메뉴 건너뛰기




Volumn 19, Issue 5, 2010, Pages 420-424

What is causing the mortality in treating the anemia of chronic kidney disease: Erythropoietin dose or hemoglobin level?

Author keywords

anemia; chronic kidney disease; erythropoiesis stimulating agent

Indexed keywords

ANTIANEMIC AGENT; HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN;

EID: 77955921322     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32833cf1d6     Document Type: Review
Times cited : (63)

References (34)
  • 1
    • 33750983605 scopus 로고    scopus 로고
    • CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease
    • Singh AK, Szczech L, Tang KL, et al., CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006; 355:2085-2098.
    • (2006) N Engl J Med , vol.355 , pp. 2085-2098
    • Singh, A.K.1    Szczech, L.2    Tang, K.L.3
  • 2
    • 70949108082 scopus 로고    scopus 로고
    • TREAT Investigators. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    • Pfeffer MA, Burdmann EA, Chen CY, et al., TREAT Investigators. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361:201 9-2032.
    • (2009) N Engl J Med , vol.361 , pp. 2019-2032
    • Pfeffer, M.A.1    Burdmann, E.A.2    Chen, C.Y.3
  • 3
    • 77149149102 scopus 로고    scopus 로고
    • Darbepoetin alfa and chronic kidney disease
    • author reply 655
    • Wright RJ, Kanagasundaram NS, Quinton R. Darbepoetin alfa and chronic kidney disease. N Engl J Med 2010; 362:653; author reply 655
    • (2010) N Engl J Med , vol.362 , pp. 653
    • Wright, R.J.1    Kanagasundaram, N.S.2    Quinton, R.3
  • 4
    • 75149198323 scopus 로고    scopus 로고
    • Does TREAT give the boot to ESAs in the treatment of CKD anemia?
    • Does TREAT give the boot to ESAs in the treatment of CKD anemia? J Am Soc Nephrol 2010; 21:2-6.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2-6
  • 5
    • 0032572913 scopus 로고    scopus 로고
    • The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
    • Besarab A, Bolton WK, Browne JK, et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 1998; 339:584-590.
    • (1998) N Engl J Med , vol.339 , pp. 584-590
    • Besarab, A.1    Bolton, W.K.2    Browne, J.K.3
  • 6
    • 33751002326 scopus 로고    scopus 로고
    • CREATE Investigators. Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    • DruekeTB, Locatelli F, Clyne N, etal., CREATE Investigators. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006; 355:2071-2084.
    • (2006) N Engl J Med , vol.355 , pp. 2071-2084
    • Drueketb Locatelli, F.1    Clyne, N.2
  • 7
    • 77952508045 scopus 로고    scopus 로고
    • Debate: PRO Position Should hemoglobin targets for anemic patients with chronic kidney disease be changed?
    • Singh AK. Debate: PRO Position. Should hemoglobin targets for anemic patients with chronic kidney disease be changed? Am J Nephrol 2010; 31:552-556.
    • (2010) Am J Nephrol , vol.31 , pp. 552-556
    • Singh, A.K.1
  • 8
    • 7444268479 scopus 로고    scopus 로고
    • Hematocrit was not validated as a surrogate end point for survival among epoetin-treated hemodialysis patients
    • Cotter DJ, Stefanik K, Zhang Y, et al. Hematocrit was not validated as a surrogate end point for survival among epoetin-treated hemodialysis patients. J Clin Epidemiol 2004; 57:1086-1095.
    • (2004) J Clin Epidemiol , vol.57 , pp. 1086-1095
    • Cotter, D.J.1    Stefanik, K.2    Zhang, Y.3
  • 9
    • 38449094145 scopus 로고    scopus 로고
    • Mechanism of increased mortality risk with erythropoietin treatment to higher hemoglobin targets
    • Fishbane S, Besarab A. Mechanism of increased mortality risk with erythropoietin treatment to higher hemoglobin targets. Clin J Am Soc Nephrol 2007; 2:1274-1282.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 1274-1282
    • Fishbane, S.1    Besarab, A.2
  • 10
    • 0033052842 scopus 로고    scopus 로고
    • Hematocrit level and associated mortality in hemodialysis patients
    • Ma JZ, Ebben J, Xia H, Collins AJ. Hematocrit level and associated mortality in hemodialysis patients. J Am Soc Nephrol 1999; 10:610-619.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 610-619
    • Ma, J.Z.1    Ebben, J.2    Xia, H.3    Collins, A.J.4
  • 11
    • 33645474065 scopus 로고    scopus 로고
    • Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patients
    • Regidor DL, Kopple JD, Kovesdy CP, et al. Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patients. J Am Soc Nephrol 2006; 17:1181-1191.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1181-1191
