Synthesis and evaluation of chitosan-graft-polyethylenimine as a gene vector

Pharmazie

Volumn 65, Issue 8, 2010, Pages 572-579

  Wang, X ^a   Yao, J ^a   Zhou, J P ^a   Lu, Y ^a   Wang, W ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN DERIVATIVE; CHITOSAN GRAFT POLYETHYLENIMINE; ENHANCED GREEN FLUORESCENT PROTEIN; PLASMID DNA; POLYETHYLENEIMINE; POLYETHYLENEIMINE DERIVATIVE; PROTEIN P53; UNCLASSIFIED DRUG; CHITOSAN; CHITOSAN-GRAFT-POLYETHYLENIMINE; DEOXYRIBONUCLEASE I; DNA; DRUG CARRIER; HEPARIN;

ARTICLE; CELL STRAIN HEPG2; COMPLEX FORMATION; CONTROLLED STUDY; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MOLECULAR STABILITY; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; CARBOHYDRATE ANALYSIS; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENE TRANSFER; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TOXICITY;

CARBOHYDRATE SEQUENCE; CELL LINE; CELL SURVIVAL; CHITOSAN; DEOXYRIBONUCLEASE I; DNA; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HEPARIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; POLYETHYLENEIMINE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSFECTION;

EID: 77955886709     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9422     Document Type: Article

References (22)

1. Bertschinger M, Backliwal G, Schertenleib A, Jordan M, Hacker DL, Wurm FM (2006) Disassembly of polyethylenimine-DNA particles in vitro: implications for polyethylenimine- mediated DNA delivery. J Control Release 116: 96-104. (Pubitemid 44792305)
2. Boeckle S, Wagner E (2006) Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems. AAPS J 8: E731-742.
3. Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A (2000) Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288: 627-629.
4. Dang JM, Leong KW (2006) Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 58: 487-499. (Pubitemid 43928168)
5. Dash PR, Read ML, Barrett LB, Wolfert MA, Seymour LW (1999). Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther 6: 643-650.
6. Duncan C, Biro PA, Choudary PV, Elder JT, Wang RR, Forget BG, de Riel JK, Weissman SM (1979) RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes. Proc Natl Acad Sci U S A 76: 5095-5099.
7. El-Aneed A (2004) An overview of current delivery systems in cancer gene therapy. J Control Release 94: 1-14. (Pubitemid 37542373)
8. Germershaus O, Mao S, Sitterberg J, Bakowsky U, Kissel T (2007) Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure- activity relationships in vitro. J Control Release 125: 145-154. (Pubitemid 350299611)
9. Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Fischer A, Davies EG, Kuis W, Leiva L, Cavazzana-Calvo M (2002) Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 346: 1185-1193.
10. Jiang HL, Kim YK, Arote R, Nah JW, Cho MH, Choi YJ, Akaike T, Cho CS (2007) Chitosan-graft-polyethylenimine as a gene carrier. J Control Release 117: 273-280.
11. Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, Glader B, Chew AJ, Tai SJ, Herzog RW, Arruda V, Johnson F, Scallan C, Skarsgard E, Flake AW, High KA (2000) Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet 24: 257-261. (Pubitemid 30132193)
12. Kichler A, Pages JC, Leborgne C, Druillennec S, Lenoir C, Coulaud D, Delain E, Le Cam E, Roques BP, Danos O (2000). Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R. J Virol 74: 5424-5431. (Pubitemid 30346573)
13. Lungwitz U, Breunig M, Blunk T, Göpferich A (2005) Polyethylenimine-based non-viral gene delivery systems. Eur J Pharm Biopharm 60: 247-266. (Pubitemid 40804565)
14. Moret I, Esteban Peris J, Guillem VM, Benet M, Revert F, Dasí F, Crespo A, Aliño SF (2001) Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum. J Control Release 76: 169-181. (Pubitemid 32786894)
15. Oh YK, Suh D, Kim JM, Choi HG, Shin K, Ko JJ (2002) Polyethylenimine- mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA. Gene Ther 9: 1627-1632.
16. Suh J, Paik HJ, Hwang B (1994) Ionization of poly(ethylenimine) and poly(allylamine) at various pH's, Bioorg. Chem 22: 318-327.
17. van der Aa MA, Huth US, Häfele SY, Schubert R, Oosting RS, Mastrobattista E, Hennink WE, Peschka-Süss R, Koning GA, Crommelin DJ (2007) Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells. Pharm Res 24: 1590-1598.
18. Vold IM, Christensen BE (2005) Periodate oxidation of chitosans with different chemical compositions Carbohydr Res 340: 679-684.
19. von Harpe A, Petersen H, Li Y, Kissel T (2000) Characterization of commercially available and synthesized polyethylenimines for gene delivery. J Control Release 69: 309-322.
20. Wong K, Sun G, Zhang X, Dai H, Liu Y, He C, Leong KW (2006) PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjug Chem 17: 152-158.
21. Wong SY, Pelet JM, Putnam D (2007) Polymer systems for gene delivery - Past, present, and future. Prog Polym Sci 32: 799-837.
22. Xiong MP, Laird Forrest M, Ton G, Zhao A, Davies NM, Kwon GS (2007) Poly (aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery. Biomaterials 28: 4889-4900.