Osteogenic properties of human dental pulp stem cells

Journal of Biological Regulators and Homeostatic Agents

Volumn 24, Issue 2, 2010, Pages 167-175

  Mori, Giorgio ^a   Centonze, M ^b   Brunetti, G ^b   Ballini, A ^b   Oranger, A ^b   Mori, C ^b   Lo Muzio, L ^c,d   Tete S ^e   Ciccolella, F ^b   Colucci, S ^b   Grano, M ^b   Grassi, F R ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^c Medical School   (Italy)

^d REFERRAL CANCER CENTER OF BASILICATA   (Italy)

^e Department of Oral Science   (Italy)

Author keywords

Dental pulp; DPSC; Osteoblast differentiation; Stem cell

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN; GROWTH FACTOR; INSULIN GROWTH FACTOR BINDING PROTEIN 5; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; PRIMER DNA; PROTEIN C JUN; RUNX2 PROTEIN, HUMAN; SOMATOMEDIN BINDING PROTEIN 5;

ARTICLE; BONE REGENERATION; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOLAR TOOTH; MORPHOGENESIS; OSTEOBLAST; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TOOTH PULP; TOOTH PULP STEM CELL; WESTERN BLOTTING; ADULT; BONE DEVELOPMENT; CYTOLOGY; GENETICS; KINETICS; METABOLISM; PHYSIOLOGY;

ADULT; ALKALINE PHOSPHATASE; CELL DIFFERENTIATION; COLLAGEN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DENTAL PULP; DNA PRIMERS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; KINETICS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPONTIN; PROTO-ONCOGENE PROTEINS C-JUN; STEM CELLS; YOUNG ADULT;

EID: 77955904363     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000; 97: 13625-30.
2. Iohara K, Zheng L, Ito M, Tomokiyo A, Matsushita K, Nakashima M. Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 2006; 24:2493-503.
3. Luan X, Ito Y, Dangaria S, Diekwisch TG. Dental follicle progenitor cell heterogeneity in the developing mouse periodontium. Stem Cells Dev 2006; 15:595-608.
4. Yang X, J van den Dolder, Walboomers XF, Zhang W, Bian Z, Fan M, Jansen JA. The odontogenic potential of STRO-1 sorted rat dental pulp stem cells in vitro. J Tissue Eng Regen Med 2007; 1:66-73.
5. Sloan AJ, Smith AJ. Stem cells and the dental pulp: potential roles in dentine regeneration and repair. Oral Dis 2007; 13:151-57.
6. Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs those from ' other sources: their biology and role in regenerative medicine. J Dent Res 2009; 88:792-806.
7. Ballini A, De Frenza G, Cantore S, Papa F, Grano M, Mastrangelo F, Tetè S, Grassi FR. In vitro stem cell cultures from human dental pulp and periodontal ligament: new prospects in dentistry. Int J Immunopathol Pharmacol 2007; 20:9-16.
8. Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH, Longaker MT, Shi S. Craniofacial tissue engineering by stem cells. J Dent Res 2006; 85:966-79.
9. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001; 19:180-92.
10. Bianco P, Gehron Robey P. Marrow stromal stem cells. J Clin Invest 2000; 105:1663-8.
11. Petersen B, Shupe T. Location is everything: the liver stem cell niche. Hepatology 2008; 47:1810-2.
12. Poulsom R, Alison MR, Cook T, Jeffery R, Ryan E, Forbes SJ, Hunt T, Wyles S, Wright NA. Bone marrow stem cells contribute to healing of the kidney. J Am Soc Nephrol 2003; 14(S)1:48-54.
13. Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001; 98:10344-9.
14. Mezey E, Chandross KJ. Bone marrow: a possible alternative source of cells in the adult nervous system. Eur J Pharmacol 2000; 405:297-302.
15. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into non-human primates. Blood 2003; 101:2999-3001.
16. Le Blanc K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003; 5: 485-9.
17. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103:4619-21.
18. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105:1815-22.
19. Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005; 11:389-98.
20. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, Ringden O. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-41.
21. Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006; 81:1390-97.
22. Pierdomenico L, Bonsi L, Calvitti M, et al. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation 2005; 80:836-42.
23. Vaananen HK. Mesenchymal stem cells. Annals of medicine 2005; 37:469-79.
24. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S. Stem cell properties of human dental pulp stem cells. J Dent Res 2002; 81:531-5.
25. Otaki S, Ueshima S, Shiraishi K, Sugiyama K, Hamada S, Yorimoto M, Matsuo O. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biol Int 2007; 31: 1191-7.
26. Huang G, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan R, Shi S. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 2010; 16:605-15.
27. Takeyasu M, Nozaki T, Watanabe M, et al. In vitro osteogenic differentiation potential of dental pulp stem cells. J Oral Tissue Engin 2004; 2:25-30.
28. Laino G, d'Aquino R, Graziano A, Lanza V, Carinci F, Naro F, Pirozzi G, Papaccio G. A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). J Bone Miner Res 2005; 20:1394-402.
29. Kawazoe Y, Katoh S, Onodera Y, Kohgo T, Shindoh M, Shiba T. Activation of the FGF signaling pathway subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate. Int J Biol Sci 2008; 4:37-47.
30. Suguro H, Asano M, Kaneko Y, Omagari D, Ogiso B, Moro I, Komiyama K. Characterization of human dental pulp-derived cell lines. Int Endod J 2008; 41: 609-16.
31. Kuo MY, Lan WH, Lin SK, Tsai KS, Hahn LJ. Collagen gene expression in human dental pulp cell cultures. Arch Oral Biol 1992; 37:945-52.
32. D'Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De Rosa A, Papaccio G. Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation. Cell Death Differ 2007; 14: 1162-71.
33. D'Aquino R, Papaccio G, Laino G, Graziano A. Dental pulp stem cells: a promising tool for bone regeneration. Stem Cell Rev 2008; 4:21-6.
34. Kenner L, Hoebertz A, Beil T, et al. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 2004; 164:613-23.
35. Mohan S, Baylink DJ. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol 2002; 175: 19-31.
36. Shi S, Robey PG, Gronthos S. Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone 2001; 29:532-39.
37. Ducy P. Cbfal: a molecular switch in osteoblast biology. Dev Dyn 2000; 219:461-71.