Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons

Xenotransplantation

Volumn 17, Issue 4, 2010, Pages 300-312

  Griesemer, Adam ^a   Liang, Fan ^a   Hirakata, Atsushi ^a   Hirsh, Erica ^a   Lo, Diana ^a   Okumi, Masayoshi ^a   Sykes, Megan ^a   Yamada, Kazuhiko ^a   Huang, Christene A ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Bone marrow; Chimerism; GalT Ko; Tolerance; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CELL ANTIBODY; COBROTOXIN; FLUCONAZOLE; HEPARIN; LOCD2B ANTIBODY; METRONIDAZOLE; PROSTACYCLIN; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BABOON; BONE MARROW; BONE MARROW TRANSPLANTATION; CYTOTOXICITY; DRUG DOSE TITRATION; ENGRAFTMENT; GRAFT INFECTION; HEMATOPOIETIC CELL; HUMORAL IMMUNITY; IMMUNOCOMPETENCE; KIDNEY TRANSPLANTATION; MICROCHIMERISM; MIXED LYMPHOCYTE REACTION; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; RADIATION DOSE; SPLENECTOMY; STEM CELL; SWINE; T CELL DEPLETION; THROMBOTIC THROMBOCYTOPENIC PURPURA; WHOLE BODY RADIATION;

ANIMALS; ANTIBODIES; ANTIGENS; BONE MARROW; BONE MARROW TRANSPLANTATION; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; HUMANS; PAPIO; RABBITS; RATS; SWINE; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HETEROLOGOUS;

EID: 77955911837     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2010.00600.x     Document Type: Article

References (35)

1. Sachs DH, Sykes M, Robson M, Cooper DK. Xenotransplantation. Adv Immunol 2001 79 : 129 223.
2. Starzl TE, Murase N, Tsakis A et al. Clinical xenotransplantation. Xenotransplantation 1994 1 : 3 7.
3. Tseng YL, Sachs DH, Cooper DK. Porcine hematopoietic progenitor cell transplantation in nonhuman primates: a review of progress. Transplantation 2005 79 : 1 9.
4. Lee LA, Sergio JJ, Sykes M. Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells. Transplantation 1996 61 : 125 132.
5. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989 169 : 493 502.
6. Huang CA, Fuchimoto Y, Scheier-Dolberg R et al. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model. J Clin Invest 2000 105 : 173 181.
7. Kawai T, Cosimi AB, Colvin RB et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995 59 : 256 262.
8. Fudaba Y, Spitzer TR, Shaffer J et al. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant 2006 6 : 2121 2133.
9. Kawai T, Cosimi AB, Spitzer TR et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008 358 : 353 361.
10. Sharabi Y, Aksentijevich I, Sundt TM et al. Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen. J Exp Med 1990 172 : 195 202.
11. Bartholomew AM, Powelson J, Sachs DH et al. Tolerance in a concordant nonhuman primate model. Transplantation 1999 68 : 1708 1716.
12. Sablinski T, Emery DW, Monroy R et al. Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors. Transplantation 1999 67 : 972 977.
13. Kozlowski T, Monroy R, Xu Y et al. Anti-Gal(alpha)1-3Gal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction. Transplantation 1998 66 : 176 182.
14. Buhler L, Awwad M, Basker M et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation 2000 69 : 2296 2304.
15. Buhler L, Alwayn IP, Basker M et al. CD40-CD154 pathway blockade requires host macrophages to induce humoral unresponsiveness to pig hematopoietic cells in baboons. Transplantation 2001 72 : 1759 1768.
16. Buhler L, Awwad M, Treter S et al. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation 2002 73 : 12 22.
17. Lai L, Kolber-Simonds D, Park KW et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002 295 : 1089 1092.
18. Kolber-Simonds D, Lai L, Watt SR et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004 101 : 7335 7340.
19. Tseng YL, Dor FJ, Kuwaki K et al. Bone marrow transplantation from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Xenotransplantation 2004 11 : 361 370.
20. Barth RN, Yamamoto S, Lamattina JC et al. Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness. Transplantation 2003 75 : 1615 1624.
21. Sablinski J, Latinne D, Gianello P. Xenotransplantation of pig kidneys to nonhuman primates. I: Development of the model. Xenotransplantation 1995 2 : 264 270.
22. Pennington LR, Sakamoto K, Popitz-Bergez FA et al. Bone marrow transplantation in miniature swine. I. Development of the model. Transplantation 1988 45 : 21 26.
23. Buhler L, Goepfert C, Kitamura H et al. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant 2001 27 : 1227 1236.
24. Pettitt AR, Clark RE. Thrombotic microangiopathy following bone marrow transplantation. Bone Marrow Transplant 1994 14 : 495 504.
25. Alwayn IP, Buhler L, Appel JZ et al. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation 2001 71 : 1601 1609.
26. Kozlowski T, Monroy R, Giovino M et al. Effect of pig-specific cytokines on mobilization of hematopoietic progenitor cells in pigs and on pig bone marrow engraftment in baboons. Xenotransplantation 1999 6 : 17 27.
27. Yamada K, Gianello PR, Ierino FL et al. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J Exp Med 1997 186 : 497 506.
28. Ivanoska D, Sun DC, Lunney JK. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics 1991 33 : 220 223.
29. Pescovitz MD, Lunney JK, Sachs DH. Murine anti-swine T4 and T8 monoclonal antibodies: distribution and effects on proliferative and cytotoxic T cells. J Immunol 1985 134 : 37 44.
30. Pescovitz MD, Lunney JK, Sachs DH. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol 1984 133 : 368 375.
31. Pescovitz MD, Hsu SM, Katz SI et al. Characterization of a porcine CD1-specific mAb that distinguishes CD4/CD8 double-positive thymic from peripheral T lymphocytes. Tissue Antigens 1990 35 : 151 156.
32. Sullivan JA, Oettinger HF, Sachs DH, Edge AS. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. J Immunol 1997 159 : 2318 2326.
33. Cosimi AB, Delmonico FL, Wright JK et al. Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody. Surgery 1990 108 : 406 413.
34. Gojo S, Harper D, Down J, Awwad M, Cooper DK. Differential expression of Galalpha1,3Gal epitopes on fetal and adult porcine hematopoietic cells. Xenotransplantation 2002 9 : 297 300.
35. Horner BM, Cina RA, Wikiel KJ et al. Predictors of organ allograft tolerance following hematopoietic cell transplantation. Am J Transplant 2006 6 : 2894 2902.