메뉴 건너뛰기




Volumn 10, Issue 3, 2010, Pages 169-176

First-line therapy for chronic myeloid leukemia: New horizons and an update

Author keywords

Bosutinib; Dasatinib; Imatinib; Nilotinib

Indexed keywords

BCR ABL PROTEIN; BOSUTINIB; CYTARABINE; DASATINIB; IMATINIB; INTERFERON; NILOTINIB; PEGINTERFERON; ANAGRELIDE; BAFETINIB; DANUSERTIB; HOMOHARRINGTONINE; HYDROXYUREA; LONAFARNIB; PONATINIB; SORAFENIB; TIPIFARNIB; XL 228; 4 METHYL N (3 (4 METHYLIMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL) 3 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YL)AMINO)BENZAMIDE; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; ANTINEOPLASTIC AGENT; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

EID: 77955898556     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.3816/CLML.2010.n.026     Document Type: Review
Times cited : (13)

References (71)
  • 1
    • 68549097002 scopus 로고    scopus 로고
    • International Randomized Study of Interferon Versus STI571 (IRIS) 7-year follow-up: Sustained survival, low rate of transformation and increased rate of major molecular response in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib
    • abstract 186
    • O'Brien SG, Guilhot F, Goldman JM, et al. International Randomized Study of Interferon Versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response in patients with newly diagnosed chronic myeloid leukemia in chronic phase treated with imatinib. Blood 2008; 112(suppl):76 (abstract 186).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 76
    • O'brien, S.G.1    Guilhot, F.2    Goldman, J.M.3
  • 2
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355:2408-2417
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'brien, S.G.3
  • 3
    • 49149111543 scopus 로고    scopus 로고
    • Imatinib for newly diagnosed patients with chronic myeloid leukemia: Incidence of sustained responses in an intention-to-treat analysis
    • de Lavallade H, Apperley JF, Khorashad JS, et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol 2008; 26:3358-3363
    • (2008) J Clin Oncol , vol.26 , pp. 3358-3363
    • De Lavallade, H.1    Apperley, J.F.2    Khorashad, J.S.3
  • 4
    • 54049130762 scopus 로고    scopus 로고
    • A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials
    • Lucas CM, Wang L, Austin GM, et al. A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials. Leukemia 2008; 22:1963-1966
    • (2008) Leukemia , vol.22 , pp. 1963-1966
    • Lucas, C.M.1    Wang, L.2    Austin, G.M.3
  • 5
    • 0021336851 scopus 로고
    • Prognostic discrimination in "good-risk" chronic granulocytic leukemia
    • Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood 1984; 63:789-799
    • (1984) Blood , vol.63 , pp. 789-799
    • Sokal, J.E.1    Cox, E.B.2    Baccarani, M.3
  • 6
    • 59549084574 scopus 로고    scopus 로고
    • The long-term durability of cytogenetic responses in patients with accelerated phase chronic myeloid leukemia treated with imatinib 600 mg: The GIMEMA CML Working Party experience after a 7-year follow-up
    • Palandri F, Castagnetti F, Alimena G, et al. The long-term durability of cytogenetic responses in patients with accelerated phase chronic myeloid leukemia treated with imatinib 600 mg: the GIMEMA CML Working Party experience after a 7-year follow-up. Haematologica 2009; 94:205-212
    • (2009) Haematologica , vol.94 , pp. 205-212
    • Palandri, F.1    Castagnetti, F.2    Alimena, G.3
  • 7
    • 66049150292 scopus 로고    scopus 로고
    • Sustained durability of responses and improved progression-free and overall survival with imatinib treatment for accelerated phase and blast crisis chronic myeloid leukemia: Long-term follow-up of the STI571 0102 and 0109 trials
    • Silver RT, Cortes J, Waltzman R, et al. Sustained durability of responses and improved progression-free and overall survival with imatinib treatment for accelerated phase and blast crisis chronic myeloid leukemia: long-term follow-up of the STI571 0102 and 0109 trials. Haematologica 2009; 94:743-744
    • (2009) Haematologica , vol.94 , pp. 743-744
    • Silver, R.T.1    Cortes, J.2    Waltzman, R.3
  • 8
    • 57349124075 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: Outcome of the patients alive after a 6-year follow-up
    • Palandri F, Castagnetti F, Testoni N, et al. Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: outcome of the patients alive after a 6-year follow-up. Haematologica 2008; 93:1792-1796
    • (2008) Haematologica , vol.93 , pp. 1792-1796
    • Palandri, F.1    Castagnetti, F.2    Testoni, N.3
  • 9
    • 39049161669 scopus 로고    scopus 로고
    • Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia: Need for new response definitions?
