Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats

Toxicological Sciences

Volumn 117, Issue 1, 2010, Pages 36-44

  Martin, Lori ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P450; Dose response; Liver; PCB congeners; Thyroid hormones

Indexed keywords

2,2',4,4',5 PENTACHLOROBIPHENYL; 2,3',4,4',5 PENTACHLOROBIPHENYL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3'4,4',5 PENTACHLOROBIPHENYL; AROCLOR 1242; CORN OIL; CYTOCHROME P450 1A; CYTOCHROME P450 2B; ENZYME; ETHOXYRESORUFIN DEETHYLASE; LIOTHYRONINE; PENTOXYRESORUFIN O DEETHYLASE; POLYCHLORINATED BIPHENYL; THYROID HORMONE; THYROTROPIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONCENTRATION RESPONSE; CONTRAST; CORN; FEEDING; HORMONE DETERMINATION; LIOTHYRONINE BLOOD LEVEL; LIVER; MALE; NONHUMAN; RADIOIMMUNOASSAY; RAT; SPRAGUE DAWLEY RAT; THYROID HORMONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; THYROID HORMONES;

RATTUS; ZEA MAYS;

EID: 77955880865     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq187     Document Type: Article

References (42)

1. Alvarez-Lloret, P., Lind, P. M., Nyberg, I., Orberg, J., and Rodríguez-Navarro, A. B. (2009). Effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats. Toxicol. Lett. 187, 63-68.
2. Bager, Y., Hemming, H., Flodstrom, S., Ahlborg, U. G., and Warngard, L. (1995). Interaction of 3,4,5,3',4'-pentachlorobiphenyl and 2,4,5,2',4',5'-hexachlorobiphenyl in promotion of altered hepatic foci in rats. Pharmacol. Toxicol. 77, 149-154.
3. Barter, R. A., and Klaassen, C. D. (1994). Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. Toxicol. Appl. Pharmacol. 128, 9-17.
4. Beetstra, J. B., van Engelen, J. G., Karels, P., van der Hoek, H. J., de Jong, M., Docter, R., Krenning, E. P., Hennemann, G., Brouwer, A., and Visser, T. J. (1991). Thyroxine and 3,3',5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases. Endocrinology 128, 741-746.
5. Braathen, M., Derocher, A. E., Wiig, Ø., Sørmo, E. G., Lie, E., Skaare, J. U., and Jenssen, B. M. (2004). Relationships between PCBs and thyroid hormones and retinol in female and male polar bears. Environ. Health Perspect. 112, 826-833.
6. Burgin, D. E., Diliberto, J. J., Derr-Yellin, E. C., Kannan, N., Kodavanti, P. R., and Birnbaum, L. S. (2001). Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. Environ. Health Perspect. 109, 1163-1168.
7. Chu, I., Villeneuve, D. C., Yagminas, A., Lecavalier, P., Hakansson, H., Ahlborg, U. G., Valli, V. E., Kennedy, S. W., Bergman, A., Seegal, R. F., et al. (1995). Toxicity of PCB 77 (3,3',4,4'-tetrachlorobiphenyl) and PCB 118 (2,3',4,4'5-pentachlorobiphenyl) in the rat following subchronic dietary exposure. Fundam. Appl. Toxicol. 26, 282-292.
8. 125I-thyroxine and fine structural alterations in the thyroid glands of Gunn rats fed polychlorinated biphenyls (PCB). Lab. Invest. 43, 158-164.
9. Connor, K., Safe, S., Jefcoate, C. R., and Larsen, M. (1995). Structuredependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats. Biochem. Pharmacol. 50, 1913-1920.
10. Cooke, P. S., Zhao, Y. D., and Hansen, L. G. (1996). Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. Toxicol. Appl. Pharmacol. 136, 112-117.
11. Craft, E. S., DeVito, M. J., and Crofton, K. M. (2002). Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbitallike polychlorinated biphenyl congeners. Toxicol. Sci. 68, 372-380.
12. De Voogt, P., and Brinkman, A. T. (1989). Production properties and usage of polychlorinated biphenyls. In Halogenated Biphenyls, Terphenyls, Naphthalenes and Dibenzodioxins and Related Products (R. D. Kimbrough and A. A. Jensen, Eds.). Elsevier, New York.
13. Desaulniers, D., Leingartner, K., Wade, M., Fintelman, E., Yagminas, A., and Foster, W. G. (1999). Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats. Toxicol. Sci. 47, 158-169.
14. Fischer, L. J., Seegal, R. F., Ganey, P. E., Pessah, I. N., and Kodavanti, P. R. (1998). Symposium overview: toxicity of non-coplanar PCBs. Toxicol. Sci. 41, 49-61.
15. Fisher, J. W., Campbell, J., Muralidhara, S., Bruckner, J. V., Ferguson, D., Mumtaz, M., Harmon, B., Hedge, J. M., Crofton, K. M., et al. (2006). Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicol. Sci. 90, 87-95.
16. Frame, G. M., Wagner, R. M., Carnahan, J. C., Brown, J. F., Jr., May, R. J., Smullen, L. A., and Bedard, D. L. (1996). Comprehensive, quantitative, congener specific analyses of eight aroclors and complete PCB congener assignments on DB-1 capillary GC columns. Chemosphere 33, 603-623.
