CpG methylation modulates tissue-specific expression of a transgene in chickens

Theriogenology

Volumn 74, Issue 5, 2010, Pages

  Park, Sang Hyun ^a,b   Kim, Jin Nam ^a   Park, Tae Sub ^a   Lee, Seon Duk ^a   Kim, Tae Hyun ^a   Han, Beom Ku ^a   Han, Jae Yong ^b  

^a Optifarm Solution Inc   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

EGFP; Germline chimera; Methylation; Primordial germ cell (PGC); Transgenic chicken

Indexed keywords

AVES; GALLUS GALLUS; LENTIVIRUS; ROUS SARCOMA VIRUS;

EID: 77955918939     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2010.04.005     Document Type: Article

References (35)

1. Palmiter R.D., Norstedt G., Gelinas R.E., Hammer R.E., Brinster R.L. Metallothionein-human GH fusion genes stimulate growth of mice. Science 1983, 222:809-814.
2. Han J.Y. Germ cells and transgenesis in chickens. Comp Immunol Microbiol Infect Dis 2009, 32:61-80.
3. Love J., Gribbin C., Mather C., Sang H. Transgenic birds by DNA microinjection. Biotechnology 1994, 12:60-63.
4. Bosselman R.A., Hsu R.Y., Boggs T., Hu S., Bruszewski J., Ou S., Kozar L., Martin F., Green C., Jacobsen F., Nicolson M., Scholtz J.A., Semon K.M., Rishell W., Stewart R.G. Germline transmission of exogenous genes in the chicken. Science 1989, 243:533-535.
5. Thoraval P., Afanassieff M., Cosset F.L., Lasserre F., Verdier G., Coudert F., Dambrine G. Germline transmission of exogenous genes in chickens using helper-free ecotropic avian leukosis virus-based vectors. Transgenic Res 1995, 4:369-377.
6. Carsience R.S., Clark M.E., Gibbins V., Etches R.J. Germline chimeric chickens from dispersed donor blastodermal cells and compromised recipient embryos. Development 1993, 117:669-675.
7. Chang I.K., Jeong D.K., Hong Y.H., Park T.S., Moon Y.K., Ohno T., Han J.Y. Production of germline chimeric chicken by transfer of cultured primordial germ cells. Cell Biol Int 1997, 21:496-499.
8. Han J.Y., Park T.S., Hong Y.H., Jeong D.K., Kim J.N., Kim K.D., Lim J.M. Production of germline chimeras by transfer of chicken gonadal primordial germ cells maintained in vitro for an extended period. Theriogenology 2002, 58:1531-1539.
9. Park T.S., Hong Y.H., Kwon S.C., Lim J.M., Han J.Y. Birth of germline chimeras by transfer of chicken embryonic germ (EG) cells into recipient embryos. Mol Reprod Dev 2003, 65:389-395.
10. Park T.S., Jeong D.K., Kim J.N., Song K.H., Hong Y.H., Lim J.M., Han J.Y. Improved germline transmission in chicken chimeras produced by transplantation of gonadal primordial germ cells into recipient embryos. Biol Reprod 2003, 68:1657-1662.
11. Park T.S., Kim M.A., Lim J.M., Han J.Y. Production of quail (Coturnix japonica) germline chimeras derived from in vitro-cultured gonadal primordial germ cells. Mol Reprod Dev 2007, 75:274-281.
12. Kim M.A., Park T.S., Kim J.N., Park H.J., Lee Y.M., Ono T., Lim J.M., Han J.Y. Production of quail (Coturnix japonica) germline chimeras by transfer of gonadal primordial germ cells into recipient embryos. Theriogenology 2005, 63:774-782.
13. van de Lavoir M.C., Diamond J.H., Leighton P.A., Mather-Love C., Heyer B.S., Bradshaw R., Kerchner A., Hooi L.T., Gessaro T.M., Swanberg S.E., Delany M.E., Etches R.J. Germline transmission of genetically modified primordial germ cells. Nature 2006, 441:766-769.
14. McGrew M.J., Sherman A., Ellard F.M., Lillico S.G., Gilhooley H.J., Kingsman A.J., Mitrophanous K.A., Sang H. Efficient production of germline transgenic chickens using lentiviral vectors. EMBO Rep 2004, 5:728-733.
15. Chapman S.C., Lawson A., Macarthur W.C., Wiese R.J., Loechel R.H., Burgos-Trinidad M., Wakefield J.K., Ramabhadran R., Mauch T.J., Schoenwolf G.C. Ubiquitous GFP expression in transgenic chickens using a lentiviral vector. Development 2005, 132:935-940.