    • Kantarjian H, O'Brien S, Shan J, et al. Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia: need for new response definitions? Cancer 2008; 112:837-845
    • (2008) Cancer , vol.112 , pp. 837-845
    • Kantarjian, H.1    O'brien, S.2    Shan, J.3
  • 10
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349:1423-1432
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 11
    • 58149396984 scopus 로고    scopus 로고
    • European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
    • Marin D, Milojkovic D, Olavarria E, et al. European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 2008; 112:4437-4444
    • (2008) Blood , vol.112 , pp. 4437-4444
    • Marin, D.1    Milojkovic, D.2    Olavarria, E.3
  • 12
    • 0141613844 scopus 로고    scopus 로고
    • Molecular monitoring of response to imatinib (Glivec) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission
    • Paschka P, Müller MC, Merx K, et al. Molecular monitoring of response to imatinib (Glivec) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission. Leukemia 2003; 17:1687-1694
    • (2003) Leukemia , vol.17 , pp. 1687-1694
    • Paschka, P.1    Müller, M.C.2    Merx, K.3
  • 14
    • 33744463354 scopus 로고    scopus 로고
    • BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML
    • Press RD, Love Z, Tronnes AA, et al. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML. Blood 2006; 107:4250-4256
    • (2006) Blood , vol.107 , pp. 4250-4256
    • Press, R.D.1    Love, Z.2    Tronnes, A.A.3
  • 15
    • 33744798191 scopus 로고    scopus 로고
    • Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients
    • Iacobucci I, Saglio G, Rosti G, et al. Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients. Clin Cancer Res 2006; 12:3037-3042
    • (2006) Clin Cancer Res , vol.12 , pp. 3037-3042
    • Iacobucci, I.1    Saglio, G.2    Rosti, G.3
  • 16
    • 61349154989 scopus 로고    scopus 로고
    • Treatment of Philadelphia-positive chronic myeloid leukemia with imatinib: Importance of a stable molecular response
    • Palandri F, Iacobucci I, Soverini S, et al. Treatment of Philadelphia-positive chronic myeloid leukemia with imatinib: importance of a stable molecular response. Clin Cancer Res 2009; 15:1059-1063
    • (2009) Clin Cancer Res , vol.15 , pp. 1059-1063
    • Palandri, F.1    Iacobucci, I.2    Soverini, S.3
  • 17
    • 37249016890 scopus 로고    scopus 로고
    • BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years and approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict sensitivity criteria
    • Branford S, Seymour JF, Grigg A, et al. BCR-ABL messenger RNA levels continue to decline in patients with chronic phase chronic myeloid leukemia treated with imatinib for more than 5 years and approximately half of all first-line treated patients have stable undetectable BCR-ABL using strict sensitivity criteria. Clin Cancer Res 2007; 13:7080-7085
    • (2007) Clin Cancer Res , vol.13 , pp. 7080-7085
    • Branford, S.1    Seymour, J.F.2    Grigg, A.3
  • 18
    • 35948937212 scopus 로고    scopus 로고
    • A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response
    • Press RD, Galderisi C, Yang R, et al. A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response. Clin Cancer Res 2007; 13:6136-6143
    • (2007) Clin Cancer Res , vol.13 , pp. 6136-6143
    • Press, R.D.1    Galderisi, C.2    Yang, R.3
  • 19
    • 9144264829 scopus 로고    scopus 로고
    • Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • Branford S, Rudzki Z, Harper A, et al. Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia 2003; 17:2401-2409
    • (2003) Leukemia , vol.17 , pp. 2401-2409
    • Branford, S.1    Rudzki, Z.2    Harper, A.3
  • 20
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • Wang L, Pearson K, Ferguson JE, et al. The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br J Haematol 2003; 120:990-999
    • (2003) Br J Haematol , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3
  • 21
    • 20144388183 scopus 로고    scopus 로고
    • Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5-year follow-up
    • Lahaye T, Riehm B, Berger U, et al. Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up. Cancer 2005; 103:1659-1669
    • (2005) Cancer , vol.103 , pp. 1659-1669
    • Lahaye, T.1    Riehm, B.2    Berger, U.3
  • 22
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23:1054-1061
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'brien, S.G.2    Guilhot, F.3
  • 23
    • 73349122639 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
    • Baccarani M, Cortes J, Pane F, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009; 27:6041-6051
    • (2009) J Clin Oncol , vol.27 , pp. 6041-6051
    • Baccarani, M.1    Cortes, J.2    Pane, F.3
  • 24
    • 62649138065 scopus 로고    scopus 로고
    • Time to complete cytogenetic response does not affect long-term outcomes for patients on imatinib therapy
    • abstract 27
    • Guilhot F, Larson RA, O'Brien SG, et al. Time to complete cytogenetic response does not affect long-term outcomes for patients on imatinib therapy. Blood 2007; 110(suppl):16a (abstract 27).
    • (2007) Blood , vol.110 , Issue.SUPPL.
    • Guilhot, F.1    Larson, R.A.2    O'brien, S.G.3
  • 25
    • 67650587143 scopus 로고    scopus 로고
    • Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy
    • Quintas-Cardama A, Kantarjian H, Jones D, et al. Delayed achievement of cytogenetic and molecular response is associated with increased risk of progression among patients with chronic myeloid leukemia in early chronic phase receiving high-dose or standard-dose imatinib therapy. Blood 2009; 113:6315-6321
    • (2009) Blood , vol.113 , pp. 6315-6321
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3
  • 26
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102:276-283
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 27
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(varphi) -LMC Group)
    • Nicolini FE, Corm S, Le QH, et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(varphi)-LMC Group). Leukemia 2006; 20:1061-1066
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm Le, S.Q.H.2
  • 28
    • 40849105148 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib
    • Ernst T, Erben P, Muller MC, et al. Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib. Haematologica 2008; 93:186-192
    • (2008) Haematologica , vol.93 , pp. 186-192
    • Ernst, T.1    Erben, P.2    Muller, M.C.3
  • 29
    • 54349089682 scopus 로고    scopus 로고
    • Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression
    • Khorashad JS, de Lavallade H, Apperley JF, et al. Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression. J Clin Oncol 2008; 26:4806-4813
    • (2008) J Clin Oncol , vol.26 , pp. 4806-4813
    • Khorashad, J.S.1    De Lavallade, H.2    Apperley, J.F.3
  • 31
    • 33846495006 scopus 로고    scopus 로고
    • The prognosis impact of BCR-ABL P-loop mutations: Worse or not worse?
