Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: Structure activity study

Amino Acids

Volumn 38, Issue 5, 2010, Pages 1549-1559

  Magafa, Vassiliki ^a   Borovičková, Lenka ^b   Slaninová, Jiřina ^b   Cordopatis, Paul ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Binding affinity; Biological activity; Oxytocin antagonists; Position 9; Unnatural amino acids

Indexed keywords

AMINO ACID; DEMOXYTOCIN[2 DEXTRO O ETHYLTYROSINE]; OXYTOCIN; OXYTOCIN DERIVATIVE; OXYTOCIN RECEPTOR; OXYTOCIN[1 BETA,BETA DIMETHYLCYSTEINE 2 DEXTRO 1 NAPHTHYLALANINE 9 ALPHA AMINOISOBUTYRIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE 9 (3 PYRIDYLALANINE)]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE 9 ALPHA AMINOISOBUTYRIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE 9 BETA (2 THIENYL)ALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE 9 DEXTRO 3 PYRIDYLALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE 9 DEXTRO BETA (2 THIENYL)ALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1 NAPHTHYLALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID 9 ALPHA AMINOISOBUTYRIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 6 BETA,BETA DIMETHYLCYSTEINE 9 ALPHA AMINOISOBUTYRIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 6 BETA,BETA DIMETHYLCYSTEINE 9 DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 (3 PYRIDYLALANINE)]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 ALPHA AMINOISOBUTYRIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 BETA (2 THIENYL)ALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 DEXTRO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 DEXTRO 3 PYRIDYLALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 DEXTRO BETA (2 THIENYL)ALANINE]; OXYTOCIN[1 DEAMINO 2 DEXTRO O ETHYLTYROSINE 9 DIETHYLGLYCINE]; OXYTOCIN[1 DEAMINO 9 (3 PYRIDYLALANINE)]; OXYTOCIN[1 DEAMINO 9 BETA (2 THIENYL)ALANINE]; OXYTOCIN[1 DEAMINO 9 DEXTRO 3 PYRIDYLALANINE]; OXYTOCIN[9 (3 PYRIDYLALANINE)]; OXYTOCIN[9 BETA (2 THIENYL)ALANINE]; OXYTOCIN[9 DEXTRO 3 PYRIDYLALANINE]; UNCLASSIFIED DRUG; UTEROTONIC AGENT; DRUG DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; RECEPTOR AFFINITY; SMOOTH MUSCLE TONE; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS;

RATTUS;

AMINO ACIDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; OXYTOCIN; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955891533     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0372-2     Document Type: Article

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