Simultaneous determination of aripiprazole and its active metabolite, dehydroaripiprazole, in plasma by capillary electrophoresis combining on-column field-amplified sample injection and application in schizophrenia

Electrophoresis

Volumn 31, Issue 16, 2010, Pages 2778-2786

  Hwang, Pei Lin ^a   Wei, Shao Yun ^a   Yeh, Hsin Hua ^a   Ko, Ju Yun ^b   Chang, Cheng Chen ^c   Chen, Su Hwei ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

Author keywords

Aripiprazole and dehydroaripiprazole in plasma; Field amplified sample injection; Liquid liquid extraction; Schizophrenia

Indexed keywords

BIOMOLECULES; DISEASES; METABOLITES; METHANOL; SOLVENT EXTRACTION;

ACTIVE METABOLITES; ARIPIPRAZOLE; ARIPIPRAZOLE AND DEHYDROARIPIPRAZOLE IN PLASMA; FIELD-AMPLIFIED SAMPLE INJECTION; LIQUID-LIQUID EXTRACTION; PERFORMANCE; PHOSPHATE BUFFERS; SAMPLE APPLICATIONS; SCHIZOPHRENIA; SIMULTANEOUS DETERMINATIONS;

CAPILLARY ELECTROPHORESIS;

AMLODIPINE; ARIPIPRAZOLE; DEHYDROARIPIPRAZOLE; DRUG METABOLITE; PHOSPHATE BUFFERED SALINE; UNCLASSIFIED DRUG;

ACIDITY; ADULT; ANALYTIC METHOD; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTRIC ACTIVITY; ELECTROKINESIA; FEMALE; FIELD AMPLIFIED SAMPLE INJECTION; HUMAN; KINETICS; LINEAR SYSTEM; LIQUID LIQUID EXTRACTION; MALE; PLASMA; SCHIZOPHRENIA; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; STEADY STATE; VOLUNTEER;

EID: 77955885380     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000237     Document Type: Article

References (22)

1. Harrison, T. S., Caroline, M. P., Drugs 2004, 64, 1715-1736.
2. Davies, M. A., Sheffler, D. J., Roth, B. L., CNS Drug Rev. 2004, 10, 317-336.
3. Jordan, S., Koprivica, V., Chen, R., Tottori, K., Kikuchi, T., Altar, C. A., Eur. J. Pharmacol. 2002, 441, 137-140.
4. Wisniewski, S. R., Chen, C. C., Kim, E., Kan, H. J., Pharmacoepidemiol. Drug Saf. 2009, 18, 965-972.
5. Schieber, F. C., Boulton, D. W., Balch, A. H., Croop, R., Mallikaarjun, S., Benson, J., Carlson, B. X., Hum. Psychopharmacol. Clin. Exp. 2009, 24, 145-152.
6. Huang, H. C., Liu, C. H., Lan, T. H., Hu, T. M., Chiu, H. J., Wu, Y. C., Tseng, Y. L., J. Chromatogr. B 2007, 856, 57-61.
7. Kubo, M., Mizooku, Y., Hirao, Y., Osumi, T., J. Chromatogr. B 2005, 822, 294-299.
8. Song, M., Xu, X., Hang, T., Wen, A., Yang, L., Anal. Biochem. 2009, 385, 270-277.
9. Kirchherr, H., Kuehn-Velten, W. N., J. Chromatogr. B 2006, 843, 100-113.
10. Molden, E., Lunde, H., Lunder, N., Refsum, H., Ther. Drug Monit. 2006, 28, 744-749.
11. Lin, S. N., Lamm, L., Newton, T. F., Reid, M. S., Moody, D. E., Foltz, R. L., J. Anal. Toxicol. 2009, 33, 237-242.
12. Zuo, X. C., Wang, F., Xu, P., Zhu, R. H., Li, H. D., Chromatographia 2006, 64, 387-391.
13. Musenga, A., Saracino, M. A., Spinelli, D., Rizzato, E., Boncompagni, G., Kenndler, E., Raggi, M. A., Anal. Chim. Acta 2008, 612, 204-211.
14. Lancelin, F., Djebrani, K., Tabaouti, K., Kraoul, L., Brovedani, S., Paubel, P., Piketty, M. L., J. Chromatogr. B 2008, 867, 15-19.
15. Waldschmitt, C., Pfuhlmann, B., Hiemke, C., Chromatographia 2009, 69, 821-827.
16. Chien, R. L., Burgi, D. S., J. Chromatogr. 1991, 559, 141-152.
17. Christofer, E. W., Edgar, A. A., Electrophoresis 2006, 27, 4523-4531.
18. Sentellas, S., Moyano, E., Puignou, L., Galceran, M. T., Electrophoresis 2003, 24, 3075-3082.
19. Song, J. Z., Chen, J., Tian, S. J., Sun, Z. P., J. Pharm. Biomed. Anal. 1999, 21, 569-576.
20. Quirino, J. P., Terabe, S., J. Chromatogr. A 2000, 902, 119-135.
21. Kuhn, R., Hoffstetter-Kuhn, S., Capillary Electrophoresis: Principles and Practice, Springer, Berlin, Germany 1993, pp. 99-101.
22. Chouinard, G., Jones, B. D., Am. J. Psychiatry 1980, 137, 16-21.