    • Regidor, D.L.1    Kopple, J.D.2    Kovesdy, C.P.3
  • 12
    • 0032991310 scopus 로고    scopus 로고
    • Hematocrit levels and hospitalization risks in hemodialysis patients
    • XiaH, Ebben J, MaJZ, Collins AJ. Hematocrit levels and hospitalization risks in hemodialysis patients. J Am Soc Nephrol 1999; 10:1309-1316.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1309-1316
    • Xiah Ebben, J.1    Ma, J.Z.2    Collins, A.J.3
  • 13
    • 0034765367 scopus 로고    scopus 로고
    • Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%
    • Collins AJ, Li S, St Peter W, et al. Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%. J Am Soc Nephrol 2001; 12:2465-2473.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 2465-2473
    • Collins, A.J.1    Li, S.2    St Peter, W.3
  • 14
    • 34648834848 scopus 로고    scopus 로고
    • The new FDA label for erythropoietin treatment: How does it affect hemoglobin target?
    • Fishbane S, Nissenson AR. The new FDA label for erythropoietin treatment: how does it affect hemoglobin target? Kidney Int 2007; 72:806-813.
    • (2007) Kidney Int , vol.72 , pp. 806-813
    • Fishbane, S.1    Nissenson, A.R.2
  • 15
    • 0035431030 scopus 로고    scopus 로고
    • Anemia-induced increase in the bleeding time: Implications for treatment of nonsurgical blood loss
    • Valeri CR, Cassidy G, Pivacek LE, et al. Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. Transfusion 2001; 41:977-983.
    • (2001) Transfusion , vol.41 , pp. 977-983
    • Valeri, C.R.1    Cassidy, G.2    Pivacek, L.E.3
  • 16
    • 0242298638 scopus 로고    scopus 로고
    • Hyperviscosity in polycythemia vera and other red cell abnormalities
    • Kwaan HC, Wang J. Hyperviscosity in polycythemia vera and other red cell abnormalities. Semin Thromb Hemost 2003; 29:451-458.
    • (2003) Semin Thromb Hemost , vol.29 , pp. 451-458
    • Kwaan, H.C.1    Wang, J.2
  • 17
    • 0034192225 scopus 로고    scopus 로고
    • Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans
    • Stohlawetz PJ, Dzirlo L, Hergovich N, et al. Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood 2000; 95:2983-2989.
    • (2000) Blood , vol.95 , pp. 2983-2989
    • Stohlawetz, P.J.1    Dzirlo, L.2    Hergovich, N.3
  • 18
    • 43749105165 scopus 로고    scopus 로고
    • High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO)
    • Kirkeby A, Torup L, Bochsen L, et al. High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO). Thromb Haemost 2008; 99:720-728.
    • (2008) Thromb Haemost , vol.99 , pp. 720-728
    • Kirkeby, A.1    Torup, L.2    Bochsen, L.3
  • 19
    • 54949128659 scopus 로고    scopus 로고
    • Endothelial activation markers in anemic nondialysis chronic kidney disease patients
    • Patel TV, Mittal BV, Keithi-Reddy SR, et al. Endothelial activation markers in anemic nondialysis chronic kidney disease patients. Nephron Clin Pract 2008; 110:c244-c250.
    • (2008) Nephron Clin Pract , vol.110
    • Patel, T.V.1    Mittal, B.V.2    Keithi-Reddy, S.R.3
  • 20
    • 33645827977 scopus 로고    scopus 로고
    • Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoa-gulant and vasoactive activities
    • Coleman TR, Westenfelder C, Togel FE, et al. Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoa-gulant and vasoactive activities. Proc Natl Acad Sci USA 2006; 103:5965-5970.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5965-5970
    • Coleman, T.R.1    Westenfelder, C.2    Togel, F.E.3
  • 21
    • 0032962029 scopus 로고    scopus 로고
    • Mechanism of erythropoietin-induced hypertension
    • Vaziri ND. Mechanism of erythropoietin-induced hypertension. Am J Kidney Dis 1999; 33:821-828.
    • (1999) Am J Kidney Dis , vol.33 , pp. 821-828
    • Vaziri, N.D.1
  • 22
    • 0033920429 scopus 로고    scopus 로고
    • Normalization of hematocrit in hemodialysis patients with cardiac disease does not increase blood pressure
    • Conlon PJ, Kovalik E, Schumm D, et al. Normalization of hematocrit in hemodialysis patients with cardiac disease does not increase blood pressure. Ren Fail 2000; 22:435-444.
    • (2000) Ren Fail , vol.22 , pp. 435-444
    • Conlon, P.J.1    Kovalik, E.2    Schumm, D.3
  • 23
    • 54149119169 scopus 로고    scopus 로고
    • Safety of ferumoxytol in patients with anemia and CKD
    • Singh A, Patel T, Hertel J, et al. Safety of ferumoxytol in patients with anemia and CKD. Am J Kidney Dis 2008; 52:907-915.
    • (2008) Am J Kidney Dis , vol.52 , pp. 907-915
    • Singh, A.1    Patel, T.2    Hertel, J.3
  • 24