17. Gutleb, A. C., Cenijn, P., Velzen, M., Lie, E., Ropstad, E., Skaare, J. U., Malmberg, T., Bergman, A., Gabrielsen, G. W., and Legler, J. (2010). In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus). Environ. Sci. Technol. 44, 3149-3154.
18. Harris, M., Zacharewski, T., and Safe, S. (1993). Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats-assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundam. Appl. Toxicol. 20, 456-463.
19. Hood, A., Hashmi, R., and Klaassen, C. D. (1999). Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol. Appl. Pharmacol. 160, 163-170.
20. Hood, A., and Klaassen, C. D. (2000). Differential effects of microsomal enzyme inducers on in vitro thyroxine (T4) and triiodothyronine (T3) glucuronidation. Toxicol. Sci. 55, 78-84.
21. Khan, M. A., Lichtensteiger, C. A., Faroon, O., Mumtaz, M., Schaeffer, D. J., and Hansen, L. G. (2002). The hypothalamo-pituitary-thyroid (HPT) axis: a target of nonpersistent ortho-substituted PCB congeners. Toxicol. Sci. 65, 52-61.
22. Klaassen, C. D., and Hood, A. M. (2001). Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism. Toxicol. Pathol. 29, 34-40.
23. Kohn, M. C. (2000). Effects of TCDD on thyroid hormone homeostasis in the rat. Drug Chem. Toxicol. 23, 259-277.
24. Kohrle, J. (2000). The deiodinase family: selenoenzymes regulating thyroid hormone availability and action. Cell. Mol. Life Sci. 57, 1853-1863.
25. Li, M. H., and Hansen, L. G. (1997). Consideration of enzyme and endocrine interactions in the risk assessment of PCBs. Rev. Toxicol. 1, 71-156.
26. Liu, J., Liu, Y., Barter, R. A., and Klaassen, C. D. (1995). Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: A doseresponse study. J. Pharmacol. Exp. Ther. 273, 977-985.
27. Liu, Y., Apak, T. I., Lehmler, H. J., Robertson, L. W., and Duffel, M. W. (2006). Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem. Res. Toxicol. 19, 1420-1425.
28. Matthews, H. B., and Dedrick, R. L. (1984). Pharmacokinetics of PCBs. Annu. Rev. Pharmacol. Toxicol. 24, 85-103.
29. Mayes, B. A., McConnell, E. E., Neal, B. H., Brunner, M. J., Hamilton, S. B., Sullivan, T. M., Peters, A. C., Ryan, M. J., Toft, J. D., Singer, A. W., et al. (1998). Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol. Sci. 41, 62-76.
30. National Toxicology Program. (2006). NTP Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CAS No. 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 526, 1-180.
31. Ness, D. K., Schantz, S. L., Moshtaghian, J., and Hansen, L. G. (1993). Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol. Lett. 68, 311-323.
32. Safe, S. (1984). Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Crit. Rev. Toxicol. 13, 319-395.
33. Safe, S., Bandiera, S., Sawyer, T., Robertson, L., Safe, L., Parkinson, A., Thomas, P. E., Ryan, D. E., Reik, L. M., Levin, W., et al. (1985). PCBs: structure-function relationships and mechanism of action. Environ. Health Perspect. 60, 47-56.
34. Safe, S. H. (1994). Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit. Rev. Toxicol. 24, 87-149.
35. Schuur, A. G., Boekhorst, F. M., Brouwer, A., and Visser, T. J. (1997). Extrathyroidal effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover in male Sprague-Dawley rats. Endocrinology 138, 3727-3734.
36. Seo, B. W., Li, M. H., Hansen, L. G., Moore, R. W., Peterson, R. E., and Schantz, S. L. (1995). Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlor-odibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. Toxicol. Lett. 78, 253-262.
37. van der Plas, S. A., Lutkeschipholt, I., Spenkelink, B., and Brouwer, A. (2001). Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female Sprague-Dawley rats. Toxicol. Sci. 59, 92-100.
38. Vansell, N. R., and Klaassen, C. D. (2002). Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T3) and its metabolites. Toxicol. Sci. 65, 184-191.
39. Vansell, N. R., Muppidi, J. R., Habeebu, S. M., and Klaassen, C. D. (2004). Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicol. Sci. 81, 50-59.
40. Viluksela, M., Raasmaja, A., Lebofsky, M., Stahl, B. U., and Rozman, K. K. (2004). Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5'-deiodinases I and II in rats. Toxicol. Lett. 147, 133-142.
41. Visser, T. J., Kaptein, E., Gijzel, A. L., de Herder, W. W., Ebner, T., and Burchell, B. (1993). Glucuronidation of thyroid hormone by human bilirubin and phenol UDP-glucuronyltransferase isoenzymes. FEBS Lett. 324, 358-360.
42. Wang, L. Q., and James, M. O. (2006). Inhibition of sulfotransferases by xenobiotics. Curr. Drug Metab. 7, 83-104.