Randomized controlled phase II comparison study of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil versus CCRT with cisplatin, 5-fluorouracil, methotrexate and leucovorin in patients with locally advanced squamous cell carcinoma of the head and neck

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 4, 2010, Pages 729-736

  Tsukuda, Mamoru ^a   Ishitoya, Junichi ^b   Matsuda, Hideki ^a   Horiuchi, Choichi ^a   Taguchi, Takahide ^a   Takahashi, Masahiro ^a   Nishimura, Goshi ^a   Kawakami, Mariko ^a   Watanabe, Makiko ^a   Niho, Tatsuo ^a   Kawano, Toshiro ^b   Ikeda, Yoichi ^b   Sakuma, Yasunori ^b   Shiono, Osamu ^b   Komatsu, Masanori ^b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

Author keywords

5 fluorouracil; Cisplatin; Concurrent chemoradiotherapy; Docetaxel; Squamous cell carcinoma of the head and neck (SCCHN)

Indexed keywords

CISPLATIN; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; METHOTREXATE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; TAXOID; TPF PROTOCOL; VITAMIN B COMPLEX;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLEEDING; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DELIRIUM; DIARRHEA; DIGESTIVE SYSTEM ULCER; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPHAGIA; FEMALE; FEVER; GLOMERULUS FILTRATION RATE; HEAD AND NECK CARCINOMA; HEAD AND NECK SURGERY; HUMAN; HYPOALBUMINEMIA; HYPOPHARYNX CARCINOMA; ILEUS; INFECTION; KIDNEY DISEASE; LARYNX CARCINOMA; LEUKOPENIA; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MAXILLA SINUS CARCINOMA; MOTOR NEUROPATHY; MOUTH CARCINOMA; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PAIN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DERMATITIS; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TREATMENT OUTCOME; BIOASSAY; HEAD AND NECK TUMOR; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; SURVIVAL; TUMOR RECURRENCE; ADVANCED CANCER; CANCER SURVIVAL; CHEMORADIOTHERAPY; LIVER TOXICITY; MOTOR DYSFUNCTION; NEPHROTOXICITY; NEUROPATHY; TREATMENT RESPONSE;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; ENDPOINT DETERMINATION; FEMALE; FLUOROURACIL; HEAD AND NECK NEOPLASMS; HUMANS; KAPLAN-MEIERS ESTIMATE; LEUCOVORIN; MALE; METHOTREXATE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SURVIVAL ANALYSIS; TAXOIDS; VITAMIN B COMPLEX;

EID: 77955884315     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1217-0     Document Type: Article

References (23)

1. Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics, 1999. CA Cancer J Clin 49:8-31
2. Clayman GL, Lipman SM, Laramore GE, Ki Hong W (2000) Head and neck neoplasms. In: Holland JF, Kufe DW, Pollock RE et al (eds) Holland-Frei cancer medicine, 5th edn. BC Decker, Philadelphia, pp 1173-1220
3. Pignon JP, Bourhis J, Domenge C, Designé L, MACH-NC Collaborative Group (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Meta-analysis of chemotherapy on head and neck cancer. Lancet 355:949-955
4. Monnerat C, Faivre S, Temam S, Bourhis J, Raymond E (2002) End points for new agents in induction chemotherapy for locally advanced head and neck cancers. Ann Oncol 13:995-1006
5. Bourhis J, Le Maître A, Baujat B, Audry H, Pignon JP, Meta-Analysis of Chemotherapy in Head, Neck Cancer Collaborative Group, Meta-Analysis of Radiotherapy in Carcinoma of Head, Neck Collaborative Group, Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma Collaborative Group (2007) Individual patients' data meta-analyses in head and neck cancer. Curr Opin Oncol 19:188-194 (Pubitemid 46597476)
6. Pignon JP, Syz N, Posner M, Olivares R, Le Lann L, Yver A, Dunant A, Lewin F, Dalley DN, Paccagnella A, Taylor SG, Domenge C, Bourhis J, Mazumdar M (2004) Adjusting for patient selection suggests the addition of docetaxel to 5-fluorouracil-cisplatin induction chemotherapy may offer survical benefit in squamous cell cancer of the head and neck. Anticancer Drugs 15 (4):331-340
7. Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL, EORTC 24971/TAX 323 Study Group (2007) Cisplatin, fluorouracil, and decetaxel in unresectable head and neck cancer. N Engl J Med 357 (17):1695-1704
8. Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M, Cmelak A, Markoe AM, Read PW, Steinbrenner L, Colevas AD, Norris CM Jr, Haddad RI, TAX 324 Study Group (2007) Cisplatin and fluorouracil alone or with decetaxel in head and neck cancer. N Engl J Med 357 (17):1705-1715
9. Seiwert TY, Cohen EEW (2005) State of the art management of locally advanced head and neck cancer. Br J Cancer 92:1341-1348
10. Salama JK, Seiwert TY, Vokes EE (2007) Chemoradiotherapy for locally advanced head and neck cancer. J Clin Oncol 25 (26):4118-4126
11. Tsukuda M, Mikami Y, Tanigaki Y, Katori H, Horiuchi C, Ikeda Y, Taguchi T, Ono M, Yoshida T, Sakuma Y, Aikoh K (2004) Phase 1 trial of combined chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) for patients with locally locally advanced squamous cell carcinoma of the head and neck. Int J Clin Oncol 9:161-166 (Pubitemid 38899748)
12. Katori H, Tsukuda M, Mochimatu I, Ishitoya J, Kawai S, Mikami Y, Matsuda H, Tanigaki Y, Horiuchi C, Ikeda Y, Taguchi T, Ono M, Yoshida T, Hirose S, Sakuma Y, Yamamoto K (2004) Phase 1 trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Br J Cancer 90:348-352 (Pubitemid 38250627)
13. Katori H, Tsukuda M, Watai K (2007) Comparison of hyperfractionation and conventional fractionation radiotherapy with concurrent docetaxel, cisplatin and 5-fluorouracil (TPF) chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Cancer Chemother Pharmacol 60 (3):399-406
14. Katori H, Tsukuda M (2005) Comparison of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by radiation vs concurrent chemoradiotherapy with TPF in patients with locally advanced squamous cell carcinoma of the head and neck. Clin Oncol (R Coll Radiol) 17 (3):148-152 (Pubitemid 40468479)
15. Taguchi T, Tsukuda M, Katori H (2006) Concurrent chemoradiotherapy with cisplatin, 5-fluorouracil, methotrexate, and leucovorin in patients with advanced resectable squamous cell carcinoma of the larynx and hypopharynx. Acta Otolaryngol 126:408-413
16. Katori H, Tsukuda M, Taguchi T (2007) Analysis of efficacy and toxicity of chemotherapy with cisplatin, 5-fluorouracil, methotrexate and leucovorin (PFML) and radiotherapy in the treatment of locally advanced squamous cell carcinoma of the head and neck. Cancer Chemother Pharmacol 59 (6):789-794 (Pubitemid 46440602)
17. Taguchi T, Tsukuda M, Mikami Y, Matsuda H, Tanigaki Y, Horiuchi C, Nishimura G, Nagao JI (2009) Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy. Auris Nasus Larynx 36 (2):199-204
18. World Health Organization (1979) WHO Handbook for reporting results of cancer treatment. WHO offset publication No. 48. World Health Organization, Geneva
19. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349 (22):2091-2098
20. Cohen EE, Lingen MW, Vokes EE (2004) The expanding role of systemic therapy in head and neck cancer. J Clin Oncol 22:1743-1752
21. Urba SG, Moon J, Giri PG, Adelstein DJ, Hanna E, Yoo GH, Leblanc M, Ensley JF, Schuller DE (2005) Organ preservation for advanced respectable cancer of the base of tongue and hypopharynx: a southwest oncology group trial. J Clin Oncol 23 (1):88-95
22. Adelstein DJ, Saxton JP, Rybicki LA, Esclamado RM, Wood BG, Strome M, Lavertu P, Lorenz RR, Carroll MA (2006) Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer. J Clin Oncol 24 (7):1064-1071
23. Bensadoun RJ, Bénézery K, Dassonville O, Magné N, Poissonnet G, Ramaïoli A, Lemanski C, Bourdin S, Tortochaux J, Peyrade F, Marcy PY, Chamorey E, Vallicioni J, Seng H, Alzieu C, Géry B, Chauvel P, Schneider M, Santini J, Demard F, Calais G (2006) French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 yaers (FNCLCC-GHORTEC). Int J Radiat Oncol Biol Physi 64 (4):983-994