    • 2542429341 scopus 로고    scopus 로고
    • Administration of parenteral iron and mortality among hemodialysis patients
    • Feldman HI, Joffe M, Robinson B, et al. Administration of parenteral iron and mortality among hemodialysis patients. J Am Soc Nephrol 2004; 15:1623-1632.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1623-1632
    • Feldman, H.I.1    Joffe, M.2    Robinson, B.3
  • 25
    • 40449087690 scopus 로고    scopus 로고
    • The nonhaematopoietic biological effects of erythropoietin
    • Arcasoy MO. The nonhaematopoietic biological effects of erythropoietin. Br J Haematol 2008; 141:14-31.
    • (2008) Br J Haematol , vol.141 , pp. 14-31
    • Arcasoy, M.O.1
  • 26
    • 77749317193 scopus 로고    scopus 로고
    • The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: A tale of two receptors
    • Brines M. The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors. Blood Purif 2010; 29:86-92.
    • (2010) Blood Purif , vol.29 , pp. 86-92
    • Brines, M.1
  • 27
    • 50849110807 scopus 로고    scopus 로고
    • Secondary analysis of the CHOIRtrial epoetin-alpha dose and achieved hemoglobin outcomes
    • Szczech LA, Barnhart HX, Inrig JK, etal. Secondary analysis of the CHOIRtrial epoetin-alpha dose and achieved hemoglobin outcomes. Kidney Int 2008; 74:791-798.
    • (2008) Kidney Int , vol.74 , pp. 791-798
    • Szczech, L.A.1    Barnhart, H.X.2    Inrig, J.K.3
  • 28
    • 77649193846 scopus 로고    scopus 로고
    • Comparative mortality risk of anemia management practices in incident hemodialysis patients
    • Brookhart MA, Schneeweiss S, Avorn J, et al. Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA 2010; 303:857-864.
    • (2010) JAMA , vol.303 , pp. 857-864
    • Brookhart, M.A.1    Schneeweiss, S.2    Avorn, J.3
  • 29
    • 7444256054 scopus 로고    scopus 로고
    • Epoetin requirements predict mortality in hemodialysis patients
    • Zhang Y, Thamer M, Stefanik K, etal. Epoetin requirements predict mortality in hemodialysis patients. Am J Kidney Dis 2004; 44:866-876.
    • (2004) Am J Kidney Dis , vol.44 , pp. 866-876
    • Zhang, Y.1    Thamer, M.2    Stefanik, K.3
  • 30
    • 52049121838 scopus 로고    scopus 로고
    • Erythropoietin, iron depletion, and relative thrombocytosis: A possible explanation for hemoglobin-survival paradox in hemodialysis
    • Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis. Am J Kidney Dis 2008; 52:727-736.
    • (2008) Am J Kidney Dis , vol.52 , pp. 727-736
    • Streja, E.1    Kovesdy, C.P.2    Greenland, S.3
  • 31
    • 68849087722 scopus 로고    scopus 로고
    • Anemia management and association of race with mortality and hospitalization in a large not-for-profit dialysis organization
    • Servilla KS, Singh AK, Hunt WC, et al. Anemia management and association of race with mortality and hospitalization in a large not-for-profit dialysis organization. Am J Kidney Dis 2009; 54:498-510.
    • (2009) Am J Kidney Dis , vol.54 , pp. 498-510
    • Servilla, K.S.1    Singh, A.K.2    Hunt, W.C.3
  • 32
    • 66149100104 scopus 로고    scopus 로고
    • Effect of epoetin alfa dose changes on hemoglobin and mortality in hemodialysis patients with hemoglobin levels persistently below 11 g/dl
    • Bradbury BD, Danese MD, Gleeson M, Critchlow CW. Effect of epoetin alfa dose changes on hemoglobin and mortality in hemodialysis patients with hemoglobin levels persistently below 11 g/dl. Clin J Am Soc Nephrol 2009; 4:630-637.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 630-637
    • Bradbury, B.D.1    Danese, M.D.2    Gleeson, M.3    Critchlow, C.W.4
  • 33
    • 66149151415 scopus 로고    scopus 로고
    • Estimated effect of epoetin dosage on survival among elderly hemodialysis patients in the United States
    • Zhang Y, Thamer M, Cotter D, et al. Estimated effect of epoetin dosage on survival among elderly hemodialysis patients in the United States. Clin J Am Soc Nephrol 2009; 4:638-644.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 638-644
    • Zhang, Y.1    Thamer, M.2    Cotter, D.3
  • 34
    • 77749334761 scopus 로고    scopus 로고
    • Relationship between epoetin alfa dose and mortality: Findings from a marginal structural model
    • Wang O, Kilpatrick RD, Critchlow CW, et al. Relationship between epoetin alfa dose and mortality: findings from a marginal structural model. Clin J Am Soc Nephrol 2010; 5:182-188.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 182-188
    • Wang, O.1    Kilpatrick, R.D.2    Critchlow, C.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.