286.
33. Ludwig C., Desmoulins P.O., Driancourt M.A., Goericke-Pesch S., Hoffmann B. Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin as a removable implant "Gonazon"; a preclinical trial. Theriogenology 2009, 71:1037-1045.