Prostaglandin E2's new trick: "Decider" of differential alveolar cell life and death

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 1, 2010, Pages 2-3

  Horowitz, Jeffrey C ^a   Peters Golden, Marc ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CYCLOOXYGENASE 2; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; PROSTANOID RECEPTOR 2; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

APOPTOSIS; CELL ACTIVATION; CELL ACTIVITY; CELL DEATH; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; EDITORIAL; ENZYME INHIBITION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROGENESIS; FIBROSING ALVEOLITIS; HUMAN; LUNG ALVEOLUS CELL; MESENCHYME CELL; MYOFIBROBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; WOUND HEALING; FIBROBLAST; INTERSTITIAL LUNG DISEASE; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY;

APOPTOSIS; DINOPROSTONE; FIBROBLASTS; HUMANS; LUNG DISEASES, INTERSTITIAL;

EID: 77955908559     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201002-0239ED     Document Type: Editorial

References (16)

1. 2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis. Am J Resp Crit Care Med 2010;182:73-82.
2. 2 induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J 2009;23:4317-4326.
3. Desmouliere A, Badid C, Bochaton-Piallat ML, Gabbiani G. Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury. Int J Biochem Cell Biol 1997;29:19-30.
4. Thannickal VJ, Horowitz JC. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006;3:350-356.
5. Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitriou JM, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA. Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis. J Pathol 2004;202:486-495.
6. Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A, Selman M. Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol 1998;275:L1192-L1199.
7. Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ. Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal 2007;19:761-771.
8. Marchand-Adam S, Marchal J, Cohen M, Soler P, Gerard B, Castier Y, Leseche G, Valeyre D, Mal H, Aubier M, et al. Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003;168:1156-1161.
9. Borok Z, Gillissen A, Buhl R, Hoyt R, Hubbard R, Ozaki T, Rennard S, Crystal R. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am Rev Respir Dis 1991;144:1080-1084.
10. 2 and to express cyclooxygenase-2. J Clin Invest 1995;95:1861-1868.
11. 2 production. Am J Pathol 2004;165:1663-1676.
12. 2. J Immunol 2005;174:5644-5649.
13. Huang SK, Peters-Golden M. Eicosanoid lipid mediators in fibrotic lung diseases: ready for prime time? Chest 2008;133:1442-1450.
14. Tessner TG, Muhale F, Riehl TE, Anant S, Stenson WF. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J Clin Invest 2004;114:1676-1685. (Pubitemid 40385559)
15. Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci USA 2003;100:8921-8926.
16. Matsumoto K, Okazaki H, Nakamura T. Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. J Biochem 1995;117:458-464.