Lipoic acid nanoparticles: Effect of polymeric stabilizer on appetite suppression

Pharmazie

Volumn 65, Issue 8, 2010, Pages 580-584

  Park, Chul Ho ^a   Lee, Ki Up ^b   Park, Joong Yeol ^b   Koh, Eun Hee ^b   Kim, Hyoun Sik ^b   Lee, Jonghwi ^a  

^a Chung Ang University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROPYLCELLULOSE; NANOPARTICLE; POLOXAMER; POVIDONE; THIOCTIC ACID; ANOREXIGENIC AGENT; CELLULOSE; EXCIPIENT; POLYMER; POWDER;

ANIMAL EXPERIMENT; APPETITE; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG STABILITY; DRUG SYNTHESIS; FOOD INTAKE; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; SUSPENSION; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; C57BL MOUSE; DRUG EFFECTS; EATING; MEDICINAL CHEMISTRY; POWDER; SOLUBILITY;

ANIMALS; APPETITE DEPRESSANTS; BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EATING; EXCIPIENTS; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; POLYMERS; POVIDONE; POWDERS; SOLUBILITY; THIOCTIC ACID;

EID: 77955889165     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.0014     Document Type: Article

References (23)

1. Bernkop-Schnürch A (2005) Mucoadhesive polymers: strategies, achievements and future challenges. Adv Drug Deliv Rev 57: 1553-1555.
2. Biewenga GP, Haenen G, Bast A (1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29: 315-331.
3. Bilska A, Wlodek L (2005) Lipoic acid - the drug of the future? Pharmacol Rep 57: 570-577.
4. Breithaupt-Grogler K, Niebch G, Schneider E, Erb K, Hermann R, Blume HH, Schug BS, Belz GG (1999) Dose-proportionality of oral thioctic acid - coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci 8: 57-65.
5. Broman E, Khoo C, Taylor LS (2001) A comparison of alternative polymer excipients and processing methods for making solid dispersions of a poorly water soluble drug. Int J Pharm 222: 139-151.
6. Choi JY, Yoo JY, Kwak H-S, Uk Nam B, Lee J (2005) Role of polymeric stabilizers for drug nanocrystal dispersions. Current Appl Phys 5: 472-474.
7. deChasteigner S, Cave G, Fessi H, Devissaguet JP, Puisieux F (1996) Freeze-drying of itraconazole-loaded nanosphere suspensions: a feasibility study. Drug Devel Res 38: 116-124.
8. deChasteigner S, Fessi H, Cave G, Devissaguet JP, Puisieux F (1995) Gastrointestinal tolerance study of a freeze-dried oral dosage form of indomethacin-loaded nanocapsules. STP Pharma Sci 5: 242-246.
9. Fuchs J, Packer L, Zimmer G (1997) Lipoic acid in health and disease. In: Hermann R, Niebch G (eds) Biothiols, Pt A, pp. 340-347.
10. Fujiwara K, Okamuraikeda K, Motokawa Y (1995) Assay for protein lipoylation reaction. In: In: Hermann R, Niebch G (eds) Biothiols, Pt A, pp. 340-347.
11. Gao L, Zhang DR, Chen MH (2008) Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 10: 845-862.
12. Hermann R, Niebch G, Borbe HO, FiegerBuschges H, Ruus P, Nowak H, RiethmullerWinzen H, Peukert M, Blume H (1996) Enantioselective pharmacokinetics and bioavailability of different racemic alpha-lipoic acid formulations in healthy volunteers. Eur J Pharm Sci 4: 167-174.
13. Herrero-Vanrell R, Vicario M, de las Heras B, Rincon A, Molina-Martinez IT (2005) in vitro evaluation of solutions prepared from mucoadhesive polymers. Invest Ophthalmol Vis Sci 46: 2034.
14. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, et al. (2004) Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10: 727-733.
15. Kipp JE (2004) The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm 284: 109-122.
16. Möschwitzer J, Müller RH (2006) Spray coated pellets as carrier system for mucoadhesive drug nanocrystals. Eur J Pharm Biopharm 62: 282-287.
17. Ma XY, Padmalayam I, Cahoon S, Chakrabarti R, Pillarisetti S, Saxena U (2006) Lipoic acid prevents atherosclerosis lesion development in ApoE null mice. Diabetes 55: A497-A497.
18. Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I (1999) Comparison of the effect of [alpha]-lipoic acid and [alpha]-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med 27: 1114-1121.
19. Packer L, Tritschler HJ, Wessel K (1997) Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 22: 359-378.
20. Park CH, Kim AR, Yun HL, Lee J (2006) Ring opening and polymerization of alpha-lipoic acid. Polym-Korea 30: 357-361.
21. Park CH, Youn HR, Lee J, Lee KU, Park JY, Koh EH, Kim HS (2009) Improvedefficacyof appetite suppression by lipoic acid particles prepared by nanocomminution. Drug Devel Ind Pharm 35: 1305-1311.
22. Sudhakara Y, Kuotsua K, Bandyopadhyay AK (2006) Buccal bioadhesive drug delivery - A promising option for orally less efficient drugs. J Control Release 114: 15-40.
23. Strodter D, Lehmann E, Lehmann U, Tritschler HJ, Bretzel RG, Federlin K (1995) The influence of thioctic acid on metabolism and function of the diabetic heart Diabetes Res Clin Pract 29: 19-26.