    • Nicolini FE, Corm S, Le QH, et al. The prognosis impact of BCR-ABL P-loop mutations: worse or not worse? Leukemia 2007; 21:193-194
    • (2007) Leukemia , vol.21 , pp. 193-194
    • Nicolini, F.E.1    Corm, S.2    Le, Q.H.3
  • 32
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E, Kantarjian H, Jones D, et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 2008; 112:53-55
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 33
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 34
    • 66549108340 scopus 로고    scopus 로고
    • Comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of high-risk. Philadelphia-positive chronic myeloid leukemia: A European LeukemiaNet Study
    • Baccarani M, Rosti G, Castagnetti F, et al. Comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of high-risk, Philadelphia- positive chronic myeloid leukemia: a European LeukemiaNet Study. Blood 2009; 113:4497-4504
    • (2009) Blood , vol.113 , pp. 4497-4504
    • Baccarani, M.1    Rosti, G.2    Castagnetti, F.3
  • 35
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65:4500-4505
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 36
    • 55949102580 scopus 로고    scopus 로고
    • Dasatinib pharmacokinetics and exposure-response (E-R): Relationship to safety and efficacy in patients with chronic myeloid leukemia
    • abstract 3590
    • Wang X, Hochhaus A, Kantarjian HM, et al. Dasatinib pharmacokinetics and exposure-response (E-R): relationship to safety and efficacy in patients with chronic myeloid leukemia. J Clin Oncol 2008; 26(suppl):175s (abstract 3590).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Wang, X.1    Hochhaus, A.2    Kantarjian, H.M.3
  • 37
    • 1542608328 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of imatinib in a phase i trial with chronic myeloid leukemia patients
    • Peng B, Hayes M, Resta D, et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004; 22:935-942
    • (2004) J Clin Oncol , vol.22 , pp. 935-942
    • Peng, B.1    Hayes, M.2    Resta, D.3
  • 38
    • 34147174980 scopus 로고    scopus 로고
    • Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    • Picard S, Titier K, Etienne G, et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 2007; 109:3496-3499
    • (2007) Blood , vol.109 , pp. 3496-3499
    • Picard, S.1    Titier, K.2    Etienne, G.3
  • 39
    • 43249083718 scopus 로고    scopus 로고
    • Imatinib pharmacokinetics and its correlation with response and safety in chronic phase chronic myeloid leukemia: A subanalysis of the IRIS Study
    • Larson RA, Druker BJ, Guilhot F, et al. Imatinib pharmacokinetics and its correlation with response and safety in chronic phase chronic myeloid leukemia: a subanalysis of the IRIS Study. Blood 2008; 111:4022-4028
    • (2008) Blood , vol.111 , pp. 4022-4028
    • Larson, R.A.1    Druker, B.J.2    Guilhot, F.3
  • 40
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005; 7:129-141
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 42
    • 60049093162 scopus 로고    scopus 로고
    • Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: A 2-year update of the START-C Study
    • abstract 0934
    • Cervantes F, Baccarani M, Lipton J, et al. Dasatinib long-term efficacy in patients with chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to imatinib: a 2-year update of the START-C Study. Haematologica 2008; 93(suppl 1):372 (abstract 0934).
    • (2008) Haematologica , vol.93 , Issue.SUPPL. 1 , pp. 372
    • Cervantes, F.1    Baccarani, M.2    Lipton, J.3
  • 43
    • 74849123813 scopus 로고    scopus 로고
    • Nilotinib in chronic myeloid leukemia patients in chronic phase with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study
    • abstract 0627
    • Kantarjian H, Giles F, Bhalla K, et al. Nilotinib in chronic myeloid leukemia patients in chronic phase with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study. Haematologica 2009; 94(suppl 2):254 (abstract 0627).
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 254
    • Kantarjian, H.1    Giles, F.2    Bhalla, K.3
  • 44
    • 49249121723 scopus 로고    scopus 로고
    • Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia
    • Shah NP, Kantarjian HM, Kim DW, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008; 26:3204-3212
    • (2008) J Clin Oncol , vol.26 , pp. 3204-3212
    • Shah, N.P.1    Kantarjian, H.M.2    Kim, D.W.3
  • 45
    • 85031334054 scopus 로고    scopus 로고
    • Tasigna (nilotinib) [US prescribing information]: Basel, Switzerland: Novartis; August 2009
    • Tasigna (nilotinib) [US prescribing information]: Basel, Switzerland: Novartis; August 2009.