16. Scott B.B., Lois C. Generation of tissue-specific transgenic birds with lentiviral vectors. Proc Natl Acad Sci USA 2005, 99:2140-2145.
17. Lillico S.G., Sherman A., McGrew M.J., Robertson C.D., Smith J., Haslam C., Barnard P., Radcliffe P.A., Mitrophanous K.A., Elliot E.A., Sang H.M. Oviduct-specific expression of two therapeutic proteins in transgenic hens. Proc Natl Acad Sci USA 2007, 104:1771-1776.
18. Shin S.S., Kim T.M., Kim S.Y., Kim T.W., Seo H.W., Lee S.K., Kwon S.C., Lee G.S., Kim H., Lim J.M., Han J.Y. Generation of transgenic quail through germ cell-mediated germline transmission. FASEB J 2008, 22:2435-2444.
19. Bird A.P. Gene number, noise reduction and biological complexity. Trends Genet 1995, 11:94-100.
20. Hejnar J., Hajkova P., Plachy J., Elleder D., Stepanets V., Svoboda J. CpG island protects Rous sarcoma virus-derived vectors integrated into nonpermissive cells from DNA methylation and transcriptional suppression. Proc Natl Acad Sci USA 2001, 98:565-569.
21. Brooks A.R., Harkins R.N., Wang P., Qian H.S., Liu P., Rubanyi G.M. Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med 2004, 6:395-404.
22. Kim J.N., Kim M.A., Park T.S., Kim D.K., Park H.J., Ono T., Lim J.M., Han J.Y. Enriched gonadal migration of donor-derived gonadal primordial germ cells by immunomagnetic cell sorting in birds. Mol Reprod Dev 2004, 68:81-87.
23. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
24. Richards E.J., Elgin S.C. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 2002, 108:489-500.
25. Leighton P.A., van de Lavoir M.C., Diamona J.H., Xia C., Etches R.J. Genetic modification of primordial germ cells by gene trapping, gene targeting, and phiC31 integrase. Mol Reprod Dev 2008, 75:1163-1175.
26. Kamihira M., Nishijima K., Iijima S. Transgenic birds for the production of recombinant proteins. Adv Biochem Eng Biotechnol 2004, 91:171-189.
27. Jahner D., Stuhlmann H., Stewart C.L., Harbers K., Lohler J., Simon I., Jaenisch R. De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 1982, 298:623-628.
28. Hofmann A., Kessler B., Ewerling S., Kabermann A., Brem G., Wolf E., Pfeifer A. Epigenetic regulation of lentiviral transgene vectors in a large animal model. Mol Therapy 2006, 13:59-66.
29. Kang J., Park K., Chung Y., You J., Kim Y., Lee S., Hong S., Choi K., Heo K., Seol J., Lee J., Jin D., Park C., Seo J., Lee H., Han J. Coordinated change of a ratio of methylated H3-lysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig. Exp Mol Med 2007, 39:84-96.
30. Boulden A.M., Sealy L.J. Identification of a third protein factor which binds to the Rous Sarcoma virus LTR enhancer: Possible homology with the serum response factor. Virology 1990, 174:204-216.
31. Furth P.A., Hennighausen L., Baker C., Beatty B., Woychick R. The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice. Nucleic Acids Res 1991, 19:6205-6208.
32. Gorman C.M., Merlino G.T., Willingham M.C., Pastan I., Howard B.H. The Rous carcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci USA 1982, 79:6777-6781.
33. Chen P., Tian J., Kovesdi I., Bruder J.T. Promoters influence the kinetics of transgene expression following adenovector gene delivery. J Gene Med 2008, 10:123-131.
34. Reddy S.T., Stoker A.W., Bissell M.J. Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: Potential as stable genetic markers. Proc Natl Acad Sci USA 1991, 88:10505-10509.
35. Mizuarai S., Ono K., Yamaguchi K., Nishijima K., Kamihira M., Iijima S. Production of transgenic quails with high frequency of germ-line transmission using VSV-G pseudotyped retroviral vector. Biochem Biophysic Res Comm 2001, 286:456-463.