  • 46
    • 85031344218 scopus 로고    scopus 로고
    • Sprycel (dasatinib) [US prescribing information]: New York, New York: Bristol-Myers Squibb; May 2009
    • Sprycel (dasatinib) [US prescribing information]: New York, New York: Bristol-Myers Squibb; May 2009.
  • 47
    • 33845806858 scopus 로고    scopus 로고
    • In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
    • Puttini M, Coluccia AM, Boschelli F, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res 2006; 66:11314-11322
    • (2006) Cancer Res , vol.66 , pp. 11314-11322
    • Puttini, M.1    Coluccia, A.M.2    Boschelli, F.3
  • 48
    • 65649108082 scopus 로고    scopus 로고
    • Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase Ph+ chronic myelogenous leukemia with resistance or intolerance to imatinib
    • abstract 1098
    • Cortes J, Kantarjian HM, Kim D, et al. Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase Ph+ chronic myelogenous leukemia with resistance or intolerance to imatinib. Blood 2008; 112 (suppl):401 (abstract 1098).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 401
    • Cortes, J.1    Kantarjian, H.M.2    Kim, D.3
  • 49
    • 67651162381 scopus 로고    scopus 로고
    • Novel agents in CML therapy: Tyrosine kinase inhibitors and beyond
    • Melo JV, Chuah C. Novel agents in CML therapy: tyrosine kinase inhibitors and beyond. Hematol Am Soc Hematol Educ Program 2008; 2008:427-435
    • (2008) Hematol Am Soc Hematol Educ Program 2008 , pp. 427-435
    • Melo, J.V.1    Chuah, C.2
  • 50
    • 43749113363 scopus 로고    scopus 로고
    • Experimental non-ATP-competitive therapies for chronic myelogenous leukemia
    • DOI 10.1038/leu.2008.47, PII LEU200847
    • Quintas-Cardama A. Experimental non-ATP-competitive therapies for chronic myelogenous leukemia. Leukemia 2008; 22:932-940 (Pubitemid 351689874)
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 932-940
    • Quintas-Cardama, A.1
  • 51
    • 75749129911 scopus 로고    scopus 로고
    • Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia
    • Cortes JE, Jones D, O'Brien S, et al. Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. J Clin Oncol 2010; 28:398-404.
    • (2010) J Clin Oncol , vol.28 , pp. 398-404
    • Cortes, J.E.1    Jones, D.2    O'brien, S.3
  • 52
    • 75749090051 scopus 로고    scopus 로고
    • Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase
    • Cortes JE, Jones D, O'Brien S, et al. Nilotinib as front-line treatment for patients with chronic myeloid leukemia in early chronic phase. J Clin Oncol 2010; 28:392-397
    • (2010) J Clin Oncol , vol.28 , pp. 392-397
    • Cortes, J.E.1    Jones, D.2    O'brien, S.3
  • 53
    • 73949145209 scopus 로고    scopus 로고
    • Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia
    • Rosti G, Palandri F, Castagnetti F, et al. Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia. Blood 2009; 114:4933-4938
    • (2009) Blood , vol.114 , pp. 4933-4938
    • Rosti, G.1    Palandri, F.2    Castagnetti, F.3
  • 54
    • 77949715479 scopus 로고    scopus 로고
    • Nilotinib demonstrates superior efficacy compared with imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase: Results from the international randomized phase III ENESTnd trial
    • abstract LBA1
    • Saglio G, Kim DW, Issaragrisil S, et al. Nilotinib demonstrates superior efficacy compared with imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase: results from the international randomized phase III ENESTnd trial. Blood 2009; 114(suppl): (abstract LBA1).
    • (2009) Blood , vol.114 , Issue.SUPPL.
    • Saglio, G.1    Kim, D.W.2    Issaragrisil, S.3
  • 56
    • 70350442594 scopus 로고    scopus 로고
    • High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: High rates of rapid cytogenetic and molecular responses
    • Cortes JE, Kantarjian HM, Goldberg SL, et al. High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses. J Clin Oncol 2009; 27:4754-4759
    • (2009) J Clin Oncol , vol.27 , pp. 4754-4759
    • Cortes, J.E.1    Kantarjian, H.M.2    Goldberg, S.L.3
  • 57
    • 65349140717 scopus 로고    scopus 로고
    • Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: A phase 2 trial of the GIMEMA CML Working Party
    • Castagnetti F, Palandri F, Amabile M, et al. Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working Party. Blood 2009; 113:3428-3434
    • (2009) Blood , vol.113 , pp. 3428-3434
    • Castagnetti, F.1    Palandri, F.2    Amabile, M.3
  • 58
    • 65649138749 scopus 로고    scopus 로고
    • A phase III, randomized, open-label study of 400 mg versus 800 mg of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular endpoints: 1-year results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) study
    • abstract 335
    • Cortes J, Baccarani M, Guilhot F, et al. A phase III, randomized, open-label study of 400 mg versus 800 mg of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular endpoints: 1-year results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) study. Blood 2008; 112(suppl):130 (abstract 335).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 130
    • Cortes, J.1    Baccarani, M.2    Guilhot, F.3
  • 59
    • 77953723830 scopus 로고    scopus 로고
    • 24 months update of the TOPS Study: A phase III, randomized, open-label study of 400 mg/d versus 800 mg/d of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase
    • abstract 337
    • Baccarani M, Druker BJ, Cortes-Franco J, et al. 24 months update of the TOPS Study: a phase III, randomized, open-label study of 400 mg/d versus 800 mg/d of imatinib mesylate in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase. Blood 2009; 114(suppl):142-143 (abstract 337).
    • (2009) Blood , vol.114 , Issue.SUPPL. , pp. 142-143
    • Baccarani, M.1    Druker, B.J.2    Cortes-Franco, J.3
  • 60
    • 58149160055 scopus 로고    scopus 로고
    • Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy
    • Hughes TP, Branford S, White DL, et al. Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy. Blood 2008; 112:3965-3973
    • (2008) Blood , vol.112 , pp. 3965-3973
    • Hughes, T.P.1    Branford, S.2    White, D.L.3
  • 61
    • 64049099666 scopus 로고    scopus 로고
    • Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy
    • Jabbour E, Kantarjian HM, Jones D, et al. Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia after cytogenetic failure on standard-dose imatinib therapy. Blood 2009; 113:2154-2160
    • (2009) Blood , vol.113 , pp. 2154-2160
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3
  • 62
    • 60049092698 scopus 로고    scopus 로고
    • Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase
    • Kantarjian HM, Larson RA, Guilhot F, et al. Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase. Cancer 2009; 115:551-560
    • (2009) Cancer , vol.115 , pp. 551-560
    • Kantarjian, H.M.1    Larson, R.A.2    Guilhot, F.3
  • 63
    • 67349262464 scopus 로고    scopus 로고
    • Imatinib dose escalation for chronic phase-chronic myelogenous leukaemia patients in primary suboptimal response to imatinib 400 mg daily standard therapy
    • Rea D, Etienne G, Corm S, et al. Imatinib dose escalation for chronic phase-chronic myelogenous leukaemia patients in primary suboptimal response to imatinib 400 mg daily standard therapy. Leukemia 2009; 23:1193-1196
    • (2009) Leukemia , vol.23 , pp. 1193-1196
    • Rea, D.1    Etienne, G.2    Corm, S.3
  • 64
    • 71849109215 scopus 로고    scopus 로고
    • Imatinib pharmacokinetic exposure and its correlation with clinical outcome in patients with chronic-phase chronic myeloid leukemia for 400 mg and 800 mg daily doses (Tyrosine Kinase Dose Optimization Study [TOPS])
    • abstract 447
    • Guilhot F, Hughes TP, Cortes J, et al. Imatinib pharmacokinetic exposure and its correlation with clinical outcome in patients with chronic-phase chronic myeloid leukemia for 400 mg and 800 mg daily doses (Tyrosine Kinase Dose Optimization Study [TOPS]). Blood 2008; 112(suppl):170 (abstract 447).
    • (2008) Blood , vol.112 , Issue.SUPPL. , pp. 170
    • Guilhot, F.1    Hughes, T.P.2    Cortes, J.3
  • 65
    • 57049115901 scopus 로고    scopus 로고
    • Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough imatinib plasma levels
    • Forrest DL, Trainor S, Brinkman RR, et al. Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough imatinib plasma levels. Leuk Res 2009; 33:271-275
    • (2009) Leuk Res , vol.33 , pp. 271-275
    • Forrest, D.L.1    Trainor, S.2    Brinkman, R.R.3
  • 67
    • 10244257546 scopus 로고    scopus 로고
    • Imatinib and pegylated human recombinant interferon-alpha2b in early chronic-phase chronic myeloid leukemia
    • Baccarani M, Martinelli G, Rosti G, et al. Imatinib and pegylated human recombinant interferon-alpha2b in early chronic-phase chronic myeloid leukemia. Blood 2004; 104:4245-4251
    • (2004) Blood , vol.104 , pp. 4245-4251
    • Baccarani, M.1    Martinelli, G.2    Rosti, G.3
  • 68
    • 43449118108 scopus 로고    scopus 로고
    • Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5-year outcome
    • Palandri F, Iacobucci I, Castagnetti F, et al. Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5-year outcome. Haematologica 2008; 93:770-774
    • (2008) Haematologica , vol.93 , pp. 770-774
    • Palandri, F.1    Iacobucci, I.2    Castagnetti, F.3
  • 69
    • 77956996657 scopus 로고    scopus 로고
    • Molecular responses of the SPIRIT phase III trial of the French CML group comparing imatinib mg to higher dose imatinib or combination with interferon or cytarabine for the treatment of newly diagnosed chronic phase chronic myeloid leukaemia patients
    • abstract 1093
    • Rousselot P, Preudhomme C, Guilhot J, et al. Molecular responses of the SPIRIT phase III trial of the French CML group comparing imatinib mg to higher dose imatinib or combination with interferon or cytarabine for the treatment of newly diagnosed chronic phase chronic myeloid leukaemia patients. Haematologica 2009; 94(suppl 2):441 (abstract 1093).
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 441
    • Rousselot, P.1    Preudhomme, C.2    Guilhot, J.3
  • 70
    • 77953241114 scopus 로고    scopus 로고
    • Randomized comparison of imatinib 800 mg vs. imatinib 400 mg ± IFN in newly diagnosed BCR/ABL positive chronic phase CML: Analysis of molecular remission at 12 months; The German CML-Study IV
    • abstract 339
    • Hehlmann R, Jung-Munkwitz S, Lauseker M, et al. Randomized comparison of imatinib 800 mg vs. imatinib 400 mg ± IFN in newly diagnosed BCR/ABL positive chronic phase CML: analysis of molecular remission at 12 months; the German CML-Study IV. Blood 2009; 114(suppl):143-144 (abstract 339).
    • (2009) Blood , vol.114 , Issue.SUPPL. , pp. 143-144
    • Hehlmann, R.1    Jung-Munkwitz, S.2    Lauseker, M.3
  • 71
    • 41949083909 scopus 로고    scopus 로고
    • Dose-finding study of imatinib in combination with intravenous cytarabine: Feasibility in newly diagnosed patients with chronic myeloid leukemia
    • Deenik W, van der HB, Verhoef GE, et al. Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia. Blood 2008; 111:2581-2588
    • (2008) Blood , vol.111 , pp. 2581-2588
    • Deenik, W.1    Van Der, H.B.2    Verhoef, G.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.